RPE (gene)

RPE
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3OVQ, 3OVR, 3OVP, 3QC3
Identifiers
Aliases	RPE , RPE2-1, ribulose-5-phosphate-3-epimerase
External IDs	OMIM: 180480 MGI: 1913896 HomoloGene: 12005 GeneCards: RPE
Gene location (Human)
Chr.	Chromosome 2 (human)
End	210,022,260 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	66,758,964 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; Achilles tendon; ; rectum; ; bone marrow cells; ; Brodmann area 23; ; endothelial cell; ; stromal cell of endometrium; ; monocyte; ; internal globus pallidus; ; germinal epithelium;
	Top expressed in
	saccule; ; seminal vesicula; ; brown adipose tissue; ; intercostal muscle; ; gastric mucosa; ; otic placode; ; mucous cell of stomach; ; secondary oocyte; ; duodenum; ; urothelium;
	More reference expression data
	n/a
Gene ontology
Molecular function	racemase and epimerase activity, acting on carbohydrates and derivatives ; ribulose-phosphate 3-epimerase activity ; catalytic activity ; isomerase activity ; protein homodimerization activity ; metal ion binding ; identical protein binding ;
Cellular component	cytosol ; extracellular exosome ;
Biological process	pentose catabolic process ; pentose-phosphate shunt ; metabolism ; pentose-phosphate shunt, non-oxidative branch ; cellular carbohydrate metabolic process ; carbohydrate metabolic process ;
	Sources:Amigo / QuickGO
Orthologs
	6120
	66646
	ENSG00000197713
	ENSMUSG00000026005
	Q96AT9
	Q8VEE0
NM_001278282 ; NM_001278283 ; NM_001278285 ; NM_001278286 ; NM_001278288 ;
	NM_001278289 ; NM_006916 ; NM_199229 ; NM_001318926 ; NM_001318927 ; NM_001318928 ; NM_001318929 ; NM_001318930 ; NM_001318931
	NM_025683 ; NM_001310642 ; NM_001310643 ; NM_001310644
NP_001265211 ; NP_001265212 ; NP_001265214 ; NP_001265215 ; NP_001265217 ;
	NP_001265218 ; NP_001305855 ; NP_001305856 ; NP_001305857 ; NP_001305858 ; NP_001305859 ; NP_001305860 ; NP_008847 ; NP_954699
	NP_001297571 ; NP_001297572 ; NP_001297573 ; NP_079959
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 14, 2023

Ribulose-phosphate 3-epimerase is an enzyme that in humans is encoded by the RPE gene.^[5]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000197713 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026005 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: RPE ribulose-5-phosphate-3-epimerase".

Boss GR, Pilz RB (1985). "Phosphoribosylpyrophosphate synthesis from glucose decreases during amino acid starvation of human lymphoblasts". J. Biol. Chem. 260 (10): 6054–9. doi: 10.1016/S0021-9258(18)88936-0 . PMID 2581946.
Miyazaki K, Yamanaka T, Ogasawara N (1989). "Interstitial deletion 2q32.1----q34 in a child with half normal activity of ribulose 5-phosphate 3-epimerase (RPE)". J. Med. Genet. 25 (12): 850–1. doi:10.1136/jmg.25.12.850. PMC 1051616 . PMID 3236368.
Dallapiccola B, Novelli G, Giannotti A (1988). "Deletion 2q31.3----2q33.3: gene dosage effect of ribulose 5-phosphate 3-epimerase". Hum. Genet. 79 (1): 92. doi:10.1007/BF00291721. PMID 3366467. S2CID 12134011.
Spencer N, Hopkinson DA (1980). "Biochemical genetics of the pentose phosphate cycle: human ribose 5-phosphate isomerase (RPI) and ribulose 5-phosphate 3-epimerase (RPE)". Ann. Hum. Genet. 43 (4): 335–42. doi:10.1111/j.1469-1809.1980.tb01567.x. PMID 7396409. S2CID 24547339.
Stanchi F, Bertocco E, Toppo S, et al. (2001). "Characterization of 16 novel human genes showing high similarity to yeast sequences". Yeast. 18 (1): 69–80. doi: 10.1002/1097-0061(200101)18:1<69::AID-YEA647>3.0.CO;2-H . PMID 11124703. S2CID 21397515.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147 . PMID 15231747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Krull M, Brosius J, Schmitz J (2005). "Alu-SINE exonization: en route to protein-coding function". Mol. Biol. Evol. 22 (8): 1702–11. doi: 10.1093/molbev/msi164 . PMID 15901843.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000197713 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026005 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: RPE ribulose-5-phosphate-3-epimerase".

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RPE (gene)

Related Research Articles

References

Further reading