RNF24

RNF24
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EP4
Identifiers
Aliases	RNF24 , G1L, ring finger protein 24
External IDs	OMIM: 612489 MGI: 1261771 HomoloGene: 5223 GeneCards: RNF24
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20p13 Start 3,927,309 bp [1] End 4,015,558 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2 F1|2 63.32 cM Start 131,139,984 bp [2] End 131,194,812 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte blood pericardium nipple renal medulla stromal cell of endometrium trigeminal ganglion endothelial cell spinal ganglia monocyte Top expressed in secondary oocyte otolith organ utricle kidney seminiferous tubule ganglionic eminence hand proximal tubule medial ganglionic eminence condyle More reference expression data BioGPS n/a
Gene ontology Molecular function zinc ion binding protein binding ubiquitin protein ligase activity metal ion binding Cellular component integral component of membrane Golgi membrane membrane Golgi apparatus endomembrane system Biological process protein polyubiquitination proteasome-mediated ubiquitin-dependent protein catabolic process protein ubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11237 51902 Ensembl ENSG00000101236 ENSMUSG00000048911 UniProt Q9Y225 Q8BGI1 RefSeq (mRNA) NM_001134337 NM_001134338 NM_007219 NM_001321749 NM_016502 NM_178607 RefSeq (protein) NP_001127809 NP_001127810 NP_001308678 NP_009150 NP_848722 Location (UCSC) Chr 20: 3.93 – 4.02 Mb Chr 2: 131.14 – 131.19 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ring finger protein 24 is a protein that in humans is encoded by the RNF24 gene. ^{[5] [6]}

RNF24 binds TRPC6 (603652) and other transient receptor potential cation channel (TRPC) family members and is involved in regulation of intracellular trafficking of TRPCs. ^[6] In addition, RNF24 contains similarity to the Drosophila goliath protein and thus may function as a transcription factor. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000101236 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000048911 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: ring finger protein 24".
6. Lussier MP, Lepage PK, Bousquet SM, Boulay G (May 2008). "RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC". Cell Calcium. 43 (5): 432–43. doi:10.1016/j.ceca.2007.07.009. PMID   17850865.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Zhang QH, Ye M, Wu XY, et al. (2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC   310934 . PMID   11042152.
• Deloukas P, Matthews LH, Ashurst J, et al. (2001). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID   11780052.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.