RNF167

RNF167
Identifiers
Aliases	RNF167 , 5730408C10Rik, RING105, LP2254, ring finger protein 167
External IDs	OMIM: 610431; MGI: 1917760; HomoloGene: 41046; GeneCards: RNF167; OMA:RNF167 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17p13.2 Start 4,940,008 bp [1] End 4,945,222 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 B3 Start 70,538,061 bp [2] End 70,542,247 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte apex of heart mucosa of transverse colon left testis right testis muscle layer of sigmoid colon right lobe of thyroid gland anterior pituitary skin of abdomen right hemisphere of cerebellum Top expressed in granulocyte thymus lactiferous gland lip spleen right lung mesenteric lymph nodes right lung lobe neural layer of retina duodenum More reference expression data BioGPS n/a
Gene ontology Molecular function zinc ion binding protein binding metal ion binding ubiquitin-protein transferase activity transferase activity ubiquitin protein ligase activity Cellular component cytoplasm integral component of membrane membrane endomembrane system Biological process negative regulation of cell cycle protein polyubiquitination protein ubiquitination ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26001 70510 Ensembl ENSG00000108523 ENSMUSG00000040746 UniProt Q9H6Y7 Q91XF4 RefSeq (mRNA) NM_015528 NM_001320356 NM_001320357 NM_001320358 NM_001320359 NM_001320360 NM_001320361 NM_001320362 NM_001320363 NM_001320364 NM_001320365 NM_001370303 NM_001370304 NM_001370305 NM_001370306 NM_001370307 NM_001370308 NM_001370311 NM_001370313 NM_001375485 NM_027445 NM_001316728 NM_001363134 RefSeq (protein) NP_001307285 NP_001307286 NP_001307287 NP_001307288 NP_001307289 NP_001307290 NP_001307291 NP_001307292 NP_001307293 NP_001307294 NP_056343 NP_001357232 NP_001357233 NP_001357234 NP_001357235 NP_001357236 NP_001357237 NP_001357240 NP_001357242 NP_001362414 NP_001303657 NP_081721 NP_001350063 Location (UCSC) Chr 17: 4.94 – 4.95 Mb Chr 11: 70.54 – 70.54 Mb PubMed search [3] [4]
Wikidata
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Ring finger protein 167 is a protein that in humans is encoded by the RNF167 gene. ^[5]

Function

RNF167 is an E3 ubiquitin ligase that interacts with TSSC5 (SLC22A18; MIM 602631) and, together with UBCH6 (UBE2E1; MIM 602916), facilitates TSSC5 polyubiquitylation. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000108523 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040746 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Ring finger protein 167" . Retrieved 2018-09-10.
6. Yamada, H. Y.; Gorbsky, G. J. (March 2006). "Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105". Oncogene. 25 (9): 1330–1339. doi:10.1038/sj.onc.1209167. ISSN   1476-5594. PMC   2713668 .

Further reading

• Lussier MP, Herring BE, Nasu-Nishimura Y, Neutzner A, Karbowski M, Youle RJ, Nicoll RA, Roche KW (November 2012). "Ubiquitin ligase RNF167 regulates AMPA receptor-mediated synaptic transmission". Proc. Natl. Acad. Sci. U.S.A. 109 (47): 19426–31. Bibcode:2012PNAS..10919426L. doi: 10.1073/pnas.1217477109 . PMC   3511152 . PMID   23129617.
• Yamazaki Y, Schönherr C, Varshney GK, Dogru M, Hallberg B, Palmer RH (February 2013). "Goliath family E3 ligases regulate the recycling endosome pathway via VAMP3 ubiquitylation". EMBO J. 32 (4): 524–37. doi:10.1038/emboj.2013.1. PMC   3579141 . PMID   23353890.
• van Dijk JR, Yamazaki Y, Palmer RH (April 2014). "Tumour-associated mutations of PA-TM-RING ubiquitin ligases RNF167/RNF13 identify the PA domain as a determinant for endosomal localization". Biochem. J. 459 (1): 27–36. doi:10.1042/BJ20131067. PMID   24387786.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.