RIOX2

RIOX2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XDV, 4BU2, 4BXF
Identifiers
Aliases	RIOX2 , MDIG, MINA53, NO52, ROX, MINA, MYC-induced nuclear antigen, MYC induced nuclear antigen, ribosomal oxygenase 2, JMJD10
External IDs	OMIM: 612049; MGI: 1914264; HomoloGene: 12071; GeneCards: RIOX2; OMA:RIOX2 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3q11.2 Start 97,941,818 bp [1] End 97,972,457 bp [1]
Gene location (Mouse) Chr. Chromosome 16 (mouse) [2] Band 16|16 C1.3 Start 59,292,138 bp [2] End 59,312,824 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte right lobe of thyroid gland left lobe of thyroid gland oral cavity buccal mucosa cell internal globus pallidus parotid gland body of pancreas tendon of biceps brachii Skeletal muscle tissue of rectus abdominis Top expressed in otic placode saccule otic vesicle primitive streak epiblast sternocleidomastoid muscle temporal muscle digastric muscle embryo right kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity dioxygenase activity metal ion binding histone demethylase activity identical protein binding histone H3-methyl-lysine-4 demethylase activity histone H3-methyl-lysine-36 demethylase activity transcription corepressor activity Cellular component nucleolus transcription regulator complex nucleus nucleoplasm cytosol Biological process regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated negative regulation of transcription, DNA-templated histone demethylation chromatin remodeling peptidyl-arginine hydroxylation histone H3-K4 demethylation ribosome biogenesis histone H3-K36 demethylation negative regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84864 67014 Ensembl ENSG00000170854 ENSMUSG00000022724 UniProt Q8IUF8 Q8CD15 RefSeq (mRNA) NM_001042533 NM_001261829 NM_032778 NM_153182 NM_025910 RefSeq (protein) NP_001035998 NP_001248758 NP_116167 NP_694822 NP_080186 Location (UCSC) Chr 3: 97.94 – 97.97 Mb Chr 16: 59.29 – 59.31 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ribosomal oxygenase 2 is a protein that in humans is encoded by the RIOX2 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000170854 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022724 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tsuneoka M, Koda Y, Soejima M, Teye K, Kimura H (Sep 2002). "A novel myc target gene, mina53, that is involved in cell proliferation". J Biol Chem. 277 (38): 35450–9. doi: 10.1074/jbc.M204458200 . PMID   12091391.
6. "Entrez Gene: MINA MYC induced nuclear antigen".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Teye K, Tsuneoka M, Arima N, et al. (2004). "Increased Expression of a Myc Target Gene Mina53 in Human Colon Cancer". Am. J. Pathol. 164 (1): 205–16. doi:10.1016/S0002-9440(10)63111-2. PMC   1602225 . PMID   14695334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Eilbracht J, Reichenzeller M, Hergt M, et al. (2004). "NO66, a Highly Conserved Dual Location Protein in the Nucleolus and in a Special Type of Synchronously Replicating Chromatin". Mol. Biol. Cell. 15 (4): 1816–32. doi:10.1091/mbc.E03-08-0623. PMC   379278 . PMID   14742713.
• Tsuneoka M, Fujita H, Arima N, et al. (2005). "Mina53 as a potential prognostic factor for esophageal squamous cell carcinoma". Clin. Cancer Res. 10 (21): 7347–56. doi: 10.1158/1078-0432.CCR-03-0543 . PMID   15534111.
• Eilbracht J, Kneissel S, Hofmann A, Schmidt-Zachmann MS (2005). "Protein NO52--a constitutive nucleolar component sharing high sequence homologies to protein NO66". Eur. J. Cell Biol. 84 (2–3): 279–94. doi:10.1016/j.ejcb.2004.12.022. PMID   15819408.
• Zhang Y, Lu Y, Yuan BZ, et al. (2005). "The Human mineral dust-induced gene, mdig, is a cell growth regulating gene associated with lung cancer". Oncogene. 24 (31): 4873–82. doi:10.1038/sj.onc.1208668. PMID   15897898. S2CID   24239327.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Teye K, Arima N, Nakamura Y, et al. (2007). "Expression of Myc target gene mina53 in subtypes of human lymphoma". Oncol. Rep. 18 (4): 841–8. doi: 10.3892/or.18.4.841 . PMID   17786344.
• Ishizaki H, Yano H, Tsuneoka M, et al. (2007). "Overexpression of the myc target gene Mina53 in advanced renal cell carcinoma". Pathol. Int. 57 (10): 672–80. doi:10.1111/j.1440-1827.2007.02156.x. PMID   17803656. S2CID   20991987.