RNF123

RNF123
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MA6
Identifiers
Aliases	RNF123 , KPC1, FP1477, ring finger protein 123
External IDs	OMIM: 614472 MGI: 2148796 HomoloGene: 11112 GeneCards: RNF123
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3p21.31 Start 49,689,538 bp [1] End 49,721,529 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 F1 Start 107,928,733 bp [2] End 107,960,545 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle vastus lateralis muscle right lobe of liver triceps brachii muscle body of tongue biceps brachii thoracic diaphragm deltoid muscle tibialis anterior muscle prefrontal cortex Top expressed in saccule mirror otic placode cerebellar cortex skeletal muscle tissue triceps brachii muscle extraocular muscle sternocleidomastoid muscle interventricular septum temporal muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding transferase activity ubiquitin-protein transferase activity Cellular component cytoplasm cytosol nuclear membrane Biological process protein ubiquitination protein deubiquitination proteolysis involved in cellular protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 63891 84585 Ensembl ENSG00000164068 ENSMUSG00000041528 UniProt Q5XPI4 Q5XPI3 RefSeq (mRNA) NM_022064 NM_032543 NM_001311152 RefSeq (protein) NP_071347 NP_001298081 NP_115932 Location (UCSC) Chr 3: 49.69 – 49.72 Mb Chr 9: 107.93 – 107.96 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

E3 ubiquitin-protein ligase RNF123 is an enzyme that in humans is encoded by the RNF123 gene. ^[5]

The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. ^[5] Increased expression of the gene has been associated with laminopathies, and in degradation of chromatin associated proteins such as HP1 (Chaturvedi et al, 2012, PMID: 23077635).

See also

• RING finger domain

References

1. GRCh38: Ensembl release 89: ENSG00000164068 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000041528 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: RNF123 ring finger protein 123".

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC   442148 . PMID   15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi: 10.1073/pnas.0404089101 . PMC   524842 . PMID   15498874.
• Kamura T, Hara T, Matsumoto M, et al. (2005). "Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase". Nat. Cell Biol. 6 (12): 1229–35. doi:10.1038/ncb1194. PMID   15531880. S2CID   12225217.
• Kotoshiba S, Kamura T, Hara T, et al. (2005). "Molecular dissection of the interaction between p27 and Kip1 ubiquitylation-promoting complex, the ubiquitin ligase that regulates proteolysis of p27 in G1 phase". J. Biol. Chem. 280 (18): 17694–700. doi: 10.1074/jbc.M500866200 . PMID   15746103.
• Hara T, Kamura T, Kotoshiba S, et al. (2005). "Role of the UBL-UBA protein KPC2 in degradation of p27 at G1 phase of the cell cycle". Mol. Cell. Biol. 25 (21): 9292–303. doi:10.1128/MCB.25.21.9292-9303.2005. PMC   1265808 . PMID   16227581.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.

External links

• RNF123+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)