RNF20

RNF20
Identifiers
Aliases	RNF20 , BRE1, BRE1A, hBRE1, ring finger protein 20
External IDs	OMIM: 607699 MGI: 1925927 HomoloGene: 5571 GeneCards: RNF20
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9q31.1 Start 101,533,853 bp [1] End 101,563,344 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 B1 Start 49,632,006 bp [2] End 49,656,887 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibialis anterior muscle deltoid muscle caput epididymis bronchial epithelial cell parietal pleura retinal pigment epithelium corpus callosum corpus epididymis Achilles tendon superior vestibular nucleus Top expressed in blood seminal vesicula secondary oocyte maxillary prominence renal corpuscle cumulus cell hair follicle cerebellar vermis primitive streak urothelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription coactivator activity histone binding p53 binding chromatin binding metal ion binding mRNA 3'-UTR binding protein binding ubiquitin protein ligase binding transferase activity ubiquitin-protein transferase activity Cellular component ubiquitin ligase complex HULC complex nucleolus nucleus nucleoplasm Biological process regulation of transcription, DNA-templated negative regulation of mRNA polyadenylation positive regulation of histone methylation ubiquitin-dependent protein catabolic process protein polyubiquitination positive regulation of transcription, DNA-templated negative regulation of cell migration regulation of mitotic cell cycle histone H2B ubiquitination positive regulation of histone H2B ubiquitination histone ubiquitination protein ubiquitination histone monoubiquitination chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56254 109331 Ensembl ENSG00000155827 ENSMUSG00000028309 UniProt Q5VTR2 Q5DTM8 RefSeq (mRNA) NM_019592 NM_001163263 NM_182999 NM_001356401 RefSeq (protein) NP_062538 NP_001156735 NP_892044 NP_001343330 Location (UCSC) Chr 9: 101.53 – 101.56 Mb Chr 4: 49.63 – 49.66 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

E3 ubiquitin-protein ligase BRE1A is an enzyme that in humans is encoded by the RNF20 gene. ^{[5] [6] [7] [8] [9]}

The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. Yeast BRE1 is a ubiquitin ligase required for the ubiquitination of histone H2B and the methylation of histone H3. ^[9]

See also

• RING finger domain

References

1. GRCh38: Ensembl release 89: ENSG00000155827 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028309 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kim J, Hake SB, Roeder RG (Dec 2005). "The human homolog of yeast BRE1 functions as a transcriptional coactivator through direct activator interactions". Mol Cell. 20 (5): 759–70. doi: 10.1016/j.molcel.2005.11.012 . PMID   16337599.
6. Wood A, Schneider J, Dover J, Johnston M, Shilatifard A (Sep 2003). "The Paf1 complex is essential for histone monoubiquitination by the Rad6-Bre1 complex, which signals for histone methylation by COMPASS and Dot1p". J Biol Chem. 278 (37): 34739–42. doi: 10.1074/jbc.C300269200 . PMID   12876294.
7. Shema E, Tirosh I, Aylon Y, Huang J, Ye C, Moskovits N, Raver-Shapira N, Minsky N, Pirngruber J, Tarcic G, Hublarova P, Moyal L, Gana-Weisz M, Shiloh Y, Yarden Y, Johnsen SA, Vojtesek B, Berger SL, Oren M (Oct 2008). "The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression". Genes Dev. 22 (19): 2664–76. doi:10.1101/gad.1703008. PMC   2559905 . PMID   18832071.
8. Liu Z, Oh SM, Okada M, Liu X, Cheng D, Peng J, Brat DJ, Sun SY, Zhou W, Gu W, Ye K (Feb 2009). "Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor". Mol Biol Cell. 20 (3): 757–68. doi:10.1091/mbc.E08-09-0983. PMC   2633391 . PMID   19037095.
9. "Entrez Gene: RNF20 ring finger protein 20".

Further reading

• Lossos IS, Alizadeh AA, Eisen MB, et al. (2000). "Ongoing immunoglobulin somatic mutation in germinal center B cell-like but not in activated B cell-like diffuse large cell lymphomas". Proc. Natl. Acad. Sci. U.S.A. 97 (18): 10209–13. Bibcode:2000PNAS...9710209L. doi: 10.1073/pnas.180316097 . PMC   27813 . PMID   10954754.
• Slachta CA, Jeevanandam V, Goldman B, et al. (2000). "Coronary arteries from human cardiac allografts with chronic rejection contain oligoclonal T cells: persistence of identical clonally expanded TCR transcripts from the early post-transplantation period (endomyocardial biopsies) to chronic rejection (coronary arteries)". J. Immunol. 165 (6): 3469–83. doi: 10.4049/jimmunol.165.6.3469 . PMID   10975868.
• Lee J, Monson NL, Lipsky PE (2001). "The V lambda J lambda repertoire in human fetal spleen: evidence for positive selection and extensive receptor editing". J. Immunol. 165 (11): 6322–33. doi: 10.4049/jimmunol.165.11.6322 . PMID   11086069.
• Rowley AH, Shulman ST, Spike BT, et al. (2001). "Oligoclonal IgA response in the vascular wall in acute Kawasaki disease". J. Immunol. 166 (2): 1334–43. doi: 10.4049/jimmunol.166.2.1334 . PMID   11145718.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Hwang WW, Venkatasubrahmanyam S, Ianculescu AG, et al. (2003). "A conserved RING finger protein required for histone H2B monoubiquitination and cell size control". Mol. Cell. 11 (1): 261–6. doi: 10.1016/S1097-2765(02)00826-2 . PMID   12535538.
• Wood A, Krogan NJ, Dover J, et al. (2003). "Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter". Mol. Cell. 11 (1): 267–74. doi: 10.1016/S1097-2765(02)00802-X . PMID   12535539.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC   2734081 . PMID   15164053.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID   15635413. S2CID   4344740.
• Zhu B, Zheng Y, Pham AD, et al. (2006). "Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation". Mol. Cell. 20 (4): 601–11. doi: 10.1016/j.molcel.2005.09.025 . PMID   16307923.

External links

• RNF20+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)