RNF12

RLIM
Identifiers
Aliases	RLIM , NY-REN-43, RNF12, ring finger protein, LIM domain interacting, MRX61, TOKAS
External IDs	OMIM: 300379 MGI: 1342291 HomoloGene: 7920 GeneCards: RLIM
Gene location (Human) Chr. X chromosome (human) [1] Band Xq13.2 Start 74,582,976 bp [1] End 74,614,624 bp [1]
Gene location (Mouse) Chr. X chromosome (mouse) [2] Band X 46.42 cM|X D Start 103,000,769 bp [2] End 103,024,890 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus Achilles tendon Brodmann area 46 postcentral gyrus internal globus pallidus entorhinal cortex Brodmann area 23 superior frontal gyrus tibia caput epididymis Top expressed in cumulus cell internal carotid artery external carotid artery ectoderm otic placode pineal gland secondary oocyte saccule left lung lobe barrel cortex More reference expression data BioGPS n/a
Gene ontology Molecular function transcription corepressor activity metal ion binding transferase activity ubiquitin-protein transferase activity ubiquitin protein ligase activity protein binding Cellular component transcription repressor complex nucleus cytosol nucleoplasm Biological process negative regulation of transcription, DNA-templated transcription, DNA-templated protein ubiquitination proteasome-mediated ubiquitin-dependent protein catabolic process protein polyubiquitination regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II ubiquitin-dependent protein catabolic process negative regulation of DNA-binding transcription factor activity random inactivation of X chromosome regulation of dosage compensation by inactivation of X chromosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51132 19820 Ensembl ENSG00000131263 ENSMUSG00000056537 UniProt Q9NVW2 Q9WTV7 RefSeq (mRNA) NM_183353 NM_016120 NM_011276 NM_001358205 RefSeq (protein) NP_057204 NP_899196 NP_035406 NP_001345134 Location (UCSC) Chr X: 74.58 – 74.61 Mb Chr X: 103 – 103.02 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

E3 ubiquitin-protein ligase RLIM is an enzyme that in humans is encoded by the RLIM gene. ^{[5] [6]}

Function

The protein encoded by this gene is a RING-H2 zinc finger protein. It has been shown to be a ubiquitin protein ligase that targets LIM domain binding 1 (LDB1/CLIM), and causes proteasome-dependent degradation of LDB1. This protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor. Alternatively spliced transcript variants encoding the same protein have been reported. ^[6] Functions in female mice as a regulator of X chromosome inactivation .

Interactions

RNF12 has been shown to interact with Estrogen receptor alpha. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000131263 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000056537 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jäger D, Jäger E, Knuth A, Chen YT, Old LJ (Nov 1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer. 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID   10508479. S2CID   21839750.
6. "Entrez Gene: RNF12 ring finger protein 12".
7. Johnsen SA, Güngör C, Prenzel T, Riethdorf S, Riethdorf L, Taniguchi-Ishigaki N, Rau T, Tursun B, Furlow JD, Sauter G, Scheffner M, Pantel K, Gannon F, Bach I (Jan 2009). "Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer". Cancer Res. 69 (1): 128–36. doi:10.1158/0008-5472.CAN-08-1630. PMC   2713826 . PMID   19117995.

Further reading

• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Hiratani I, Yamamoto N, Mochizuki T, Ohmori SY, Taira M (2003). "Selective degradation of excess Ldb1 by Rnf12/RLIM confers proper Ldb1 expression levels and Xlim-1/Ldb1 stoichiometry in Xenopus organizer functions". Development. 130 (17): 4161–75. doi:10.1242/dev.00621. PMID   12874135. S2CID   18111062.
• Ostendorff HP, Peirano RI, Peters MA, Schlüter A, Bossenz M, Scheffner M, Bach I (2002). "Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors". Nature. 416 (6876): 99–103. Bibcode:2002Natur.416...99O. doi:10.1038/416099a. PMID   11882901. S2CID   4426785.
• Ostendorff HP, Bossenz M, Mincheva A, Copeland NG, Gilbert DJ, Jenkins NA, Lichter P, Bach I (2000). "Functional characterization of the gene encoding RLIM, the corepressor of LIM homeodomain factors". Genomics. 69 (1): 120–30. doi:10.1006/geno.2000.6311. PMID   11013082.
• Bach I, Rodriguez-Esteban C, Carrière C, Bhushan A, Krones A, Rose DW, Glass CK, Andersen B, Izpisúa Belmonte JC, Rosenfeld MG (1999). "RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex". Nat. Genet. 22 (4): 394–9. doi:10.1038/11970. PMID   10431247. S2CID   22326394.
• Shin J, Bossenz M, Chung Y, Ma H, Byron M, Taniguchi-Ishigaki N, Zhu X, Jiao B, Hall LL, Green MR, Jones SN, Hermans-Borgmeyer I, Lawrence JB, Bach I (2010). "Maternal Rnf12/RLIM is required for imprinted X-chromosome inactivation in mice". Nature. 467 (7318): 977–81. Bibcode:2010Natur.467..977S. doi:10.1038/nature09457. PMC   2967734 . PMID   20962847.
• Jiao B, Taniguchi-Ishigaki N, Güngör C, Peters MA, Chen YW, Riethdorf S, Drung A, Ahronian LG, Shin J, Pagnis R, Pantel K, Tachibana T, Lewis BC, Johnsen SA, Bach I (2013). "Functional activity of RLIM/Rnf12 is regulated by phosphorylation-dependent nucleocytoplasmic shuttling". Mol Biol Cell. 24 (19): 3085–96. doi:10.1091/mbc.E13-05-0239. PMC   3784382 . PMID   23904271.