RNF114

RNF114
Identifiers
Aliases	RNF114 , PSORS12, ZNF313, ring finger protein 114
External IDs	OMIM: 612451 MGI: 1933159 HomoloGene: 10265 GeneCards: RNF114
Gene location (Human)
Chr.	Chromosome 20 (human)
End	49,953,885 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	167,358,093 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; pancreatic ductal cell; ; palpebral conjunctiva; ; sperm; ; monocyte; ; glomerulus; ; gastrocnemius muscle; ; amniotic fluid; ; metanephric glomerulus;
	Top expressed in
	secondary oocyte; ; Paneth cell; ; renal corpuscle; ; blood; ; medial ganglionic eminence; ; medullary collecting duct; ; substantia nigra; ; right lung lobe; ; urothelium; ; spermatocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	ubiquitin conjugating enzyme binding ; ubiquitin protein ligase activity ; metal ion binding ; ubiquitin-protein transferase activity ; transferase activity ;
Cellular component	cytoplasm ; intracellular anatomical structure ; nucleus ; cytosol ; plasma membrane ;
Biological process	multicellular organism development ; cell differentiation ; positive regulation of proteasomal ubiquitin-dependent protein catabolic process ; protein ubiquitination ; spermatogenesis ; protein polyubiquitination ;
	Sources:Amigo / QuickGO
Orthologs
	55905
	81018
	ENSG00000124226
	ENSMUSG00000006418
	Q9Y508
	Q9ET26
	NM_018683
	NM_030743 ; NM_001356496 ; NM_001360930
	NP_061153
	NP_109668 ; NP_001347859
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

E3 ubiquitin-protein ligase RNF114 is a protein that in humans is encoded by the RNF114 gene.^[5]^[6]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000124226 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006418 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Bijlmakers MJ, Kanneganti SK, Barker JN, Trembath RC, Capon F (August 2011). "Functional analysis of the RNF114 psoriasis susceptibility gene implicates innate immune responses to double-stranded RNA in disease pathogenesis". Human Molecular Genetics. 20 (16): 3129–37. doi:10.1093/hmg/ddr215. PMC 3140818 . PMID 21571784.
↑ Yang P, Lu Y, Li M, Zhang K, Li C, Chen H, Tao D, Zhang S, Ma Y (June 2014). "Identification of RNF114 as a novel positive regulatory protein for T cell activation". Immunobiology. 219 (6): 432–9. doi:10.1016/j.imbio.2014.02.002. PMID 24631332.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000124226 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006418 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Bijlmakers_2011-5] Bijlmakers MJ, Kanneganti SK, Barker JN, Trembath RC, Capon F (August 2011). "Functional analysis of the RNF114 psoriasis susceptibility gene implicates innate immune responses to double-stranded RNA in disease pathogenesis". Human Molecular Genetics. 20 (16): 3129–37. doi:10.1093/hmg/ddr215. PMC 3140818 . PMID 21571784.

[Yang_2014-6] Yang P, Lu Y, Li M, Zhang K, Li C, Chen H, Tao D, Zhang S, Ma Y (June 2014). "Identification of RNF114 as a novel positive regulatory protein for T cell activation". Immunobiology. 219 (6): 432–9. doi:10.1016/j.imbio.2014.02.002. PMID 24631332.

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