RNF125

RNF125
Identifiers
Aliases	RNF125 , TRAC-1, TRAC1, TNORS, ring finger protein 125, E3 ubiquitin protein ligase, ring finger protein 125
External IDs	OMIM: 610432; MGI: 1914914; HomoloGene: 32369; GeneCards: RNF125; OMA:RNF125 - orthologs
Gene location (Human) Chr. Chromosome 18 (human) [1] Band 18q12.1 Start 32,018,825 bp [1] End 32,073,219 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa oocyte secondary oocyte parietal pleura mucosa of sigmoid colon superficial temporal artery visceral pleura white blood cell monocyte inferior ganglion of vagus nerve n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding p53 binding protein binding transferase activity zinc ion binding ubiquitin conjugating enzyme binding ubiquitin protein ligase activity Cellular component intracellular membrane-bounded organelle membrane Golgi membrane Golgi apparatus VCP-NPL4-UFD1 AAA ATPase complex Biological process adaptive immune response positive regulation of proteasomal ubiquitin-dependent protein catabolic process protein ubiquitination immune system process ubiquitin-dependent protein catabolic process negative regulation of type I interferon production negative regulation of RIG-I signaling pathway protein polyubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54941 67664 Ensembl ENSG00000101695 ENSMUSG00000033107 UniProt Q96EQ8 Q9D9R0 RefSeq (mRNA) NM_017831 NM_026301 NM_001364973 RefSeq (protein) NP_060301 NP_080577 NP_001351902 Location (UCSC) Chr 18: 32.02 – 32.07 Mb n/a PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

E3 ubiquitin-protein ligase RNF125 is an enzyme that in humans is encoded by the RNF125 gene. ^[4]

This gene encodes a novel E3 ubiquitin ligase that contains an N-terminal RING finger domain. The encoded protein may function as a positive regulator in the T-cell receptor signaling pathway. ^[4]

References

1. GRCh38: Ensembl release 89: ENSG00000101695 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: RNF125 ring finger protein 125".

Further reading

• Giannini AL, Gao Y, Bijlmakers MJ (2008). "T-cell regulator RNF125/TRAC-1 belongs to a novel family of ubiquitin ligases with zinc fingers and a ubiquitin-binding domain". Biochem. J. 410 (1): 101–11. doi:10.1042/BJ20070995. PMC   2733222 . PMID   17990982.
• Shoji-Kawata S, Zhong Q, Kameoka M, et al. (2007). "The RING finger ubiquitin ligase RNF125/TRAC-1 down-modulates HIV-1 replication in primary human peripheral blood mononuclear cells". Virology. 368 (1): 191–204. doi: 10.1016/j.virol.2007.06.028 . PMID   17643463.
• Zhao H, Li CC, Pardo J, et al. (2005). "A novel E3 ubiquitin ligase TRAC-1 positively regulates T cell activation". J. Immunol. 174 (9): 5288–97. doi: 10.4049/jimmunol.174.9.5288 . PMID   15843525.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Chu P, Pardo J, Zhao H, et al. (2004). "Systematic identification of regulatory proteins critical for T-cell activation". J. Biol. 2 (3): 21. doi: 10.1186/1475-4924-2-21 . PMC   333404 . PMID   12974981.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Saurin AJ, Borden KL, Boddy MN, Freemont PS (1996). "Does this have a familiar RING?". Trends Biochem. Sci. 21 (6): 208–14. doi:10.1016/s0968-0004(96)80017-x. PMID   8744354.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.