RRBP1

RRBP1
Identifiers
Aliases	RRBP1 , ES/130, ES130, RRp, hES, ribosome binding protein 1, p180
External IDs	OMIM: 601418; HomoloGene: 136784; GeneCards: RRBP1; OMA:RRBP1 - orthologs
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20p12.1 Start 17,613,678 bp [1] End 17,682,295 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas parotid gland tendon of biceps brachii pylorus stromal cell of endometrium sural nerve right lobe of liver epithelium of colon mucosa of nose mucosa of transverse colon n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA binding signaling receptor activity Cellular component integral component of membrane integral component of endoplasmic reticulum membrane ribosome endoplasmic reticulum membrane endoplasmic reticulum membrane Biological process protein transport protein biosynthesis osteoblast differentiation transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6238 n/a Ensembl ENSG00000125844 n/a UniProt Q9P2E9 n/a RefSeq (mRNA) NM_004587 NM_001042576 NM_001365613 n/a RefSeq (protein) NP_001036041 NP_004578 NP_001352542 n/a Location (UCSC) Chr 20: 17.61 – 17.68 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Ribosome-binding protein 1, also referred to as p180, is a protein that in humans is encoded by the RRBP1 gene. ^{[3] [4]}

RRBP1 is a membrane-bound protein found in the endoplasmic reticulum (ER). It was originally identified as the ribosome receptor for the ER, ^[5] however several groups later demonstrated that this activity did not co-fractionate with RRBP1 ^{[6] [7]} but rather with Sec61 (i.e. the translocon). ^{[8] [9]} RRBP1 can enhance the association of certain mRNAs to the endoplasmic reticulum in a manner that does not require ribosome activity, likely by directly associating the mRNA's phosphate backbone. ^[10] In addition, RRBP1 may promote the association of polysomes with the translocon ^{[11] [12]} and play a role in ER morphology. ^[13] RRBP1 may also bind to microtubules. ^[14] Although the p180 isoform is the most abundant, it may exist in different forms due to removal of tandem repeats by partial intraexonic splicing. RRBP1 has been excluded as a candidate gene in the cause of Alagille syndrome. ^[4]

References

1. GRCh38: Ensembl release 89: ENSG00000125844 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Basson CT, MacRae CA, Schoenberg-Fejzo M, Morton CC, Spinner NB, Genin A, Krug E, Seidman JG, Seidman CE (Dec 1996). "Identification, characterization, and chromosomal localization of the human homolog (hES) of ES/130". Genomics. 35 (3): 628–31. doi: 10.1006/geno.1996.0413 . PMID   8812507.
4. "Entrez Gene: RRBP1 ribosome binding protein 1 homolog 180kDa (dog)".
5. Savitz, Adam J.; Meyer, David I. (1990). "Identification of a ribosome receptor in the rough endoplasmic reticulum". Nature. 346 (6284): 540–544. Bibcode:1990Natur.346..540S. doi:10.1038/346540a0. ISSN   0028-0836. PMID   2165568. S2CID   4353593.
6. Nunnari, Jodi M.; Zimmerman, Deborah L.; Ogg, Stephen C.; Walter, Peter (1991). "Characterization of the rough endoplasmic reticulum ribosome-binding activity". Nature. 352 (6336): 638–640. Bibcode:1991Natur.352..638N. doi:10.1038/352638a0. ISSN   0028-0836. PMID   1650916. S2CID   4364699.
7. Collins, PG; Gilmore, R L (1991). "Ribosome binding to the endoplasmic reticulum: a 180-kD protein identified by crosslinking to membrane-bound ribosomes is not required for ribosome binding activity". Journal of Cell Biology. 114 (4): 639–49. CiteSeerX   10.1.1.282.646 . doi:10.1083/jcb.114.4.639. PMC   2289890 . PMID   1869584.
8. Görlich, Dirk; Prehn, Siegfried; Hartmann, Enno; Kalies, Kai-Uwe; Rapoport, Tom A. (1992). "A mammalian homolog of SEC61p and SECYp is associated with ribosomes and nascent polypeptides during translocation". Cell. 71 (3): 489–503. doi:10.1016/0092-8674(92)90517-G. ISSN   0092-8674. PMID   1423609. S2CID   19078317.
9. Gorlich, D (1993). "Protein translocation into proteoliposomes reconstituted from purified components of the endoplasmic reticulum membrane" (PDF). Cell. 75 (4): 615–630. doi: 10.1016/0092-8674(93)90483-7 . ISSN   0092-8674. PMID   8242738. S2CID   5476342.
10. Cui, Xianying A.; Zhang, Hui; Palazzo, Alexander F. (2012). "p180 Promotes the Ribosome-Independent Localization of a Subset of mRNA to the Endoplasmic Reticulum". PLOS Biology. 10 (5) e1001336. doi: 10.1371/journal.pbio.1001336 . ISSN   1545-7885. PMC   3362647 . PMID   22679391.
11. Dejgaard, Kurt; Theberge, Jean-Francois; Heath-Engel, Hannah; Chevet, Eric; Tremblay, Michel L.; Thomas, David Y. (2010). "Organization of the Sec61 Translocon, Studied by High Resolution Native Electrophoresis". Journal of Proteome Research. 9 (4): 1763–1771. doi:10.1021/pr900900x. ISSN   1535-3893. PMID   20112977.
12. Ueno, T.; Kaneko, K.; Sata, T.; Hattori, S.; Ogawa-Goto, K. (2011). "Regulation of polysome assembly on the endoplasmic reticulum by a coiled-coil protein, p180". Nucleic Acids Research. 40 (7): 3006–3017. doi:10.1093/nar/gkr1197. ISSN   0305-1048. PMC   3326322 . PMID   22156060.
13. Shibata, Yoko; Shemesh, Tom; Prinz, William A.; Palazzo, Alexander F.; Kozlov, Michael M.; Rapoport, Tom A. (2010). "Mechanisms Determining the Morphology of the Peripheral ER". Cell. 143 (5): 774–788. doi:10.1016/j.cell.2010.11.007. ISSN   0092-8674. PMC   3008339 . PMID   21111237.
14. Ogawa-Goto K, Tanaka K, Ueno T, et al. (2007). "p180 Is Involved in the Interaction between the Endoplasmic Reticulum and Microtubules through a Novel Microtubule-binding and Bundling Domain". Mol. Biol. Cell. 18 (10): 3741–51. doi:10.1091/mbc.E06-12-1125. PMC   1995732 . PMID   17634287.

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi: 10.1093/dnares/9.3.99 . PMID   12168954.
• Savitz AJ, Meyer DI (1990). "Identification of a ribosome receptor in the rough endoplasmic reticulum". Nature. 346 (6284): 540–4. Bibcode:1990Natur.346..540S. doi:10.1038/346540a0. PMID   2165568. S2CID   4353593.
• Langley R, Leung E, Morris C, et al. (1998). "Identification of multiple forms of 180-kDa ribosome receptor in human cells". DNA Cell Biol. 17 (5): 449–60. doi:10.1089/dna.1998.17.449. PMID   9628588.
• Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi: 10.1093/dnares/7.1.65 . PMID   10718198.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID   11780052.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Diefenbach RJ, Diefenbach E, Douglas MW, Cunningham AL (2004). "The ribosome receptor, p180, interacts with kinesin heavy chain, KIF5B". Biochem. Biophys. Res. Commun. 319 (3): 987–92. doi:10.1016/j.bbrc.2004.05.069. PMID   15184079.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC   442148 . PMID   15231748.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.