RHPN2

RHPN2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2VSV
Identifiers
Aliases	RHPN2 , P76RBE, RHOBP, rhophilin, Rho GTPase binding protein 2, rhophilin Rho GTPase binding protein 2
External IDs	OMIM: 617932; MGI: 1289234; HomoloGene: 12407; GeneCards: RHPN2; OMA:RHPN2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q13.11 Start 32,978,592 bp [1] End 33,064,888 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7 B2|7 21.36 cM Start 35,033,595 bp [2] End 35,091,714 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic epithelial cell pancreatic ductal cell mucosa of ileum oocyte bronchial epithelial cell mucosa of sigmoid colon parotid gland secondary oocyte jejunal mucosa germinal epithelium Top expressed in secondary oocyte primary oocyte zygote parotid gland submandibular gland epithelium of stomach lacrimal gland left colon migratory enteric neural crest cell vestibular membrane of cochlear duct More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 85415 52428 Ensembl ENSG00000131941 ENSMUSG00000030494 UniProt Q8IUC4 Q8BWR8 RefSeq (mRNA) NM_033103 NM_027897 RefSeq (protein) NP_149094 NP_082173 Location (UCSC) Chr 19: 32.98 – 33.06 Mb Chr 7: 35.03 – 35.09 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Rhophilin-2 is a protein that in humans is encoded by the RHPN2 gene. ^{[5] [6]}

Interactions

RHPN2 has been shown to interact with RHOB. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000131941 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030494 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Peck JW, Oberst M, Bouker KB, Bowden E, Burbelo PD (November 2002). "The RhoA-binding protein, rhophilin-2, regulates actin cytoskeleton organization". J. Biol. Chem. 277 (46): 43924–32. doi: 10.1074/jbc.M203569200 . PMID   12221077.
6. "Entrez Gene: RHPN2 rhophilin, Rho GTPase binding protein 2".
7. Mircescu H, Steuve S, Savonet V, Degraef C, Mellor H, Dumont JE, Maenhaut C, Pirson I (December 2002). "Identification and characterization of a novel activated RhoB binding protein containing a PDZ domain whose expression is specifically modulated in thyroid cells by cAMP" (PDF). Eur. J. Biochem. 269 (24): 6241–9. doi:10.1046/j.1432-1033.2002.03343.x. hdl:2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/51241. PMID   12473120. S2CID   23901713.

Further reading

• Mircescu H, Steuve S, Savonet V, Degraef C, Mellor H, Dumont JE, Maenhaut C, Pirson I (2002). "Identification and characterization of a novel activated RhoB binding protein containing a PDZ domain whose expression is specifically modulated in thyroid cells by cAMP" (PDF). Eur. J. Biochem. 269 (24): 6241–9. doi:10.1046/j.1432-1033.2002.03343.x. hdl:2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/51241. PMID   12473120. S2CID   23901713.
• Jaffe AB, Aspenström P, Hall A (2004). "Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways". Mol. Cell. Biol. 24 (4): 1736–46. doi:10.1128/MCB.24.4.1736-1746.2004. PMC   344169 . PMID   14749388.
• Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID   15761153. S2CID   39457788.
• Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi: 10.1074/mcp.M500021-MCP200 . PMID   15778465.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Zhan X, Desiderio DM (2006). "Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry". Anal. Biochem. 354 (2): 279–89. doi:10.1016/j.ab.2006.05.024. PMID   16777052.
• Steuve S, Devosse T, Lauwers E, Vanderwinden JM, André B, Courtoy PJ, Pirson I (2006). "Rhophilin-2 is targeted to late-endosomal structures of the vesicular machinery in the presence of activated RhoB". Exp. Cell Res. 312 (20): 3981–9. doi:10.1016/j.yexcr.2006.08.028. PMID   17054945.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1) 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.