RIN1

RIN1
Identifiers
Aliases	RIN1 , Ras and Rab interactor 1
External IDs	OMIM: 605965 MGI: 2385695 HomoloGene: 3170 GeneCards: RIN1
Gene location (Human)
Chr.	Chromosome 11 (human)
End	66,336,840 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	5,107,099 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; olfactory bulb; ; skin of abdomen; ; vena cava; ; nucleus accumbens; ; putamen; ; external globus pallidus; ; caudate nucleus; ; stromal cell of endometrium; ; right uterine tube;
	Top expressed in
	nucleus accumbens; ; superior frontal gyrus; ; hippocampus proper; ; prefrontal cortex; ; olfactory tubercle; ; amygdala; ; spermatid; ; Region I of hippocampus proper; ; subiculum; ; lip;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ; GTPase activator activity ;
Cellular component	cytoplasm ; plasma membrane ; cytoskeleton ; membrane ; cytosol ; dendrite ; neuronal cell body ;
Biological process	positive regulation of GTPase activity ; endocytosis ; signal transduction ; memory ; associative learning ; negative regulation of synaptic plasticity ;
	Sources:Amigo / QuickGO
Orthologs
	9610
	225870
	ENSG00000174791
	ENSMUSG00000024883
	Q13671
	Q921Q7
	NM_004292 ; NM_001363559 ; NM_001363560
	NM_145495 ; NM_001374051 ; NM_001374052
	NP_004283 ; NP_001350488 ; NP_001350489
	NP_663470 ; NP_001360980 ; NP_001360981
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated April 12, 2024

Ras and Rab interactor 1 is a protein that in humans is encoded by the RIN1 gene.^[5]^[6]^[7]

Interactions

RIN1 has been shown to interact with HRAS.^[8]^[9]

Additionally, RIN1 binds and activates ABL family tyrosine kinases.

Related Research Articles

Tyrosine-protein kinase ABL1 also known as ABL1 is a protein that, in humans, is encoded by the ABL1 gene located on chromosome 9. c-Abl is sometimes used to refer to the version of the gene found within the mammalian genome, while v-Abl refers to the viral gene, which was initially isolated from the Abelson murine leukemia virus.

Growth factor receptor-bound protein 10 also known as insulin receptor-binding protein Grb-IR is a protein that in humans is encoded by the GRB10 gene.

Tyrosine-protein kinase HCK is an enzyme that in humans is encoded by the HCK gene.

RAS p21 protein activator 1 or RasGAP, also known as RASA1, is a 120-kDa cytosolic human protein that provides two principal activities:

M-phase inducer phosphatase 1 also known as dual specificity phosphatase Cdc25A is a protein that in humans is encoded by the cell division cycle 25 homolog A (CDC25A) gene.

Docking protein 1 is a protein that in humans is encoded by the DOK1 gene.

Protein tyrosine kinase 2 beta is an enzyme that in humans is encoded by the PTK2B gene.

Abl interactor 1 also known as Abelson interactor 1 (Abi-1) is a protein that in humans is encoded by the ABI1 gene.

Cytoplasmic protein NCK1 is a protein that in humans is encoded by the NCK1 gene.

Tyrosine-protein phosphatase non-receptor type 12 is an enzyme that in humans is encoded by the PTPN12 gene.

Tyrosine-protein phosphatase non-receptor type 2 is an enzyme that in humans is encoded by the PTPN2 gene.

Tyrosine-protein kinase ABL2 also known as Abelson-related gene (Arg) is an enzyme that in humans is encoded by the ABL2 gene.

Proto-oncogene tyrosine-protein kinase FER is an enzyme that in humans is encoded by the FER gene.

Ras-related protein R-Ras is a protein that in humans is encoded by the RRAS gene.

Cytoplasmic tyrosine-protein kinase BMX is an enzyme that in humans is encoded by the BMX gene.

Docking protein 2 is a protein that in humans is encoded by the DOK2 gene.

Ras-related protein R-Ras2 is a protein that in humans is encoded by the RRAS2 gene.

Protein tyrosine phosphatase type IVA 1 is an enzyme that in humans is encoded by the PTP4A1 gene.

Growth factor receptor-bound protein 14 is a protein that in humans is encoded by the GRB14 gene.

Fibroblast growth factor receptor substrate 3 is a protein that in humans is encoded by the FRS3 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000174791 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024883 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Han L, Wong D, Dhaka A, Afar D, White M, Xie W, et al. (Jun 1997). "Protein binding and signaling properties of RIN1 suggest a unique effector function". Proc Natl Acad Sci U S A. 94 (10): 4954–9. Bibcode:1997PNAS...94.4954H. doi: 10.1073/pnas.94.10.4954 . PMC 24612 . PMID 9144171.
↑ Colicelli J, Nicolette C, Birchmeier C, Rodgers L, Riggs M, Wigler M (May 1991). "Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae". Proc Natl Acad Sci U S A. 88 (7): 2913–7. Bibcode:1991PNAS...88.2913C. doi: 10.1073/pnas.88.7.2913 . PMC 51350 . PMID 1849280.
↑ "Entrez Gene: RIN1 Ras and Rab interactor 1".
↑ Mitin NY, Ramocki Melissa B, Zullo Alfred J, Der Channing J, Konieczny Stephen F, Taparowsky Elizabeth J (May 2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization". J. Biol. Chem. 279 (21). United States: 22353–61. doi: 10.1074/jbc.M312867200 . ISSN 0021-9258. PMID 15031288.
↑ Han L, Colicelli J (Mar 1995). "A human protein selected for interference with Ras function interacts directly with Ras and competes with Raf1". Mol. Cell. Biol. 15 (3). UNITED STATES: 1318–23. doi:10.1128/mcb.15.3.1318. ISSN 0270-7306. PMC 230355 . PMID 7862125.

