RIT2

RIT2
Identifiers
Aliases	RIT2 , RIBA, RIN, ROC2, Ras like without CAAX 2
External IDs	OMIM: 609592; MGI: 108054; HomoloGene: 2198; GeneCards: RIT2; OMA:RIT2 - orthologs
Gene location (Human) Chr. Chromosome 18 (human) [1] Band 18q12.3 Start 42,743,227 bp [1] End 43,115,691 bp [1]
Gene location (Mouse) Chr. Chromosome 18 (mouse) [2] Band 18|18 B1 Start 31,106,542 bp [2] End 31,450,343 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar cortex cerebellar hemisphere right hemisphere of cerebellum cerebellar vermis endothelial cell Brodmann area 9 prefrontal cortex nucleus accumbens hypothalamus right frontal lobe Top expressed in ventral tegmental area dorsal tegmental nucleus dorsomedial hypothalamic nucleus medial vestibular nucleus habenula suprachiasmatic nucleus central gray substance of midbrain paraventricular nucleus of hypothalamus arcuate nucleus deep cerebellar nuclei More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding calmodulin binding identical protein binding GTP binding protein binding semaphorin receptor binding chromatin binding GTPase activity GDP binding Cellular component membrane membrane raft plasma membrane nucleus neuron projection cytoplasm cell body dendritic tree Biological process chemical synaptic transmission signal transduction MAPK cascade maintenance of protein location in cell regulation of endocytosis intracellular signal transduction regulation of protein phosphorylation Ras protein signal transduction positive regulation of neuron projection development negative regulation of neuron projection development regulation of Cdc42 protein signal transduction positive regulation of MAPK cascade positive regulation of transcription by RNA polymerase II regulation of calcium-mediated signaling small GTPase mediated signal transduction adenylate cyclase-activating G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6014 19762 Ensembl ENSG00000152214 ENSMUSG00000057455 UniProt Q99578 P70425 RefSeq (mRNA) NM_002930 NM_001272077 NM_009065 RefSeq (protein) NP_001259006 NP_002921 NP_033091 Location (UCSC) Chr 18: 42.74 – 43.12 Mb Chr 18: 31.11 – 31.45 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

GTP-binding protein Rit2 is a protein that in humans is encoded by the RIT2 gene. ^{[5] [6] [7]}

RIN belongs to the RAS (HRAS; MIM 190020) superfamily of small GTPases (Shao et al., 1999).[supplied by OMIM] ^[7]

RIT2 has been associated with Parkinson's disease in two large genetic studies. ^{[8] [9]} An gene expression study of postmortem brain has suggested RIT2 interacts with interferon-γ signalling. ^[10]

Interactions

RIT2 has been shown to interact with POU4F1. ^[11]

References

1. GRCh38: Ensembl release 89: ENSG00000152214 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000057455 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lee CH, Della NG, Chew CE, Zack DJ (November 1996). "Rin, a neuron-specific and calmodulin-binding small G-protein, and Rit define a novel subfamily of ras proteins". The Journal of Neuroscience. 16 (21): 6784–94. doi:10.1523/JNEUROSCI.16-21-06784.1996. PMC   6579259 . PMID   8824319.
6. Wes PD, Yu M, Montell C (November 1996). "RIC, a calmodulin-binding Ras-like GTPase". The EMBO Journal. 15 (21): 5839–48. doi:10.1002/j.1460-2075.1996.tb00971.x. PMC   452332 . PMID   8918462.
7. "Entrez Gene: RIT2 Ras-like without CAAX 2".
8. Pankratz N, Beecham GW, DeStefano AL, Dawson TM, Doheny KF, Factor SA, Hamza TH, Hung AY, Hyman BT, Ivinson AJ, Krainc D, Latourelle JC, Clark LN, Marder K, Martin ER, Mayeux R, Ross OA, Scherzer CR, Simon DK, Tanner C, Vance JM, Wszolek ZK, Zabetian CP, Myers RH, Payami H, Scott WK, Foroud T (March 2012). "Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2". Annals of Neurology. 71 (3): 370–84. doi:10.1002/ana.22687. PMC   3354734 . PMID   22451204.
9. Nalls MA, Pankratz N, Lill CM, Do CB, Hernandez DG, Saad M, et al. (September 2014). "Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease" (PDF). Nature Genetics. 46 (9): 989–93. doi:10.1038/ng.3043. hdl:11858/00-001M-0000-0026-AA42-8. PMC   4146673 . PMID   25064009.
10. Liscovitch N, French L (2014). "Differential Co-Expression between α-Synuclein and IFN-γ Signaling Genes across Development and in Parkinson's Disease". PLOS ONE. 9 (12): e115029. Bibcode:2014PLoSO...9k5029L. doi: 10.1371/journal.pone.0115029 . PMC   4262449 . PMID   25493648.
11. Calissano M, Latchman DS (August 2003). "Functional interaction between the small GTP-binding protein Rin and the N-terminal of Brn-3a transcription factor". Oncogene. 22 (35): 5408–14. doi:10.1038/sj.onc.1206635. PMID   12934100. S2CID   670567.

Further reading

• Shao H, Kadono-Okuda K, Finlin BS, Andres DA (November 1999). "Biochemical characterization of the Ras-related GTPases Rit and Rin". Archives of Biochemistry and Biophysics. 371 (2): 207–19. doi:10.1006/abbi.1999.1448. PMID   10545207.
• Hoshino M, Nakamura S (July 2002). "The Ras-like small GTP-binding protein Rin is activated by growth factor stimulation". Biochemical and Biophysical Research Communications. 295 (3): 651–6. doi:10.1016/S0006-291X(02)00731-3. PMID   12099688.
• Calissano M, Latchman DS (August 2003). "Functional interaction between the small GTP-binding protein Rin and the N-terminal of Brn-3a transcription factor". Oncogene. 22 (35): 5408–14. doi:10.1038/sj.onc.1206635. PMID   12934100. S2CID   670567.
• Hartwig C, Veske A, Krejcova S, Rosenberger G, Finckh U (August 2005). "Plexin B3 promotes neurite outgrowth, interacts homophilically, and interacts with Rin". BMC Neuroscience. 6: 53. doi: 10.1186/1471-2202-6-53 . PMC   1215486 . PMID   16122393.
• Shi GX, Han J, Andres DA (November 2005). "Rin GTPase couples nerve growth factor signaling to p38 and b-Raf/ERK pathways to promote neuronal differentiation". The Journal of Biological Chemistry. 280 (45): 37599–609. doi: 10.1074/jbc.M507364200 . PMID   16157584.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.