RCP9

CRCP
Identifiers
Aliases	CRCP , CGRP-RCP, CGRPRCP, RCP, RCP9, CGRP receptor component, RPC9, POLR3I, POLR3J, C17
External IDs	OMIM: 606121 MGI: 1100818 HomoloGene: 40587 GeneCards: CRCP
Gene location (Human)
Chr.	Chromosome 7 (human)
End	66,154,568 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	130,089,630 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; ganglionic eminence; ; islet of Langerhans; ; right lobe of liver; ; monocyte; ; oocyte; ; rectum; ; amniotic fluid; ; stromal cell of endometrium; ; prefrontal cortex;
	Top expressed in
	spermatocyte; ; barrel cortex; ; motor neuron; ; Paneth cell; ; mirror; ; trigeminal ganglion; ; seminiferous tubule; ; morula; ; fossa; ; primitive streak;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding ; RNA polymerase III activity ; DNA-directed 5'-3' RNA polymerase activity ; protein binding ; catalytic activity ; calcitonin gene-related peptide receptor activity ;
Cellular component	cytosol ; membrane ; plasma membrane ; nucleoplasm ; acrosomal vesicle ; DNA polymerase III complex ; nucleus ; RNA polymerase III complex ; nuclear DNA-directed RNA polymerase complex ; RNA polymerase complex ;
Biological process	immune system process ; cell metabolism ; defense response to virus ; neuropeptide signaling pathway ; transcription by RNA polymerase III ; innate immune response ; DNA-templated transcription, initiation ; transcription initiation from RNA polymerase III promoter ; positive regulation of type I interferon production ;
	Sources:Amigo / QuickGO
Orthologs
	27297
	12909
	ENSG00000241258
	ENSMUSG00000025532
	O75575
	O35427
	NM_001040647 ; NM_001040648 ; NM_001142414 ; NM_014478
	NM_007761
	NP_001035737 ; NP_001035738 ; NP_001135886 ; NP_055293
	NP_031787
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 14, 2022

DNA-directed RNA polymerase III subunit RPC9 is an enzyme that in humans is encoded by the CRCP gene.^[5]^[6]^[7]^[8]

This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[8]

Related Research Articles

Calcitonin gene-related peptide (CGRP) is a member of the calcitonin family of peptides consisting of calcitonin, amylin, adrenomedullin, adrenomedullin 2 (intermedin) and calcitonin‑receptor‑stimulating peptide. Calcitonin is mainly produced by thyroid C cells whilst CGRP is secreted and stored in the nervous system. This peptide, in humans, exists in two forms: CGRP alpha, and CGRP beta. α-CGRP is a 37-amino acid neuropeptide and is formed by alternative splicing of the calcitonin/CGRP gene located on chromosome 11. β-CGRP is less studied. In humans, β-CGRP differs from α-CGRP by three amino acids and is encoded in a separate, nearby gene. The CGRP family includes calcitonin (CT), adrenomedullin (AM), and amylin (AMY).

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Receptor activity modifying protein 1 is a protein that in humans is encoded by the RAMP1 gene.

Receptor activity modifying protein 2, also known as RAMP2, is a protein which in humans is encoded by the RAMP2 gene.

Receptor activity modifying protein 3, also known as RAMP3, is a human gene.

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The prolactin-releasing peptide receptor (PrRPR) also known as G-protein coupled receptor 10 (GPR10) is a protein that in humans is encoded by the PRLHR gene.

<span class="mw-page-title-main">CALCRL</span> Mammalian protein found in Homo sapiens

Calcitonin receptor-like (CALCRL), also known as the calcitonin receptor-like receptor (CRLR), is a human protein; it is a receptor for calcitonin gene-related peptide.

Neuropeptide FF receptor 2, also known as NPFF2 is a human protein encoded by the NPFFR2 gene.

Cyclin-C is a protein that in humans is encoded by the CCNC gene.

Elongin A is a protein that in humans is encoded by the ELOA gene.

Mediator of RNA polymerase II transcription subunit 17 is an enzyme that in humans is encoded by the MED17 gene.

SET domain containing 2 is an enzyme that in humans is encoded by the SETD2 gene.

Preprotachykinin-1,, is a precursor protein that in humans is encoded by the TAC1 gene.

AKT-interacting protein is a protein that in humans is encoded by the AKTIP gene.

ADM2 is a protein that in humans is encoded by the ADM2 gene.

DNA-directed RNA polymerase III subunit RPC5 is an enzyme that in humans is encoded by the POLR3E gene.

Probable G-protein coupled receptor 61 is a protein that in humans is encoded by the GPR61 gene.