Dkaha A, Costa RM, Hu H, Irvin DK, Patel A, Kornblum HI, et al. (2003). "The RAS effector RIN1 modulates the formation of aversive memories". J. Neurosci. 23 (3): 748–757. doi:10.1523/JNEUROSCI.23-03-00748.2003. PMC 6741936 . PMID 12574403.
Trowbridge IS, Lesley J, Trotter J, Hyman R (1985). "Thymocyte subpopulation enriched for progenitors with an unrearranged T-cell receptor beta-chain gene". Nature. 315 (6021): 666–9. Bibcode:1985Natur.315..666T. doi:10.1038/315666a0. PMID 3874369. S2CID 20469621.
Han L, Colicelli J (1995). "A human protein selected for interference with Ras function interacts directly with Ras and competes with Raf1". Mol. Cell. Biol. 15 (3): 1318–23. doi:10.1128/mcb.15.3.1318. PMC 230355 . PMID 7862125.
Afar DE, Han L, McLaughlin J, Wong S, Dhaka A, Parmar K, et al. (1997). "Regulation of the oncogenic activity of BCR-ABL by a tightly bound substrate protein RIN1". Immunity. 6 (6): 773–82. doi: 10.1016/S1074-7613(00)80452-5 . PMID 9208849.
Tall GG, Barbieri MA, Stahl PD, Horazdovsky BF (2001). "Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1". Dev. Cell. 1 (1): 73–82. doi: 10.1016/S1534-5807(01)00008-9 . PMID 11703925.
Wang Y, Waldron RT, Dhaka A, Patel A, Riley MM, Rozengurt E, et al. (2002). "The RAS Effector RIN1 Directly Competes with RAF and Is Regulated by 14-3-3 Proteins". Mol. Cell. Biol. 22 (3): 916–26. doi:10.1128/MCB.22.3.916-926.2001. PMC 133556 . PMID 11784866.
Murphy GA, Graham SM, Morita S, Reks SE, Rogers-Graham K, Vojtek A, et al. (2002). "Involvement of phosphatidylinositol 3-kinase, but not RalGDS, in TC21/R-Ras2-mediated transformation". J. Biol. Chem. 277 (12): 9966–75. doi: 10.1074/jbc.M109059200 . PMID 11788587.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Mitin NY, Ramocki MB, Zullo AJ, Der CJ, Konieczny SF, Taparowsky EJ (2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization". J. Biol. Chem. 279 (21): 22353–61. doi: 10.1074/jbc.M312867200 . PMID 15031288.
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Hu H, Bliss JM, Wang Y, Colicelli J (2005). "RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration". Curr. Biol. 15 (9): 815–23. Bibcode:2005CBio...15..815H. doi: 10.1016/j.cub.2005.03.049 . PMID 15886098. S2CID 6736561.
Zhang Y, Wolf-Yadlin A, Ross PL, Pappin DJ, Rush J, Lauffenburger DA, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell. Proteomics. 4 (9): 1240–50. doi: 10.1074/mcp.M500089-MCP200 . PMID 15951569.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Hunker CM, Giambini H, Galvis A, Hall J, Kruk I, Veisaga M, et al. (2006). "Rin1 regulates insulin receptor signal transduction pathways". Exp. Cell Res. 312 (7): 1106–18. doi:10.1016/j.yexcr.2005.12.021. PMID 16457816.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Senda K, Goi T, Hirono Y, Katayama K, Yamaguchi A (2007). "Analysis of RIN1 gene expression in colorectal cancer". Oncol. Rep. 17 (5): 1171–5. doi: 10.3892/or.17.5.1171 . PMID 17390061.
Kong C, Su X, Chen PI, Stahl PD (2007). "Rin1 interacts with signal-transducing adaptor molecule (STAM) and mediates epidermal growth factor receptor trafficking and degradation". J. Biol. Chem. 282 (20): 15294–301. doi: 10.1074/jbc.M611538200 . PMID 17403676.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000174791 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024883 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9144171-5] Han L, Wong D, Dhaka A, Afar D, White M, Xie W, et al. (Jun 1997). "Protein binding and signaling properties of RIN1 suggest a unique effector function". Proc Natl Acad Sci U S A. 94 (10): 4954–9. Bibcode:1997PNAS...94.4954H. doi: 10.1073/pnas.94.10.4954 . PMC 24612 . PMID 9144171.

[pmid1849280-6] Colicelli J, Nicolette C, Birchmeier C, Rodgers L, Riggs M, Wigler M (May 1991). "Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae". Proc Natl Acad Sci U S A. 88 (7): 2913–7. Bibcode:1991PNAS...88.2913C. doi: 10.1073/pnas.88.7.2913 . PMC 51350 . PMID 1849280.

[entrez-7] "Entrez Gene: RIN1 Ras and Rab interactor 1".

[pmid15031288-8] Mitin NY, Ramocki Melissa B, Zullo Alfred J, Der Channing J, Konieczny Stephen F, Taparowsky Elizabeth J (May 2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization". J. Biol. Chem. 279 (21). United States: 22353–61. doi: 10.1074/jbc.M312867200 . ISSN 0021-9258. PMID 15031288.

[pmid7862125-9] Han L, Colicelli J (Mar 1995). "A human protein selected for interference with Ras function interacts directly with Ras and competes with Raf1". Mol. Cell. Biol. 15 (3). UNITED STATES: 1318–23. doi:10.1128/mcb.15.3.1318. ISSN 0270-7306. PMC 230355 . PMID 7862125.

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RIN1

Contents

Interactions

Related Research Articles

References

Further reading