RILP (gene)

RILP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1YHN
Identifiers
Aliases	RILP , PP10141, Rab interacting lysosomal protein
External IDs	OMIM: 607848; MGI: 2144271; HomoloGene: 19596; GeneCards: RILP; OMA:RILP - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17p13.3 Start 1,646,145 bp [1] End 1,649,866 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 B5 Start 75,400,920 bp [2] End 75,403,994 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart muscle of thigh left ventricle right lobe of thyroid gland gastrocnemius muscle left lobe of thyroid gland blood right auricle of heart mucosa of transverse colon skeletal muscle tissue Top expressed in interventricular septum Epithelium of choroid plexus medial head of gastrocnemius muscle soleus muscle myocardium of ventricle knee joint quadriceps femoris muscle digastric muscle sternocleidomastoid muscle tibialis anterior muscle More reference expression data BioGPS n/a
Gene ontology Molecular function dynein light intermediate chain binding protein binding small GTPase binding protein dimerization activity Cellular component endosome late endosome phagocytic vesicle membrane membrane late endosome membrane lysosomal membrane lysosome cytoplasmic vesicle cytosol ciliary basal body protein-containing complex cytoplasm Biological process positive regulation of protein catabolic process antigen processing and presentation of exogenous peptide antigen via MHC class II endosome transport via multivesicular body sorting pathway negative regulation of protein catabolic process endosome to lysosome transport early endosome to late endosome transport intralumenal vesicle formation regulation of multivesicular body size protein transport cilium assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 83547 280408 Ensembl ENSG00000274145 ENSG00000167705 ENSMUSG00000038195 UniProt Q96NA2 Q5ND29 RefSeq (mRNA) NM_031430 NM_001029938 RefSeq (protein) NP_113618 NP_001025109 Location (UCSC) Chr 17: 1.65 – 1.65 Mb Chr 11: 75.4 – 75.4 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Rab-interacting lysosomal protein is a protein that in humans is encoded by the RILP gene. ^{[5] [6]}

Function

RILP, along with the GTPase RAB7 (MIM 602298), controls late endocytic transport.[supplied by OMIM] ^[6]

Interactions

RILP (gene) has been shown to interact with RAB7A. ^{[5] [7]}

References

1. ENSG00000167705 GRCh38: Ensembl release 89: ENSG00000274145, ENSG00000167705 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038195 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Cantalupo G, Alifano P, Roberti V, Bruni CB, Bucci C (February 2001). "Rab-interacting lysosomal protein (RILP): the Rab7 effector required for transport to lysosomes". EMBO J. 20 (4): 683–93. doi:10.1093/emboj/20.4.683. PMC   145419 . PMID   11179213.
6. "Entrez Gene: RILP Rab interacting lysosomal protein".
7. Caplan S, Hartnell LM, Aguilar RC, Naslavsky N, Bonifacino JS (July 2001). "Human Vam6p promotes lysosome clustering and fusion in vivo". J. Cell Biol. 154 (1): 109–22. doi:10.1083/jcb.200102142. PMC   2196876 . PMID   11448994.

Further reading

• Bucci C, De Gregorio L, Bruni CB (2001). "Expression analysis and chromosomal assignment of PRA1 and RILP genes". Biochem. Biophys. Res. Commun. 286 (4): 815–9. doi:10.1006/bbrc.2001.5466. PMID   11520070.
• Jordens I, Fernandez-Borja M, Marsman M, Dusseljee S, Janssen L, Calafat J, Janssen H, Wubbolts R, Neefjes J (2002). "The Rab7 effector protein RILP controls lysosomal transport by inducing the recruitment of dynein-dynactin motors". Curr. Biol. 11 (21): 1680–5. doi: 10.1016/S0960-9822(01)00531-0 . PMID   11696325. S2CID   14642826.
• Wang T, Hong W (2003). "Interorganellar Regulation of Lysosome Positioning by the Golgi Apparatus through Rab34 Interaction with Rab-interacting Lysosomal Protein". Mol. Biol. Cell. 13 (12): 4317–32. doi:10.1091/mbc.E02-05-0280. PMC   138636 . PMID   12475955.
• Cardoso C, Leventer RJ, Ward HL, Toyo-Oka K, Chung J, Gross A, Martin CL, Allanson J, Pilz DT, Olney AH, Mutchinick OM, Hirotsune S, Wynshaw-Boris A, Dobyns WB, Ledbetter DH (2003). "Refinement of a 400-kb Critical Region Allows Genotypic Differentiation between Isolated Lissencephaly, Miller-Dieker Syndrome, and Other Phenotypes Secondary to Deletions of 17p13.3". Am. J. Hum. Genet. 72 (4): 918–30. doi:10.1086/374320. PMC   1180354 . PMID   12621583.
• Harrison RE, Bucci C, Vieira OV, Schroer TA, Grinstein S (2003). "Phagosomes Fuse with Late Endosomes and/or Lysosomes by Extension of Membrane Protrusions along Microtubules: Role of Rab7 and RILP". Mol. Cell. Biol. 23 (18): 6494–506. doi:10.1128/MCB.23.18.6494-6506.2003. PMC   193691 . PMID   12944476.
• Wang T, Wong KK, Hong W (2004). "A Unique Region of RILP Distinguishes It from Its Related Proteins in Its Regulation of Lysosomal Morphology and Interaction with Rab7 and Rab34". Mol. Biol. Cell. 15 (2): 815–26. doi:10.1091/mbc.E03-06-0413. PMC   329395 . PMID   14668488.
• Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi: 10.1073/pnas.0404089101 . PMC   524842 . PMID   15498874.
• Wu M, Wang T, Loh E, Hong W, Song H (2005). "Structural basis for recruitment of RILP by small GTPase Rab7". EMBO J. 24 (8): 1491–501. doi:10.1038/sj.emboj.7600643. PMC   1142575 . PMID   15933719.
• Colucci AM, Campana MC, Bellopede M, Bucci C (2005). "The Rab-interacting lysosomal protein, a Rab7 and Rab34 effector, is capable of self-interaction". Biochem. Biophys. Res. Commun. 334 (1): 128–33. doi:10.1016/j.bbrc.2005.06.067. PMID   15996637.
• Shimojo M, Hersh LB (2006). "Characterization of the REST/NRSF-interacting LIM domain protein (RILP): localization and interaction with REST/NRSF". J. Neurochem. 96 (4): 1130–8. doi: 10.1111/j.1471-4159.2005.03608.x . PMID   16417580. S2CID   6893975.
• Marsman M, Jordens I, Rocha N, Kuijl C, Janssen L, Neefjes J (2006). "A splice variant of RILP induces lysosomal clustering independent of dynein recruitment". Biochem. Biophys. Res. Commun. 344 (3): 747–56. doi:10.1016/j.bbrc.2006.03.178. PMID   16631113.
• Progida C, Spinosa MR, De Luca A, Bucci C (2006). "RILP interacts with the VPS22 component of the ESCRT-II complex". Biochem. Biophys. Res. Commun. 347 (4): 1074–9. doi:10.1016/j.bbrc.2006.07.007. PMID   16857164.