RCP9

CRCP
Identifiers
Aliases	CRCP , CGRP-RCP, CGRPRCP, RCP, RCP9, CGRP receptor component, RPC9, POLR3I, POLR3J, C17
External IDs	OMIM: 606121; MGI: 1100818; HomoloGene: 40587; GeneCards: CRCP; OMA:CRCP - orthologs
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q11.21 Start 66,114,604 bp [1] End 66,154,568 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 G1.3 Start 130,058,131 bp [2] End 130,089,630 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon ganglionic eminence islet of Langerhans right lobe of liver monocyte oocyte rectum amniotic fluid stromal cell of endometrium prefrontal cortex Top expressed in dentate gyrus of hippocampal formation granule cell spermatocyte barrel cortex motor neuron Paneth cell endothelial cell of lymphatic vessel lens trigeminal ganglion seminiferous tubule morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding RNA polymerase III activity DNA-directed 5'-3' RNA polymerase activity protein binding catalytic activity calcitonin gene-related peptide receptor activity Cellular component cytosol membrane plasma membrane nucleoplasm acrosomal vesicle DNA polymerase III complex nucleus RNA polymerase III complex nuclear DNA-directed RNA polymerase complex RNA polymerase complex Biological process immune system process cell metabolism defense response to virus neuropeptide signaling pathway transcription by RNA polymerase III innate immune response DNA-templated transcription, initiation transcription initiation from RNA polymerase III promoter positive regulation of type I interferon production Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27297 12909 Ensembl ENSG00000241258 ENSMUSG00000025532 UniProt O75575 O35427 RefSeq (mRNA) NM_001040647 NM_001040648 NM_001142414 NM_014478 NM_007761 RefSeq (protein) NP_001035737 NP_001035738 NP_001135886 NP_055293 NP_031787 Location (UCSC) Chr 7: 66.11 – 66.15 Mb Chr 5: 130.06 – 130.09 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

DNA-directed RNA polymerase III subunit RPC9 is an enzyme that in humans is encoded by the CRCP gene. ^{[5] [6] [7] [8]}

This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000241258 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025532 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Luebke AE, Dahl GP, Roos BA, Dickerson IM (Jun 1996). "Identification of a protein that confers calcitonin gene-related peptide responsiveness to oocytes by using a cystic fibrosis transmembrane conductance regulator assay". Proc Natl Acad Sci U S A. 93 (8): 3455–60. Bibcode:1996PNAS...93.3455L. doi: 10.1073/pnas.93.8.3455 . PMC   39630 . PMID   8622957.
6. Balkan W, Oates EL, Howard GA, Roos BA (Mar 1999). "Testes exhibit elevated expression of calcitonin gene-related peptide receptor component protein". Endocrinology. 140 (3): 1459–69. doi: 10.1210/endo.140.3.6541 . PMID   10067875.
7. Siaut M, Zaros C, Levivier E, Ferri ML, Court M, Werner M, Callebaut I, Thuriaux P, Sentenac A, Conesa C (Dec 2002). "An Rpb4/Rpb7-Like Complex in Yeast RNA Polymerase III Contains the Orthologue of Mammalian CGRP-RCP". Mol Cell Biol. 23 (1): 195–205. doi:10.1128/MCB.23.1.195-205.2003. PMC   140662 . PMID   12482973.
8. "Entrez Gene: RCP9 calcitonin gene-related peptide-receptor component protein".

Further reading

• Yallampalli C, Chauhan M, Thota CS, et al. (2003). "Calcitonin gene-related peptide in pregnancy and its emerging receptor heterogeneity". Trends Endocrinol. Metab. 13 (6): 263–9. doi:10.1016/s1043-2760(02)00563-5. PMID   12128288. S2CID   28476322.
• Evans BN, Rosenblatt MI, Mnayer LO, et al. (2000). "CGRP-RCP, a novel protein required for signal transduction at calcitonin gene-related peptide and adrenomedullin receptors". J. Biol. Chem. 275 (40): 31438–43. doi: 10.1074/jbc.M005604200 . PMID   10903324.
• Prado MA, Evans-Bain B, Oliver KR, Dickerson IM (2002). "The role of the CGRP-receptor component protein (RCP) in adrenomedullin receptor signal transduction". Peptides. 22 (11): 1773–81. doi:10.1016/S0196-9781(01)00517-4. PMID   11754963. S2CID   37139980.
• Moreno MJ, Terrón JA, Stanimirovic DB, et al. (2002). "Characterization of calcitonin gene-related peptide (CGRP) receptors and their receptor-activity-modifying proteins (RAMPs) in human brain microvascular and astroglial cells in culture". Neuropharmacology. 42 (2): 270–80. doi:10.1016/S0028-3908(01)00176-9. PMID   11804624. S2CID   45479910.
• Harzenetter MD, Keller U, Beer S, et al. (2002). "Regulation and function of the CGRP receptor complex in human granulopoiesis". Exp. Hematol. 30 (4): 306–12. doi: 10.1016/S0301-472X(02)00772-5 . PMID   11937264.
• Hu P, Wu S, Sun Y, et al. (2002). "Characterization of Human RNA Polymerase III Identifies Orthologues for Saccharomyces cerevisiae RNA Polymerase III Subunits" (PDF). Mol. Cell. Biol. 22 (22): 8044–55. doi:10.1128/MCB.22.22.8044-8055.2002. PMC   134740 . PMID   12391170.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Hasbak P, Saetrum Opgaard O, Eskesen K, et al. (2003). "Investigation of CGRP receptors and peptide pharmacology in human coronary arteries. Characterization with a nonpeptide antagonist". J. Pharmacol. Exp. Ther. 304 (1): 326–33. doi:10.1124/jpet.102.037754. PMID   12490608. S2CID   14045615.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID   15592455. S2CID   7200157.
• Zuccarello D, Morini E, Douzgou S, et al. (2005). "Preliminary data suggest that mutations in the CgRP pathway are not involved in human sporadic cryptorchidism". J. Endocrinol. Invest. 27 (8): 760–4. doi:10.1007/bf03347519. PMID   15636430. S2CID   19253890.
• Krämer HH, Schmidt K, Leis S, et al. (2006). "Angiotensin converting enzyme has an inhibitory role in CGRP metabolism in human skin". Peptides. 27 (4): 917–20. doi:10.1016/j.peptides.2005.08.007. PMID   16406141. S2CID   24455456.