RENBP

RENBP
Identifiers
Aliases	RENBP , RBP, RNBP, renin binding protein
External IDs	OMIM: 312420 MGI: 105940 HomoloGene: 2184 GeneCards: RENBP
Gene location (Human) Chr. X chromosome (human) [1] Band Xq28 Start 153,935,269 bp [1] End 153,944,687 bp [1]
Gene location (Mouse) Chr. X chromosome (mouse) [2] Band X A7.3|X 37.49 cM Start 72,965,727 bp [2] End 72,974,456 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte spleen upper lobe of left lung right lung tibial nerve right coronary artery kidney sural nerve nucleus accumbens left coronary artery Top expressed in morula yolk sac blastocyst kidney calvaria proximal tubule iris placenta retinal pigment epithelium ciliary body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function enzyme inhibitor activity endopeptidase inhibitor activity catalytic activity isomerase activity ATP binding protein homodimerization activity purine nucleotide binding N-acylglucosamine 2-epimerase activity peptidase inhibitor activity Cellular component extracellular exosome cytosol Biological process N-acetylmannosamine metabolic process regulation of blood pressure N-acetylneuraminate catabolic process negative regulation of catalytic activity negative regulation of endopeptidase activity N-acetylglucosamine metabolic process UDP-N-acetylglucosamine biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5973 19703 Ensembl ENSG00000102032 ENSMUSG00000031387 UniProt P51606 P82343 RefSeq (mRNA) NM_002910 NM_001164704 NM_023132 RefSeq (protein) NP_002901 NP_001158176 NP_075621 Location (UCSC) Chr X: 153.94 – 153.94 Mb Chr X: 72.97 – 72.97 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

N-acylglucosamine 2-epimerase is an enzyme that in humans is encoded by the RENBP gene. ^{[5] [6]}

The gene product inhibits renin activity by forming a dimer with renin, a complex known as high molecular weight renin. The encoded protein contains a leucine zipper domain, which is essential for its dimerization with renin. The gene product can catalyze the interconversion of N-acetylglucosamine to N-acetylmannosamine, indicating that it is a GlcNAc 2-epimerase. Transcript variants utilizing alternative promoters have been described in the literature. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000102032 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031387 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Takahashi S, Inoue H, Miyake Y (Aug 1992). "The human gene for renin-binding protein". J Biol Chem. 267 (18): 13007–13. doi: 10.1016/S0021-9258(18)42374-5 . PMID   1618798.
6. "Entrez Gene: RENBP renin binding protein".

Further reading

• Inoue H, Takahashi S, Fukui K, Miyake Y (1992). "Genetic and molecular properties of human and rat renin-binding proteins with reference to the function of the leucine zipper motif". J. Biochem. 110 (4): 493–500. doi:10.1093/oxfordjournals.jbchem.a123609. PMID   1723410.
• Takahashi S, Miura R, Miyake Y (1985). "A study on renin binding protein (RnBP) in the human kidney". J. Biochem. 97 (2): 671–7. doi:10.1093/oxfordjournals.jbchem.a135103. PMID   3924907.
• Murakami K, Hirose S, Chino S, et al. (1983). "Properties of renin-binding protein". Clinical and Experimental Hypertension, Part A. 4 (11–12): 2073–81. doi:10.3109/10641968209062372. PMID   6756682.
• Faranda S, Frattini A, Vezzoni P (1995). "The human genes encoding renin-binding protein and host cell factor are closely linked in Xq28 and transcribed in the same direction". Gene. 155 (2): 237–9. doi:10.1016/0378-1119(94)00810-F. PMID   7721097.
• van den Ouweland AM, Verdijk M, Kiochis P, et al. (1994). "The human renin-binding protein gene (RENBP) maps in Xq28". Genomics. 21 (1): 279–81. doi:10.1006/geno.1994.1259. PMID   8088804.
• Knöll A, Schunkert H, Reichwald K, et al. (1998). "Human renin binding protein: complete genomic sequence and association of an intronic T/C polymorphism with the prorenin level in males". Hum. Mol. Genet. 6 (9): 1527–34. doi: 10.1093/hmg/6.9.1527 . PMID   9285790.
• Brenner V, Nyakatura G, Rosenthal A, Platzer M (1997). "Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse". Genomics. 44 (1): 8–14. doi:10.1006/geno.1997.4822. PMID   9286695.
• Stäsche R, Hinderlich S, Weise C, et al. (1997). "A bifunctional enzyme catalyzes the first two steps in N-acetylneuraminic acid biosynthesis of rat liver. Molecular cloning and functional expression of UDP-N-acetyl-glucosamine 2-epimerase/N-acetylmannosamine kinase". J. Biol. Chem. 272 (39): 24319–24. doi: 10.1074/jbc.272.39.24319 . PMID   9305888.
• Takahashi S, Takahashi K, Kaneko T, et al. (1999). "Human renin-binding protein is the enzyme N-acetyl-D-glucosamine 2-epimerase". J. Biochem. 125 (2): 348–53. doi:10.1093/oxfordjournals.jbchem.a022293. PMID   9990133.
• Takahashi S, Kumagai M, Shindo S, et al. (2001). "Renin inhibits N-acetyl-D-glucosamine 2-epimerase (renin-binding protein)". J. Biochem. 128 (6): 951–6. doi:10.1093/oxfordjournals.jbchem.a022846. PMID   11098137.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Lapteva N, Nieda M, Ando Y, et al. (2001). "Expression of renin-angiotensin system genes in immature and mature dendritic cells identified using human cDNA microarray". Biochem. Biophys. Res. Commun. 285 (4): 1059–65. doi:10.1006/bbrc.2001.5215. PMID   11467860.
• Takahashi S, Ogasawara H, Takahashi K, et al. (2002). "Identification of a domain conferring nucleotide binding to the N-acetyl-d-glucosamine 2-epimerase (Renin binding protein)". J. Biochem. 131 (4): 605–10. doi:10.1093/oxfordjournals.jbchem.a003140. PMID   11926999.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Luchansky SJ, Yarema KJ, Takahashi S, Bertozzi CR (2003). "GlcNAc 2-epimerase can serve a catabolic role in sialic acid metabolism". J. Biol. Chem. 278 (10): 8035–42. doi: 10.1074/jbc.M212127200 . PMID   12499362.
• Bohlmeyer T, Ferdensi A, Bristow MR, et al. (2003). "Selective activation of N-acyl-D-glucosamine 2-epimerase expression in failing human heart ventricular myocytes". J. Card. Fail. 9 (1): 59–68. doi:10.1054/jcaf.2003.6. PMID   12612874.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.