RNF139

RNF139
Identifiers
Aliases	RNF139 , HRCA1, RCA1, TRC8, ring finger protein 139
External IDs	OMIM: 603046 MGI: 1923091 HomoloGene: 5222 GeneCards: RNF139
Gene location (Human) Chr. Chromosome 8 (human) [1] Band 8q24.13 Start 124,474,880 bp [1] End 124,488,618 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 D1 Start 58,761,078 bp [2] End 58,778,906 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm endothelial cell parietal pleura visceral pleura synovial joint Achilles tendon monocyte parotid gland biceps brachii placenta Top expressed in seminiferous tubule medullary collecting duct spermatid renal corpuscle interventricular septum otolith organ utricle knee joint spermatocyte hand More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ubiquitin protein ligase activity zinc ion binding metal ion binding ubiquitin-protein transferase activity ubiquitin-like protein transferase activity protease binding protein binding transferase activity ligase activity signaling receptor activity Cellular component integral component of membrane membrane endoplasmic reticulum Derlin-1 retrotranslocation complex endoplasmic reticulum membrane endoplasmic reticulum quality control compartment endomembrane system Biological process negative regulation of translation ERAD pathway regulation of ER to Golgi vesicle-mediated transport regulation of protein ubiquitination protein polyubiquitination regulation of protein processing positive regulation of ubiquitin-dependent protein catabolic process protein destabilization protein ubiquitination negative regulation of cell population proliferation proteasome-mediated ubiquitin-dependent protein catabolic process endoplasmic reticulum mannose trimming signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11236 75841 Ensembl ENSG00000170881 ENSMUSG00000037075 UniProt Q8WU17 Q7TMV1 RefSeq (mRNA) NM_007218 NM_175226 RefSeq (protein) NP_009149 NP_780435 Location (UCSC) Chr 8: 124.47 – 124.49 Mb Chr 15: 58.76 – 58.78 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

RING finger protein 139, also known as TRC8, is a protein that in humans is encoded by the RNF139 gene. ^{[5] [6]}

The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medullary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP]. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000170881 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037075 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gemmill RM, West JD, Boldog F, Tanaka N, Robinson LJ, Smith DI, Li F, Drabkin HA (Sep 1998). "The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8". Proc Natl Acad Sci U S A. 95 (16): 9572–7. Bibcode:1998PNAS...95.9572G. doi: 10.1073/pnas.95.16.9572 . PMC   21380 . PMID   9689122.
6. "Entrez Gene: RNF139 ring finger protein 139".

Further reading

• Poland KS, Azim M, Folsom M, et al. (2007). "A constitutional balanced t(3;8)(p14;q24.1) translocation results in disruption of the TRC8 gene and predisposition to clear cell renal cell carcinoma". Genes Chromosomes Cancer. 46 (9): 805–12. doi: 10.1002/gcc.20466 . PMID   17539022. S2CID   44344160.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Brauweiler A, Lorick KL, Lee JP, et al. (2007). "RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene". Oncogene. 26 (16): 2263–71. doi:10.1038/sj.onc.1210017. PMID   17016439. S2CID   12979173.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gemmill RM, Bemis LT, Lee JP, et al. (2002). "The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway". Oncogene. 21 (22): 3507–16. doi:10.1038/sj.onc.1205437. PMID   12032852. S2CID   9964634.
• Lorick KL, Jensen JP, Fang S, et al. (1999). "RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11364–9. Bibcode:1999PNAS...9611364L. doi: 10.1073/pnas.96.20.11364 . PMC   18039 . PMID   10500182.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.