RPL22L1

RPL22L1
Identifiers
Aliases	RPL22L1 , ribosomal protein L22 like 1
External IDs	HomoloGene: 134069 GeneCards: RPL22L1
Gene location (Human)
Chr.	Chromosome 3 (human)
End	170,870,208 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; appendix; ; gums; ; lymph node; ; spleen; ; skin of abdomen; ; bone marrow; ; islet of Langerhans; ; cavity of mouth; ; monocyte;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	structural constituent of ribosome ; RNA binding ;
Cellular component	cytosolic large ribosomal subunit ; ribosome ; intracellular anatomical structure ;
Biological process	cytoplasmic translation ; protein biosynthesis ;
	Sources:Amigo / QuickGO
Orthologs
	200916
	n/a
	ENSG00000163584
	n/a
	Q6P5R6
	n/a
	NM_001099645 ; NM_001320451
	n/a
	NP_001093115 ; NP_001307380
	n/a
	Wikidata
View/Edit Human

Last updated March 04, 2023

Ribosomal protein L22 like 1 (RPL22L1), or eL22L1, is a protein that in humans is encoded by the RPL22L1 gene. ^[3]

Function

eL22L1 is a ribosomal protein paralog of the eL22 protein of the 60S ribosomal subunit. This paralog is divergent from the normal copy, and is expressed when the normal copy is deleted from mice.^[4] This compensation implies a ribosome function similar to the normal copy, though eL22L1 has also been implicates in other extraribosomal roles including pre-mRNA splicing regulation in zebrafish.^[5]

Related Research Articles

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60S ribosomal protein L3 is a protein that in humans is encoded by the RPL3 gene.

60S ribosomal protein L7 is a protein that in humans is encoded by the RPL7 gene.

60S ribosomal protein L11 is a protein that in humans is encoded by the RPL11 gene.

28S ribosomal protein S12, mitochondrial is a protein that in humans is encoded by the MRPS12 gene.

60S ribosomal protein L31 is a protein that in humans is encoded by the RPL31 gene.

60S ribosomal protein L12 is a protein that in humans is encoded by the RPL12 gene.

60S ribosomal protein L22 is a protein that in humans is encoded by the RPL22 gene on Chromosome 1.

60S ribosomal protein L28 is a protein that in humans is encoded by the RPL28 gene.

60S ribosomal protein L32 is a protein that in humans is encoded by the RPL32 gene.

60S ribosomal protein L36 is a protein that in humans is encoded by the RPL36 gene.

40S ribosomal protein S20 is a protein that in humans is encoded by the RPS20 gene.

Fanconi anemia, complementation group I (FANCI) also known as KIAA1794, is a protein which in humans is encoded by the FANCI gene. Mutations in the FANCI gene are known to cause Fanconi anemia.

60S ribosomal protein L34 is a protein that in humans is encoded by the RPL34 gene.

39S ribosomal protein L39, mitochondrial is a protein that in humans is encoded by the MRPL39 gene.

60S ribosomal protein L17 is a protein that in humans is encoded by the RPL17 gene.

60S ribosomal protein L26 is a protein that in humans is encoded by the RPL26 gene.

28S ribosomal protein S21, mitochondrial is a protein that in humans is encoded by the MRPS21 gene.

60S ribosomal protein L27a is a protein that in humans is encoded by the RPL27A gene.

39S ribosomal protein L33, mitochondrial is a protein that in humans is encoded by the MRPL33 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000163584 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Ribosomal protein L22 like 1" . Retrieved 2019-12-03.
↑ O'Leary MN, Schreiber KH, Zhang Y, Duc AC, Rao S, Hale JS, et al. (2013-08-22). Copenhaver GP (ed.). "The ribosomal protein Rpl22 controls ribosome composition by directly repressing expression of its own paralog, Rpl22l1". PLOS Genetics. Public Library of Science (PLoS). 9 (8): e1003708. doi: 10.1371/journal.pgen.1003708 . PMC 3750023 . PMID 23990801.
↑ Zhang Y, O'Leary MN, Peri S, Wang M, Zha J, Melov S, et al. (January 2017). "Ribosomal Proteins Rpl22 and Rpl22l1 Control Morphogenesis by Regulating Pre-mRNA Splicing". Cell Reports. Elsevier BV. 18 (2): 545–556. doi: 10.1016/j.celrep.2016.12.034 . PMC 5234864 . PMID 28076796.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000163584 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: Ribosomal protein L22 like 1" . Retrieved 2019-12-03.

[OLeary_Schreiber_Zhang_Duc_p=e1003708-4] O'Leary MN, Schreiber KH, Zhang Y, Duc AC, Rao S, Hale JS, et al. (2013-08-22). Copenhaver GP (ed.). "The ribosomal protein Rpl22 controls ribosome composition by directly repressing expression of its own paralog, Rpl22l1". PLOS Genetics. Public Library of Science (PLoS). 9 (8): e1003708. doi: 10.1371/journal.pgen.1003708 . PMC 3750023 . PMID 23990801.

[Zhang_O’Leary_Peri_Wang_2017_pp._545–556-5] Zhang Y, O'Leary MN, Peri S, Wang M, Zha J, Melov S, et al. (January 2017). "Ribosomal Proteins Rpl22 and Rpl22l1 Control Morphogenesis by Regulating Pre-mRNA Splicing". Cell Reports. Elsevier BV. 18 (2): 545–556. doi: 10.1016/j.celrep.2016.12.034 . PMC 5234864 . PMID 28076796.

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RPL22L1

Contents

Function

See also

Related Research Articles

References