RNF125

RNF125
Identifiers
Aliases	RNF125 , TRAC-1, TRAC1, TNORS, ring finger protein 125, E3 ubiquitin protein ligase, ring finger protein 125
External IDs	OMIM: 610432 HomoloGene: 32369 GeneCards: RNF125
Gene location (Human)
Chr.	Chromosome 18 (human)
End	32,073,219 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; oocyte; ; secondary oocyte; ; parietal pleura; ; superficial temporal artery; ; visceral pleura; ; monocyte; ; inferior ganglion of vagus nerve; ; duodenum; ; trigeminal ganglion;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding ; p53 binding ; protein binding ; transferase activity ; zinc ion binding ; ubiquitin conjugating enzyme binding ; ubiquitin protein ligase activity ;
Cellular component	intracellular membrane-bounded organelle ; membrane ; Golgi membrane ; Golgi apparatus ; VCP-NPL4-UFD1 AAA ATPase complex ;
Biological process	adaptive immune response ; positive regulation of proteasomal ubiquitin-dependent protein catabolic process ; protein ubiquitination ; immune system process ; ubiquitin-dependent protein catabolic process ; negative regulation of type I interferon production ; negative regulation of RIG-I signaling pathway ; protein polyubiquitination ;
	Sources:Amigo / QuickGO
Orthologs
	54941
	n/a
	ENSG00000101695
	n/a
	Q96EQ8
	n/a
	NM_017831
	n/a
	NP_060301
	n/a
	Wikidata
View/Edit Human

Last updated March 05, 2023

E3 ubiquitin-protein ligase RNF125 is an enzyme that in humans is encoded by the RNF125 gene.^[3]

This gene encodes a novel E3 ubiquitin ligase that contains an N-terminal RING finger domain. The encoded protein may function as a positive regulator in the T-cell receptor signaling pathway.^[3]

Related Research Articles

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E3 ubiquitin-protein ligase BRE1A is an enzyme that in humans is encoded by the RNF20 gene.

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E3 ubiquitin-protein ligase RNF19A is an enzyme that in humans is encoded by the RNF19A gene.

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RING finger protein 31 is a protein that in humans is encoded by the RNF31 gene.

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E3 ubiquitin-protein ligase RNF34 is an enzyme that in humans is encoded by the RNF34 gene.

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RING finger protein 220 is a protein that in humans is encoded by the RNF220 gene.

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RNF144A is an E3 ubiquitin ligase belonging to the RING-between RING (RBR) family of ubiquitin ligases, whose specific members have been shown to function as RING-HECT hybrid E3 ligases. RNF144A is most closely related to RNF144B at the protein level, and the two proteins together comprise a subdomain within the RBR family of proteins. The ubiquitin ligase activity of RNF144A catalyzes ubiquitin linkages at the K6-, K11- and K48- positions of ubiquitin in vitro, and is regulated by self-association through its transmembrane domain.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000101695 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: RNF125 ring finger protein 125".

Giannini AL, Gao Y, Bijlmakers MJ (2008). "T-cell regulator RNF125/TRAC-1 belongs to a novel family of ubiquitin ligases with zinc fingers and a ubiquitin-binding domain". Biochem. J. 410 (1): 101–11. doi:10.1042/BJ20070995. PMC 2733222 . PMID 17990982.
Shoji-Kawata S, Zhong Q, Kameoka M, et al. (2007). "The RING finger ubiquitin ligase RNF125/TRAC-1 down-modulates HIV-1 replication in primary human peripheral blood mononuclear cells". Virology. 368 (1): 191–204. doi: 10.1016/j.virol.2007.06.028 . PMID 17643463.
Zhao H, Li CC, Pardo J, et al. (2005). "A novel E3 ubiquitin ligase TRAC-1 positively regulates T cell activation". J. Immunol. 174 (9): 5288–97. doi: 10.4049/jimmunol.174.9.5288 . PMID 15843525.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Chu P, Pardo J, Zhao H, et al. (2004). "Systematic identification of regulatory proteins critical for T-cell activation". J. Biol. 2 (3): 21. doi:10.1186/1475-4924-2-21. PMC 333404 . PMID 12974981.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Saurin AJ, Borden KL, Boddy MN, Freemont PS (1996). "Does this have a familiar RING?". Trends Biochem. Sci. 21 (6): 208–14. doi:10.1016/s0968-0004(96)80017-x. PMID 8744354.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000101695 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] 1 2 "Entrez Gene: RNF125 ring finger protein 125".

[1]

[2]

[3]

RNF125

Related Research Articles

References

Further reading