RRP1

RRP1
Identifiers
Aliases	RRP1 , D21S2056E, NNP-1, NOP52, RRP1A, ribosomal RNA processing 1
External IDs	OMIM: 610653; MGI: 1203500; HomoloGene: 90906; GeneCards: RRP1; OMA:RRP1 - orthologs
Gene location (Human) Chr. Chromosome 21 (human) [1] Band 21q22.3 Start 43,789,513 bp [1] End 43,805,293 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10 C1|10 39.72 cM Start 78,236,218 bp [2] End 78,248,877 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii gingival epithelium skin of leg buccal mucosa cell skin of abdomen gastrocnemius muscle cerebellar vermis sural nerve prefrontal cortex ganglionic eminence Top expressed in dentate gyrus of hippocampal formation granule cell neural layer of retina superior frontal gyrus saccule primary visual cortex tail of embryo otic vesicle cerebellar cortex otic placode supraoptic nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA binding protein binding Cellular component nucleus nucleolus preribosome, small subunit precursor preribosome, large subunit precursor Biological process rRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8568 18114 Ensembl ENSG00000160214 ENSMUSG00000061032 UniProt P56182 P56183 RefSeq (mRNA) NM_003683 NM_010925 RefSeq (protein) NP_003674 NP_035055 Location (UCSC) Chr 21: 43.79 – 43.81 Mb Chr 10: 78.24 – 78.25 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ribosomal RNA processing protein 1 homolog A is a protein that in humans is encoded by the RRP1 gene. ^{[5] [6] [7]}

The protein encoded by this gene is the putative homolog of the yeast ribosomal RNA processing protein RRP1. The encoded protein is involved in the late stages of nucleologenesis at the end of mitosis, and may be required for the generation of 28S rRNA. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000160214 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000061032 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML (Jun 2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi: 10.1038/35012518 . PMID   10830953.
6. Savino TM, Bastos R, Jansen E, Hernandez-Verdun D (Aug 1999). "The nucleolar antigen Nop52, the human homologue of the yeast ribosomal RNA processing RRP1, is recruited at late stages of nucleologenesis". J Cell Sci. 112. ( Pt 12) (12): 1889–900. doi:10.1242/jcs.112.12.1889. PMID   10341208.
7. "Entrez Gene: D21S2056E DNA segment on chromosome 21 (unique) 2056 expressed sequence".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Jansen E, Meulemans SM, Orlans IC, Van de Ven WJ (1997). "The NNP-1 gene (D21S2056E), which encodes a novel nuclear protein, maps in close proximity to the cystatin B gene within the EPM1 and APECED critical region on 21q22.3". Genomics. 42 (2): 336–41. doi:10.1006/geno.1997.4755. PMID   9192856.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi: 10.1016/S0960-9822(01)00650-9 . PMID   11790298. S2CID   14132033.
• Behrends U, Jandl T, Golbeck A, et al. (2002). "Novel products of the HUD, HUC, NNP-1 and alpha-internexin genes identified by autologous antibody screening of a pediatric neuroblastoma library". Int. J. Cancer. 100 (6): 669–77. doi: 10.1002/ijc.10550 . PMID   12209604. S2CID   35369661.
• Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC   133617 . PMID   12429849.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Hu YH, Warnatz HJ, Vanhecke D, et al. (2006). "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins". BMC Genomics. 7: 155. doi: 10.1186/1471-2164-7-155 . PMC   1526728 . PMID   16780588.