RLF (gene)

RLF
Identifiers
Aliases	RLF , ZN-15L, ZNF292L, rearranged L-myc fusion, RLF zinc finger
External IDs	OMIM: 180610; MGI: 1924705; HomoloGene: 8243; GeneCards: RLF; OMA:RLF - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p34.2 Start 40,161,387 bp [1] End 40,240,921 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 D2.2 Start 121,002,570 bp [2] End 121,072,281 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte cartilage tissue Achilles tendon ventricular zone sperm endothelial cell testicle embryo ganglionic eminence middle temporal gyrus Top expressed in saccule Rostral migratory stream otic placode granulocyte otic vesicle Gonadal ridge tail of embryo genital tubercle lumbar spinal ganglion hand More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding zinc ion binding protein binding metal ion binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process positive regulation of transcription, DNA-templated regulation of transcription, DNA-templated DNA integration chromosome organization transcription, DNA-templated positive regulation of transcription by RNA polymerase II regulation of DNA methylation histone H3-K4 monomethylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6018 109263 Ensembl ENSG00000117000 ENSMUSG00000049878 UniProt Q13129 n/a RefSeq (mRNA) NM_012421 NM_001081013 NM_001346660 RefSeq (protein) NP_036553 n/a Location (UCSC) Chr 1: 40.16 – 40.24 Mb Chr 4: 121 – 121.07 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Zinc finger protein Rlf is a protein that in humans is encoded by the RLF gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000117000 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000049878 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Makela TP, Kere J, Winqvist R, Alitalo K (Aug 1991). "Intrachromosomal rearrangements fusing L-myc and rlf in small-cell lung cancer". Mol Cell Biol. 11 (8): 4015–21. doi:10.1128/mcb.11.8.4015. PMC   361204 . PMID   1649386.
6. "Entrez Gene: RLF rearranged L-myc fusion".

Further reading

• Olsen JV; Blagoev B; Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Gregory SG; Barlow KF; McLay KE; et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.
• Swick L, Kapatos G (2006). "A yeast 2-hybrid analysis of human GTP cyclohydrolase I protein interactions". J. Neurochem. 97 (5): 1447–55. doi:10.1111/j.1471-4159.2006.03836.x. PMC   2239266 . PMID   16696853.
• Gerhard DS; Wagner L; Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Colland F; Jacq X; Trouplin V; et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC   442148 . PMID   15231748.
• Lanigan TM; Liu A; Huang YZ; et al. (2003). "Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf". FASEB J. 17 (14): 2048–60. doi: 10.1096/fj.02-1096com . hdl: 2027.42/154294 . PMID   14597674. S2CID   22523818.
• Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Shao H, Kadono-Okuda K, Finlin BS, Andres DA (1999). "Biochemical characterization of the Ras-related GTPases Rit and Rin". Arch. Biochem. Biophys. 371 (2): 207–19. doi:10.1006/abbi.1999.1448. PMID   10545207.
• Mäkelä TP; Hellsten E; Vesa J; et al. (1996). "The rearranged L-myc fusion gene (RLF) encodes a Zn-15 related zinc finger protein". Oncogene. 11 (12): 2699–704. PMID   8545128.