RGPD5

RGPD5
Identifiers
Aliases	RGPD5 , BS-63, BS63, HEL161, RGP5, RANBP2-like and GRIP domain containing 5, RANBP2 like and GRIP domain containing 5
External IDs	OMIM: 612708 MGI: 894323 HomoloGene: 87808 GeneCards: RGPD5
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q13 Start 109,792,758 bp [1] End 109,857,705 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10 B4|10 29.34 cM Start 58,282,742 bp [2] End 58,330,178 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon sural nerve trachea nipple pylorus bone marrow cells superior surface of tongue saphenous vein corpus callosum trigeminal ganglion Top expressed in lacrimal gland cerebellar vermis spermatocyte spermatid left lung lobe primitive streak pineal gland habenula nucleus accumbens iris More reference expression data BioGPS n/a
Gene ontology Molecular function GTPase activator activity Cellular component cytoplasm nucleus nuclear pore centrosome Biological process intracellular transport NLS-bearing protein import into nucleus positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84220 19386 Ensembl ENSG00000015568 ENSMUSG00000003226 UniProt Q99666 Q9ERU9 RefSeq (mRNA) NM_005054 NM_032260 NM_011240 RefSeq (protein) NP_005045 NP_115636 NP_035370 Location (UCSC) Chr 2: 109.79 – 109.86 Mb Chr 10: 58.28 – 58.33 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

RANBP2-like and GRIP domain-containing protein 5 is a protein that in humans is encoded by the RGPD5 gene. ^{[5] [6] [7]}

RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene shares a high degree of sequence identity with RANBP2, a large RAN-binding protein localized at the cytoplasmic side of the nuclear pore complex. It is believed that this RANBP2 gene family member arose from a duplication event 3 Mb distal to RANBP2. Alternative splicing has been observed for this locus and two variants are described. Additional splicing is suggested but complete sequence for further transcripts has not been determined. ^[7]

Interactions

RGPD5 has been shown to interact with Transportin 1. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000015568 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000003226 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ciccarelli FD, von Mering C, Suyama M, Harrington ED, Izaurralde E, Bork P (March 2005). "Complex genomic rearrangements lead to novel primate gene function". Genome Research. 15 (3): 343–51. doi:10.1101/gr.3266405. PMC   551560 . PMID   15710750.
6. Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, et al. (April 2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi: 10.1038/nature03466 . PMID   15815621.
7. "Entrez Gene: RGPD5 RANBP2-like and GRIP domain containing 5".
8. Cai Y, Miao SY, Wang LF (October 2001). "[Determination of the binding site of testis-specific nucleoporin BS-63 to transportin (karopherin beta 2) and the proof of their combination in vitro]". Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae. 23 (5): 462–6. PMID   12905863.

Further reading

• Cai Y, Miao SY, Wang LF (October 2001). "[Determination of the binding site of testis-specific nucleoporin BS-63 to transportin (karopherin beta 2) and the proof of their combination in vitro]". Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae. 23 (5): 462–6. PMID   12905863.
• Cai Y, Gao Y, Sheng Q, Miao S, Cui X, Wang L, Zong S, Koide SS (January 2002). "Characterization and potential function of a novel testis-specific nucleoporin BS-63". Molecular Reproduction and Development. 61 (1): 126–34. doi:10.1002/mrd.1139. PMID   11774384. S2CID   23631919.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Wang LF, Zhu HD, Miao SY, Cao DF, Wu YW, Zong SD, Koide SS (1999). "Molecular cloning and characterization of a novel testis-specific nucleoporin-related gene". Archives of Andrology. 42 (2): 71–84. doi: 10.1080/014850199262904 . PMID   10101573.
• Nothwang HG, Rensing C, Kübler M, Denich D, Brandl B, Stubanus M, Haaf T, Kurnit D, Hildebrandt F (February 1998). "Identification of a novel Ran binding protein 2 related gene (RANBP2L1) and detection of a gene cluster on human chromosome 2q11-q12". Genomics. 47 (3): 383–92. doi:10.1006/geno.1997.5119. PMID   9480752.