RDH14

RDH14
Identifiers
Aliases	RDH14 , PAN2, SDR7C4, retinol dehydrogenase 14 (all-trans/9-cis/11-cis), retinol dehydrogenase 14
External IDs	OMIM: 616796; MGI: 1920402; HomoloGene: 75139; GeneCards: RDH14; OMA:RDH14 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2p24.2 Start 18,554,723 bp [1] End 18,560,679 bp [1]
Gene location (Mouse) Chr. Chromosome 12 (mouse) [2] Band 12|12 A1.1 Start 10,440,772 bp [2] End 10,445,562 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left ventricle islet of Langerhans right auricle of heart gastrocnemius muscle skeletal muscle tissue Achilles tendon smooth muscle tissue muscle of thigh thoracic aorta ascending aorta Top expressed in interventricular septum sternocleidomastoid muscle masseter muscle digastric muscle triceps brachii muscle temporal muscle intercostal muscle epithelium of lens extraocular muscle vastus lateralis muscle More reference expression data BioGPS n/a
Gene ontology Molecular function alcohol dehydrogenase (NADP+) activity oxidoreductase activity NADP-retinol dehydrogenase activity steroid dehydrogenase activity Cellular component lysosomal membrane endoplasmic reticulum mitochondrion nucleus endoplasmic reticulum membrane membrane Biological process retinol metabolic process osteoblast differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57665 105014 Ensembl ENSG00000240857 ENSMUSG00000020621 UniProt Q9HBH5 Q9ERI6 RefSeq (mRNA) NM_020905 NM_023697 RefSeq (protein) NP_065956 NP_076186 Location (UCSC) Chr 2: 18.55 – 18.56 Mb Chr 12: 10.44 – 10.45 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Retinol dehydrogenase 14 is an enzyme that in humans is encoded by the RDH14 gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000240857 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020621 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Haeseleer F, Jang GF, Imanishi Y, Driessen CA, Matsumura M, Nelson PS, et al. (Nov 2002). "Dual-substrate Specificity Short Chain Retinol Dehydrogenases from the Vertebrate Retina". J Biol Chem. 277 (47): 45537–46. doi: 10.1074/jbc.M208882200 . PMC   1435693 . PMID   12226107.
6. Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, et al. (Feb 2009). "The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative". Chem Biol Interact. 178 (1–3): 94–8. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC   2896744 . PMID   19027726.
7. "Entrez Gene: RDH14 retinol dehydrogenase 14 (all-trans/9-cis/11-cis)".

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Belyaeva OV, Kedishvili NY (2002). "Human pancreas protein 2 (PAN2) has a retinal reductase activity and is ubiquitously expressed in human tissues". FEBS Lett. 531 (3): 489–93. Bibcode:2002FEBSL.531..489B. doi: 10.1016/S0014-5793(02)03588-3 . PMID   12435598. S2CID   22343979.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Mehrle A, Rosenfelder H, Schupp I, Del Val C, Arlt D, Hahne F, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.