RDH14

RDH14
Identifiers
Aliases	RDH14 , PAN2, SDR7C4, retinol dehydrogenase 14 (all-trans/9-cis/11-cis), retinol dehydrogenase 14
External IDs	OMIM: 616796 MGI: 1920402 HomoloGene: 75139 GeneCards: RDH14
Gene location (Human)
Chr.	Chromosome 2 (human)
End	18,560,679 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	10,445,562 bp
RNA expression pattern
	Top expressed in
	left ventricle; ; islet of Langerhans; ; gastrocnemius muscle; ; skeletal muscle tissue; ; Achilles tendon; ; smooth muscle tissue; ; thoracic aorta; ; ascending aorta; ; right coronary artery; ; rectum;
	Top expressed in
	interventricular septum; ; sternocleidomastoid muscle; ; masseter muscle; ; digastric muscle; ; triceps brachii muscle; ; temporal muscle; ; intercostal muscle; ; extraocular muscle; ; vastus lateralis muscle; ; tibialis anterior muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	alcohol dehydrogenase (NADP+) activity ; oxidoreductase activity ; NADP-retinol dehydrogenase activity ; steroid dehydrogenase activity ;
Cellular component	lysosomal membrane ; endoplasmic reticulum ; mitochondrion ; nucleus ; endoplasmic reticulum membrane ; membrane ;
Biological process	retinol metabolic process ; osteoblast differentiation ;
	Sources:Amigo / QuickGO
Orthologs
	57665
	105014
	ENSG00000240857
	ENSMUSG00000020621
	Q9HBH5
	Q9ERI6
	NM_020905
	NM_023697
	NP_065956
	NP_076186
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated May 13, 2024

Retinol dehydrogenase 14 is an enzyme that in humans is encoded by the RDH14 gene.^[5]^[6]^[7]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000240857 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020621 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Haeseleer F, Jang GF, Imanishi Y, Driessen CA, Matsumura M, Nelson PS, et al. (Nov 2002). "Dual-substrate Specificity Short Chain Retinol Dehydrogenases from the Vertebrate Retina". J Biol Chem. 277 (47): 45537–46. doi: 10.1074/jbc.M208882200 . PMC 1435693 . PMID 12226107.
↑ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, et al. (Feb 2009). "The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative". Chem Biol Interact. 178 (1–3): 94–8. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC 2896744 . PMID 19027726.
↑ "Entrez Gene: RDH14 retinol dehydrogenase 14 (all-trans/9-cis/11-cis)".

Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948 . PMID 11076863.
Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732 . PMID 11256614.
Belyaeva OV, Kedishvili NY (2002). "Human pancreas protein 2 (PAN2) has a retinal reductase activity and is ubiquitously expressed in human tissues". FEBS Lett. 531 (3): 489–93. Bibcode:2002FEBSL.531..489B. doi: 10.1016/S0014-5793(02)03588-3 . PMID 12435598. S2CID 22343979.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697 . PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930 . PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, Del Val C, Arlt D, Hahne F, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501 . PMID 16381901.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000240857 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020621 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12226107-5] Haeseleer F, Jang GF, Imanishi Y, Driessen CA, Matsumura M, Nelson PS, et al. (Nov 2002). "Dual-substrate Specificity Short Chain Retinol Dehydrogenases from the Vertebrate Retina". J Biol Chem. 277 (47): 45537–46. doi: 10.1074/jbc.M208882200 . PMC 1435693 . PMID 12226107.

[pmid19027726-6] Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, et al. (Feb 2009). "The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative". Chem Biol Interact. 178 (1–3): 94–8. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC 2896744 . PMID 19027726.

[entrez-7] "Entrez Gene: RDH14 retinol dehydrogenase 14 (all-trans/9-cis/11-cis)".

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RDH14

Related Research Articles

References

Further reading