RNASET2

RNASET2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3T0O
Identifiers
Aliases	RNASET2 , RNASE6PL, bA514O12.3, ribonuclease T2
External IDs	OMIM: 612944 MGI: 3702087 HomoloGene: 31190 GeneCards: RNASET2
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6q27 Start 166,922,113 bp [1] End 166,957,191 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17|17 A1 Start 7,238,033 bp [2] End 7,278,698 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube blood monocyte spleen parotid gland seminal vesicula olfactory bulb lymph node inferior ganglion of vagus nerve periodontal fiber Top expressed in lip esophagus morula superior frontal gyrus yolk sac secondary oocyte spermatid proximal tubule mirror thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function hydrolase activity ribonuclease T2 activity endonuclease activity nuclease activity RNA binding ribonuclease activity endoribonuclease activity Cellular component lysosomal lumen endoplasmic reticulum lumen lysosome endoplasmic reticulum extracellular exosome extracellular region extracellular space azurophil granule lumen Biological process nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic RNA catabolic process RNA phosphodiester bond hydrolysis neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8635 68195 Ensembl ENSG00000026297 ENSMUSG00000094724 UniProt O00584 Q5FWA0 RefSeq (mRNA) NM_003730 NM_017795 NM_018726 NM_026611 NM_029204 RefSeq (protein) NP_003721 NP_080887 NP_001077407 NP_080887 Location (UCSC) Chr 6: 166.92 – 166.96 Mb Chr 17: 7.24 – 7.28 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ribonuclease T2 is an enzyme that in humans is encoded by the RNASET2 gene. ^{[5] [6]} It is a type of endoribonuclease.

This ribonuclease gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement. ^[6] RNASET2 has been reported as a tumour associated antigen in anaplastic large cell lymphoma and other lymphomas. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000026297 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000094724 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Trubia M, Sessa L, Taramelli R (Sep 1997). "Mammalian Rh/T2/S-glycoprotein ribonuclease family genes: cloning of a human member located in a region of chromosome 6 (6q27) frequently deleted in human malignancies". Genomics. 42 (2): 342–344. doi:10.1006/geno.1997.4679. PMID   9192857.
6. "Entrez Gene: RNASET2 ribonuclease T2".
7. Patel S, Chen H, Monti L, Gould E, Haralambieva E, Schmid J, Toomey D, Woessmann W, Roncador G, Hatton CS, Liggins AP, Taramelli R, Banham AH, Acquati F, Murphy D, Pulford K (Sep 2012). "RNASET2 - An autoantigen in anaplastic large cell lymphoma identified by protein array analysis". J Proteomics. 75 (17): 5279–5292. doi:10.1016/j.jprot.2012.06.009. PMID   22732457.

Further reading

• Acquati F, Morelli C, Cinquetti R, et al. (2001). "Cloning and characterization of a senescence inducing and class II tumor suppressor gene in ovarian carcinoma at chromosome region 6q27". Oncogene. 20 (8): 980–988. doi: 10.1038/sj.onc.1204178 . PMID   11314033.
• Liu Y, Emilion G, Mungall AJ, et al. (2002). "Physical and transcript map of the region between D6S264 and D6S149 on chromosome 6q27, the minimal region of allele loss in sporadic epithelial ovarian cancer". Oncogene. 21 (3): 387–399. doi: 10.1038/sj.onc.1205067 . PMID   11821951.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–811. Bibcode:2003Natur.425..805M. doi: 10.1038/nature02055 . PMID   14574404.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Acquati F, Possati L, Ferrante L, et al. (2005). "Tumor and metastasis suppression by the human RNASET2 gene". Int. J. Oncol. 26 (5): 1159–68. doi:10.3892/ijo.26.5.1159. PMID   15809705.
• Campomenosi P, Salis S, Lindqvist C, et al. (2006). "Characterization of RNASET2, the first human member of the Rh/T2/S family of glycoproteins". Arch. Biochem. Biophys. 449 (1–2): 17–26. doi:10.1016/j.abb.2006.02.022. PMID   16620762.
• Patel S, Chen H, Monti L, Gould E, Haralambieva E, Schmid J, Toomey D, Woessmann W, Roncador G, Hatton CS, Liggins AP, Taramelli R, Banham AH, Acquati F, Murphy D, Pulford K (2012). "RNASET2 - An autoantigen in anaplastic large cell lymphoma identified by protein array analysis". J Proteomics. 75 (17): 5279–5292. doi:10.1016/j.jprot.2012.06.009. PMID   22732457.