GPR182 is a human gene which is an orphan G-protein coupled receptor.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000241258 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025532 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Luebke AE, Dahl GP, Roos BA, Dickerson IM (Jun 1996). "Identification of a protein that confers calcitonin gene-related peptide responsiveness to oocytes by using a cystic fibrosis transmembrane conductance regulator assay". Proc Natl Acad Sci U S A. 93 (8): 3455–60. doi: 10.1073/pnas.93.8.3455 . PMC 39630 . PMID 8622957.
↑ Balkan W, Oates EL, Howard GA, Roos BA (Mar 1999). "Testes exhibit elevated expression of calcitonin gene-related peptide receptor component protein". Endocrinology. 140 (3): 1459–69. doi: 10.1210/endo.140.3.6541 . PMID 10067875.
↑ Siaut M, Zaros C, Levivier E, Ferri ML, Court M, Werner M, Callebaut I, Thuriaux P, Sentenac A, Conesa C (Dec 2002). "An Rpb4/Rpb7-Like Complex in Yeast RNA Polymerase III Contains the Orthologue of Mammalian CGRP-RCP". Mol Cell Biol. 23 (1): 195–205. doi:10.1128/MCB.23.1.195-205.2003. PMC 140662 . PMID 12482973.
1 2 "Entrez Gene: RCP9 calcitonin gene-related peptide-receptor component protein".

Yallampalli C, Chauhan M, Thota CS, et al. (2003). "Calcitonin gene-related peptide in pregnancy and its emerging receptor heterogeneity". Trends Endocrinol. Metab. 13 (6): 263–9. doi:10.1016/s1043-2760(02)00563-5. PMID 12128288. S2CID 28476322.
Evans BN, Rosenblatt MI, Mnayer LO, et al. (2000). "CGRP-RCP, a novel protein required for signal transduction at calcitonin gene-related peptide and adrenomedullin receptors". J. Biol. Chem. 275 (40): 31438–43. doi: 10.1074/jbc.M005604200 . PMID 10903324.
Prado MA, Evans-Bain B, Oliver KR, Dickerson IM (2002). "The role of the CGRP-receptor component protein (RCP) in adrenomedullin receptor signal transduction". Peptides. 22 (11): 1773–81. doi:10.1016/S0196-9781(01)00517-4. PMID 11754963. S2CID 37139980.
Moreno MJ, Terrón JA, Stanimirovic DB, et al. (2002). "Characterization of calcitonin gene-related peptide (CGRP) receptors and their receptor-activity-modifying proteins (RAMPs) in human brain microvascular and astroglial cells in culture". Neuropharmacology. 42 (2): 270–80. doi:10.1016/S0028-3908(01)00176-9. PMID 11804624. S2CID 45479910.
Harzenetter MD, Keller U, Beer S, et al. (2002). "Regulation and function of the CGRP receptor complex in human granulopoiesis". Exp. Hematol. 30 (4): 306–12. doi:10.1016/S0301-472X(02)00772-5. PMID 11937264.
Hu P, Wu S, Sun Y, et al. (2002). "Characterization of Human RNA Polymerase III Identifies Orthologues for Saccharomyces cerevisiae RNA Polymerase III Subunits" (PDF). Mol. Cell. Biol. 22 (22): 8044–55. doi:10.1128/MCB.22.22.8044-8055.2002. PMC 134740 . PMID 12391170.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Hasbak P, Saetrum Opgaard O, Eskesen K, et al. (2003). "Investigation of CGRP receptors and peptide pharmacology in human coronary arteries. Characterization with a nonpeptide antagonist". J. Pharmacol. Exp. Ther. 304 (1): 326–33. doi:10.1124/jpet.102.037754. PMID 12490608. S2CID 14045615.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
Zuccarello D, Morini E, Douzgou S, et al. (2005). "Preliminary data suggest that mutations in the CgRP pathway are not involved in human sporadic cryptorchidism". J. Endocrinol. Invest. 27 (8): 760–4. doi:10.1007/bf03347519. PMID 15636430. S2CID 19253890.
Krämer HH, Schmidt K, Leis S, et al. (2006). "Angiotensin converting enzyme has an inhibitory role in CGRP metabolism in human skin". Peptides. 27 (4): 917–20. doi:10.1016/j.peptides.2005.08.007. PMID 16406141. S2CID 24455456.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000241258 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025532 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8622957-5] Luebke AE, Dahl GP, Roos BA, Dickerson IM (Jun 1996). "Identification of a protein that confers calcitonin gene-related peptide responsiveness to oocytes by using a cystic fibrosis transmembrane conductance regulator assay". Proc Natl Acad Sci U S A. 93 (8): 3455–60. doi: 10.1073/pnas.93.8.3455 . PMC 39630 . PMID 8622957.

[pmid10067875-6] Balkan W, Oates EL, Howard GA, Roos BA (Mar 1999). "Testes exhibit elevated expression of calcitonin gene-related peptide receptor component protein". Endocrinology. 140 (3): 1459–69. doi: 10.1210/endo.140.3.6541 . PMID 10067875.

[pmid12482973-7] Siaut M, Zaros C, Levivier E, Ferri ML, Court M, Werner M, Callebaut I, Thuriaux P, Sentenac A, Conesa C (Dec 2002). "An Rpb4/Rpb7-Like Complex in Yeast RNA Polymerase III Contains the Orthologue of Mammalian CGRP-RCP". Mol Cell Biol. 23 (1): 195–205. doi:10.1128/MCB.23.1.195-205.2003. PMC 140662 . PMID 12482973.

[entrez-8] 1 2 "Entrez Gene: RCP9 calcitonin gene-related peptide-receptor component protein".

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RCP9

Related Research Articles

References

Further reading