RRAS2

RRAS2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ERY
Identifiers
Aliases	RRAS2 , TC21, related RAS viral (r-ras) oncogene homolog 2, RAS related 2, NS12
External IDs	OMIM: 600098; MGI: 1914172; HomoloGene: 6945; GeneCards: RRAS2; OMA:RRAS2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p15.2 Start 14,277,922 bp [1] End 14,364,506 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 F1 Start 113,646,017 bp [2] End 113,717,016 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte Skeletal muscle tissue of rectus abdominis epithelium of colon kidney tubule biceps brachii Skeletal muscle tissue of biceps brachii thoracic diaphragm glutes mucosa of paranasal sinus germinal epithelium Top expressed in interventricular septum endothelial cell of lymphatic vessel decidua endocardial cushion medullary collecting duct gastrula renal corpuscle left lung lobe atrioventricular valve stroma of bone marrow More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding protein binding GTPase activity GDP binding Cellular component plasma membrane extracellular exosome intracellular anatomical structure endoplasmic reticulum membrane focal adhesion Biological process cellular process or phenomenon Ras protein signal transduction osteoblast differentiation regulation of neuron death signal transduction positive regulation of cell migration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22800 66922 Ensembl ENSG00000133818 ENSMUSG00000055723 UniProt P62070 P62071 RefSeq (mRNA) NM_012250 NM_001102669 NM_001177314 NM_001177315 NM_025846 RefSeq (protein) NP_001096139 NP_001170785 NP_001170786 NP_036382 NP_080122 Location (UCSC) Chr 11: 14.28 – 14.36 Mb Chr 7: 113.65 – 113.72 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ras-related protein R-Ras2 is a protein that in humans is encoded by the RRAS2 gene. ^{[5] [6] [7]}

Interactions

RRAS2 has been shown to interact with C-Raf. ^{[8] [9]}

References

1. GRCh38: Ensembl release 89: ENSG00000133818 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000055723 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Drivas GT, Shih A, Coutavas E, Rush MG, D'Eustachio P (May 1990). "Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line". Mol Cell Biol. 10 (4): 1793–8. doi:10.1128/mcb.10.4.1793. PMC   362288 . PMID   2108320.
6. Chan AM, Miki T, Meyers KA, Aaronson SA (September 1994). "A human oncogene of the RAS superfamily unmasked by expression cDNA cloning". Proc Natl Acad Sci U S A. 91 (16): 7558–62. Bibcode:1994PNAS...91.7558C. doi: 10.1073/pnas.91.16.7558 . PMC   44441 . PMID   8052619.
7. "Entrez Gene: RRAS2 related RAS viral (r-ras) oncogene homolog 2".
8. Li W, Han M, Guan K L (April 2000). "The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf". Genes Dev. 14 (8). UNITED STATES: 895–900. doi:10.1101/gad.14.8.895. ISSN   0890-9369. PMC   316541 . PMID   10783161.
9. Movilla N, Crespo P, Bustelo X R (October 1999). "Signal transduction elements of TC21, an oncogenic member of the R-Ras subfamily of GTP-binding proteins". Oncogene. 18 (43). ENGLAND: 5860–9. doi:10.1038/sj.onc.1202968. ISSN   0950-9232. PMID   10557073. S2CID   31576945.

Further reading

• Ehrhardt A, Ehrhardt GR, Guo X, Schrader JW (2002). "Ras and relatives--job sharing and networking keep an old family together". Exp. Hematol. 30 (10): 1089–106. doi: 10.1016/S0301-472X(02)00904-9 . PMID   12384139.
• Rosário M, Paterson HF, Marshall CJ (1999). "Activation of the Raf/MAP kinase cascade by the Ras-related protein TC21 is required for the TC21-mediated transformation of NIH 3T3 cells". EMBO J. 18 (5): 1270–9. doi:10.1093/emboj/18.5.1270. PMC   1171217 . PMID   10064593.
• Linnemann T, Geyer M, Jaitner BK, et al. (1999). "Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily". J. Biol. Chem. 274 (19): 13556–62. doi: 10.1074/jbc.274.19.13556 . PMID   10224125.
• Ehrhardt GR, Leslie KB, Lee F, et al. (1999). "M-Ras, a widely expressed 29-kD homologue of p21 Ras: expression of a constitutively active mutant results in factor-independent growth of an interleukin-3-dependent cell line". Blood. 94 (7): 2433–44. doi:10.1182/blood.V94.7.2433.419k31_2433_2444. PMID   10498616. S2CID   40024826.
• Movilla N, Crespo P, Bustelo XR (1999). "Signal transduction elements of TC21, an oncogenic member of the R-Ras subfamily of GTP-binding proteins". Oncogene. 18 (43): 5860–9. doi:10.1038/sj.onc.1202968. PMID   10557073. S2CID   31576945.
• Ohba Y, Mochizuki N, Yamashita S, et al. (2000). "Regulatory proteins of R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3". J. Biol. Chem. 275 (26): 20020–6. doi: 10.1074/jbc.M000981200 . PMID   10777492.
• Figueroa C, Taylor J, Vojtek AB (2001). "Prenylated Rab acceptor protein is a receptor for prenylated small GTPases". J. Biol. Chem. 276 (30): 28219–25. doi: 10.1074/jbc.M101763200 . PMID   11335720.
• Murphy GA, Graham SM, Morita S, et al. (2002). "Involvement of phosphatidylinositol 3-kinase, but not RalGDS, in TC21/R-Ras2-mediated transformation". J. Biol. Chem. 277 (12): 9966–75. doi: 10.1074/jbc.M109059200 . PMID   11788587.
• Rong R, He Q, Liu Y, et al. (2002). "TC21 mediates transformation and cell survival via activation of phosphatidylinositol 3-kinase/Akt and NF-kappaB signaling pathway". Oncogene. 21 (7): 1062–70. doi: 10.1038/sj.onc.1205154 . PMID   11850823. S2CID   21196767.
• Ortiz-Vega S, Khokhlatchev A, Nedwidek M, et al. (2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene. 21 (9): 1381–90. doi:10.1038/sj.onc.1205192. PMID   11857081. S2CID   240243.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Yuryev A, Wennogle LP (2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics. 81 (2): 112–25. doi:10.1016/S0888-7543(02)00008-3. PMID   12620389.
• Mitin NY, Ramocki MB, Zullo AJ, et al. (2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization". J. Biol. Chem. 279 (21): 22353–61. doi: 10.1074/jbc.M312867200 . PMID   15031288.
• Kho Y, Kim SC, Jiang C, et al. (2004). "A tagging-via-substrate technology for detection and proteomics of farnesylated proteins". Proc. Natl. Acad. Sci. U.S.A. 101 (34): 12479–84. Bibcode:2004PNAS..10112479K. doi: 10.1073/pnas.0403413101 . PMC   515085 . PMID   15308774.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC   515316 . PMID   15342556.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID   15761153. S2CID   39457788.