RRAS2

RRAS2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2ERY
Identifiers
Aliases	RRAS2 , TC21, related RAS viral (r-ras) oncogene homolog 2, RAS related 2, NS12
External IDs	OMIM: 600098 MGI: 1914172 HomoloGene: 6945 GeneCards: RRAS2
Gene location (Human)
Chr.	Chromosome 11 (human)
End	14,364,506 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	113,717,016 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; kidney tubule; ; biceps brachii; ; thoracic diaphragm; ; germinal epithelium; ; glomerulus; ; vastus lateralis muscle; ; metanephric glomerulus; ; placenta; ; hair follicle;
	Top expressed in
	interventricular septum; ; endocardial cushion; ; medullary collecting duct; ; renal corpuscle; ; left lung lobe; ; atrioventricular valve; ; secondary oocyte; ; primitive streak; ; right ventricle; ; myocardium of ventricle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding ; GTP binding ; protein binding ; GTPase activity ; GDP binding ;
Cellular component	plasma membrane ; extracellular exosome ; intracellular anatomical structure ; endoplasmic reticulum ; membrane ; focal adhesion ;
Biological process	cellular process ; Ras protein signal transduction ; osteoblast differentiation ; regulation of neuron death ; signal transduction ; positive regulation of cell migration ;
	Sources:Amigo / QuickGO
Orthologs
	22800
	66922
	ENSG00000133818
	ENSMUSG00000055723
	P62070
	P62071
	NM_012250 ; NM_001102669 ; NM_001177314 ; NM_001177315
	NM_025846
	NP_001096139 ; NP_001170785 ; NP_001170786 ; NP_036382
	NP_080122
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 25, 2023

Ras-related protein R-Ras2 is a protein that in humans is encoded by the RRAS2 gene.^[5]^[6]^[7]

Interactions

RRAS2 has been shown to interact with C-Raf.^[8]^[9]

Related Research Articles

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NUAK family SNF1-like kinase 1 also known as AMPK-related protein kinase 5 (ARK5) is an enzyme that in humans is encoded by the NUAK1 gene.

Rap1 GTPase-GDP dissociation stimulator 1 is an enzyme that in humans is encoded by the RAP1GDS1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000133818 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000055723 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Drivas GT, Shih A, Coutavas E, Rush MG, D'Eustachio P (May 1990). "Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line". Mol Cell Biol. 10 (4): 1793–8. doi:10.1128/mcb.10.4.1793. PMC 362288 . PMID 2108320.
↑ Chan AM, Miki T, Meyers KA, Aaronson SA (September 1994). "A human oncogene of the RAS superfamily unmasked by expression cDNA cloning". Proc Natl Acad Sci U S A. 91 (16): 7558–62. Bibcode:1994PNAS...91.7558C. doi: 10.1073/pnas.91.16.7558 . PMC 44441 . PMID 8052619.
↑ "Entrez Gene: RRAS2 related RAS viral (r-ras) oncogene homolog 2".
↑ Li W, Han M, Guan K L (April 2000). "The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf". Genes Dev. UNITED STATES. 14 (8): 895–900. doi:10.1101/gad.14.8.895. ISSN 0890-9369. PMC 316541 . PMID 10783161.
↑ Movilla N, Crespo P, Bustelo X R (October 1999). "Signal transduction elements of TC21, an oncogenic member of the R-Ras subfamily of GTP-binding proteins". Oncogene. ENGLAND. 18 (43): 5860–9. doi:10.1038/sj.onc.1202968. ISSN 0950-9232. PMID 10557073. S2CID 31576945.

