RGS1

RGS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2BV1, 2GTP
Identifiers
Aliases	RGS1 , 1R20, BL34, HEL-S-87, IER1, IR20, regulator of G-protein signaling 1, regulator of G protein signaling 1
External IDs	OMIM: 600323; MGI: 1354694; HomoloGene: 2191; GeneCards: RGS1; OMA:RGS1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q31.2 Start 192,575,763 bp [1] End 192,580,024 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1 F|1 62.56 cM Start 144,118,034 bp [2] End 144,124,980 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in C1 segment olfactory bulb right lung rectum appendix tibial nerve gallbladder lymph node epithelium of nasopharynx right uterine tube Top expressed in stroma of bone marrow mesenteric lymph nodes granulocyte spleen duodenum large intestine colon jejunum pyloric antrum decidua More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G-protein alpha-subunit binding GTPase activator activity calmodulin binding GTPase activity Cellular component extrinsic component of cytoplasmic side of plasma membrane cytosol plasma membrane membrane cytoplasm Biological process G protein-coupled receptor signaling pathway positive regulation of GTPase activity negative regulation of signal transduction leukotriene signaling pathway adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway immune response regulation of G protein-coupled receptor signaling pathway signal transduction response to bacterium Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5996 50778 Ensembl ENSG00000090104 ENSMUSG00000026358 UniProt Q08116 Q9JL25 RefSeq (mRNA) NM_002922 NM_015811 RefSeq (protein) NP_002913 NP_056626 Location (UCSC) Chr 1: 192.58 – 192.58 Mb Chr 1: 144.12 – 144.12 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Regulator of G-protein signaling 1 is a protein that in humans is encoded by the RGS1 gene. ^{[5] [6] [7]}

This gene encodes a member of the regulator of G-protein signaling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000090104 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026358 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Newton JS, Deed RW, Mitchell EL, Murphy JJ, Norton JD (Jan 1994). "A B cell specific immediate early human gene is located on chromosome band 1q31 and encodes an alpha helical basic phosphoprotein". Biochim Biophys Acta. 1216 (2): 314–6. doi:10.1016/0167-4781(93)90163-8. PMID   8241276.
6. Druey KM, Blumer KJ, Kang VH, Kehrl JH (May 1996). "Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family". Nature. 379 (6567): 742–6. Bibcode:1996Natur.379..742D. doi:10.1038/379742a0. PMID   8602223. S2CID   4362632.
7. "Entrez Gene: RGS1 regulator of G-protein signalling 1".

Further reading

• Hong JX, Wilson GL, Fox CH, Kehrl JH (1993). "Isolation and characterization of a novel B cell activation gene". J. Immunol. 150 (9): 3895–904. doi: 10.4049/jimmunol.150.9.3895 . PMID   8473738.
• Heximer SP, Cristillo AD, Forsdyke DR (1997). "Comparison of mRNA expression of two regulators of G-protein signaling, RGS1/BL34/1R20 and RGS2/G0S8, in cultured human blood mononuclear cells". DNA Cell Biol. 16 (5): 589–98. doi:10.1089/dna.1997.16.589. PMID   9174164.
• Bowman EP, Campbell JJ, Druey KM, et al. (1998). "Regulation of chemotactic and proadhesive responses to chemoattractant receptors by RGS (regulator of G-protein signaling) family members". J. Biol. Chem. 273 (43): 28040–8. doi: 10.1074/jbc.273.43.28040 . PMID   9774420.
• Denecke B, Meyerdierks A, Böttger EC (1999). "RGS1 is expressed in monocytes and acts as a GTPase-activating protein for G-protein-coupled chemoattractant receptors". J. Biol. Chem. 274 (38): 26860–8. doi: 10.1074/jbc.274.38.26860 . PMID   10480894.
• Popov SG, Krishna UM, Falck JR, Wilkie TM (2000). "Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity". J. Biol. Chem. 275 (25): 18962–8. doi: 10.1074/jbc.M001128200 . PMID   10747990.
• Zheng B, Chen D, Farquhar MG (2000). "MIR16, a putative membrane glycerophosphodiester phosphodiesterase, interacts with RGS16". Proc. Natl. Acad. Sci. U.S.A. 97 (8): 3999–4004. Bibcode:2000PNAS...97.3999Z. doi: 10.1073/pnas.97.8.3999 . PMC   18131 . PMID   10760272.
• Lou X, Yano H, Lee F, et al. (2001). "GIPC and GAIP Form a Complex with TrkA: A Putative Link between G Protein and Receptor Tyrosine Kinase Pathways". Mol. Biol. Cell. 12 (3): 615–27. doi:10.1091/mbc.12.3.615. PMC   30968 . PMID   11251075.
• Hoffmann M, Ward RJ, Cavalli A, et al. (2001). "Differential capacities of the RGS1, RGS16 and RGS-GAIP regulators of G protein signaling to enhance alpha2A-adrenoreceptor agonist-stimulated GTPase activity of G(o1)alpha". J. Neurochem. 78 (4): 797–806. doi: 10.1046/j.1471-4159.2001.00479.x . PMID   11520900.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Le Y, Honczarenko M, Glodek AM, et al. (2005). "CXC chemokine ligand 12-induced focal adhesion kinase activation and segregation into membrane domains is modulated by regulator of G protein signaling 1 in pro-B cells". J. Immunol. 174 (5): 2582–90. doi: 10.4049/jimmunol.174.5.2582 . PMID   15728464.
• Han JI, Huang NN, Kim DU, Kehrl JH (2006). "RGS1 and RGS13 mRNA silencing in a human B lymphoma line enhances responsiveness to chemoattractants and impairs desensitization". J. Leukoc. Biol. 79 (6): 1357–68. doi:10.1189/jlb.1105693. PMID   16565322. S2CID   39672919.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.