Roundabout homolog 2 is a protein that in humans is encoded by the ROBO2 gene. [5] [6]
Roundabout homolog 2 is a protein that in humans is encoded by the ROBO2 gene. [5] [6]
Netrin receptor DCC, also known as DCC, or colorectal cancer suppressor is a protein which in humans is encoded by the DCC gene. DCC has long been implicated in colorectal cancer and its previous name was Deleted in colorectal carcinoma. Netrin receptor DCC is a single transmembrane receptor.
Neuropilin 2 (NRP2) is a protein that in humans is encoded by the NRP2 gene.
Taste receptor type 2 member 3 is a protein that in humans is encoded by the TAS2R3 gene.
Taste receptor type 2 member 13 is a protein that in humans is encoded by the TAS2R13 gene.
Neuropilin-1 is a protein that in humans is encoded by the NRP1 gene. In humans, the neuropilin 1 gene is located at 10p11.22. This is one of two human neuropilins.
Slit homolog 2 protein is a protein that in humans is encoded by the SLIT2 gene.
Semaphorin-3A is a protein that in humans is encoded by the SEMA3A gene.
Nuclear factor of activated T-cells, cytoplasmic 4 is a protein that in humans is encoded by the NFATC4 gene.
Roundabout homolog 1 is a protein that in humans is encoded by the ROBO1 gene.
Netrin-1 is a protein that in humans is encoded by the NTN1 gene.
Plexin-B2 is a protein that in humans is encoded by the PLXNB2 gene.
Neogenin is a protein that in humans is encoded by the NEO1 gene.
Slit homolog 3 protein is a protein that in humans is encoded by the SLIT3 gene.
Plexin-A4 is a protein that in humans is encoded by the PLXNA4 gene.
The Roundabout (Robo) family of proteins are single-pass transmembrane receptors that are highly conserved across many branches of the animal kingdom, from C. elegans to humans. They were first discovered in Drosophila, through a mutant screen for genes involved in axon guidance. The Drosophila roundabout mutant was named after its phenotype, which resembled the circular traffic junctions. The Robo receptors are most well known for their role in the development of the nervous system, where they have been shown to respond to secreted Slit ligands. One well-studied example is the requirement for Slit-Robo signaling in regulation of axonal midline crossing. Slit-Robo signaling is also critical for many neurodevelopmental processes including formation of the olfactory tract, the optic nerve, and motor axon fasciculation. In addition, Slit-Robo signaling contributes to cell migration and the development of other tissues such as the lung, kidney, liver, muscle and breast. Mutations in Robo genes have been linked to multiple neurodevelopmental disorders in humans.
Slit is a family of secreted extracellular matrix proteins which play an important signalling role in the neural development of most bilaterians. While lower animal species, including insects and nematode worms, possess a single Slit gene, humans, mice and other vertebrates possess three Slit homologs: Slit1, Slit2 and Slit3. Human Slits have been shown to be involved in certain pathological conditions, such as cancer and inflammation.
Slit-Robo is the name of a cell signaling protein complex with many diverse functions including axon guidance and angiogenesis.
Ephrin A5 is a protein that in humans is encoded by the EFNA5 gene.
The growth cone is a highly dynamic structure of the developing neuron, changing directionality in response to different secreted and contact-dependent guidance cues; it navigates through the developing nervous system in search of its target. The migration of the growth cone is mediated through the interaction of numerous trophic and tropic factors; netrins, slits, ephrins and semaphorins are four well-studied tropic cues (Fig.1). The growth cone is capable of modifying its sensitivity to these guidance molecules as it migrates to its target; this sensitivity regulation is an important theme seen throughout development.
Alain Chédotal is a French researcher specialising in the development of neural circuits. He has been a member of the French Academy of sciences since 2017.
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