Ehrhardt A, Ehrhardt GR, Guo X, Schrader JW (2002). "Ras and relatives--job sharing and networking keep an old family together". Exp. Hematol. 30 (10): 1089–106. doi: 10.1016/S0301-472X(02)00904-9 . PMID 12384139.
Rosário M, Paterson HF, Marshall CJ (1999). "Activation of the Raf/MAP kinase cascade by the Ras-related protein TC21 is required for the TC21-mediated transformation of NIH 3T3 cells". EMBO J. 18 (5): 1270–9. doi:10.1093/emboj/18.5.1270. PMC 1171217 . PMID 10064593.
Linnemann T, Geyer M, Jaitner BK, et al. (1999). "Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily". J. Biol. Chem. 274 (19): 13556–62. doi: 10.1074/jbc.274.19.13556 . PMID 10224125.
Ehrhardt GR, Leslie KB, Lee F, et al. (1999). "M-Ras, a widely expressed 29-kD homologue of p21 Ras: expression of a constitutively active mutant results in factor-independent growth of an interleukin-3-dependent cell line". Blood. 94 (7): 2433–44. doi:10.1182/blood.V94.7.2433.419k31_2433_2444. PMID 10498616. S2CID 40024826.
Movilla N, Crespo P, Bustelo XR (1999). "Signal transduction elements of TC21, an oncogenic member of the R-Ras subfamily of GTP-binding proteins". Oncogene. 18 (43): 5860–9. doi:10.1038/sj.onc.1202968. PMID 10557073. S2CID 31576945.
Ohba Y, Mochizuki N, Yamashita S, et al. (2000). "Regulatory proteins of R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3". J. Biol. Chem. 275 (26): 20020–6. doi: 10.1074/jbc.M000981200 . PMID 10777492.
Figueroa C, Taylor J, Vojtek AB (2001). "Prenylated Rab acceptor protein is a receptor for prenylated small GTPases". J. Biol. Chem. 276 (30): 28219–25. doi: 10.1074/jbc.M101763200 . PMID 11335720.
Murphy GA, Graham SM, Morita S, et al. (2002). "Involvement of phosphatidylinositol 3-kinase, but not RalGDS, in TC21/R-Ras2-mediated transformation". J. Biol. Chem. 277 (12): 9966–75. doi: 10.1074/jbc.M109059200 . PMID 11788587.
Rong R, He Q, Liu Y, et al. (2002). "TC21 mediates transformation and cell survival via activation of phosphatidylinositol 3-kinase/Akt and NF-kappaB signaling pathway". Oncogene. 21 (7): 1062–70. doi: 10.1038/sj.onc.1205154 . PMID 11850823. S2CID 21196767.
Ortiz-Vega S, Khokhlatchev A, Nedwidek M, et al. (2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene. 21 (9): 1381–90. doi:10.1038/sj.onc.1205192. PMID 11857081. S2CID 240243.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Yuryev A, Wennogle LP (2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics. 81 (2): 112–25. doi:10.1016/S0888-7543(02)00008-3. PMID 12620389.
Mitin NY, Ramocki MB, Zullo AJ, et al. (2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization". J. Biol. Chem. 279 (21): 22353–61. doi: 10.1074/jbc.M312867200 . PMID 15031288.
Kho Y, Kim SC, Jiang C, et al. (2004). "A tagging-via-substrate technology for detection and proteomics of farnesylated proteins". Proc. Natl. Acad. Sci. U.S.A. 101 (34): 12479–84. Bibcode:2004PNAS..10112479K. doi: 10.1073/pnas.0403413101 . PMC 515085 . PMID 15308774.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316 . PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000133818 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000055723 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2108320-5] Drivas GT, Shih A, Coutavas E, Rush MG, D'Eustachio P (May 1990). "Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line". Mol Cell Biol. 10 (4): 1793–8. doi:10.1128/mcb.10.4.1793. PMC 362288 . PMID 2108320.

[pmid8052619-6] Chan AM, Miki T, Meyers KA, Aaronson SA (September 1994). "A human oncogene of the RAS superfamily unmasked by expression cDNA cloning". Proc Natl Acad Sci U S A. 91 (16): 7558–62. Bibcode:1994PNAS...91.7558C. doi: 10.1073/pnas.91.16.7558 . PMC 44441 . PMID 8052619.

[entrez-7] "Entrez Gene: RRAS2 related RAS viral (r-ras) oncogene homolog 2".

[pmid10783161-8] Li W, Han M, Guan K L (April 2000). "The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf". Genes Dev. UNITED STATES. 14 (8): 895–900. doi:10.1101/gad.14.8.895. ISSN 0890-9369. PMC 316541 . PMID 10783161.

[pmid10557073-9] Movilla N, Crespo P, Bustelo X R (October 1999). "Signal transduction elements of TC21, an oncogenic member of the R-Ras subfamily of GTP-binding proteins". Oncogene. ENGLAND. 18 (43): 5860–9. doi:10.1038/sj.onc.1202968. ISSN 0950-9232. PMID 10557073. S2CID 31576945.

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RRAS2

Contents

Interactions

Related Research Articles

References

Further reading