RRP12

RRP12
Identifiers
Aliases	RRP12 , KIAA0690, ribosomal RNA processing 12 homolog
External IDs	OMIM: 617723 MGI: 2147437 HomoloGene: 22370 GeneCards: RRP12
Gene location (Human)
Chr.	Chromosome 10 (human)
End	97,426,076 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	41,884,612 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; monocyte; ; bone marrow cells; ; anterior pituitary; ; blood; ; body of pancreas; ; stromal cell of endometrium; ; skin of abdomen; ; left ventricle; ; right uterine tube;
	Top expressed in
	otic placode; ; saccule; ; spermatid; ; primitive streak; ; seminiferous tubule; ; spermatocyte; ; yolk sac; ; ankle joint; ; quadriceps femoris muscle; ; temporal muscle;
	More reference expression data
	; ;
	More reference expression data
Orthologs
	23223
	107094
	ENSG00000052749
	ENSMUSG00000035049
	Q5JTH9
	Q6P5B0
	NM_001145114 ; NM_001284337 ; NM_015179
	NM_199447
	NP_001138586 ; NP_001271266 ; NP_055994
	NP_955518
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated April 12, 2024

RRP12-like protein is a protein that in humans is encoded by the RRP12 gene.^[5]^[6] It is currently thought to be involved in ribosome assembly of the precursor particles of both subunits in eukaryotes and was identified as a RNA binding protein.^[7]^[8]

Related Research Articles

40S ribosomal protein S3 is a protein that in humans is encoded by the RPS3 gene.

Eukaryotic translation initiation factor 6 (EIF6), also known as Integrin beta 4 binding protein (ITGB4BP), is a human gene.

60S ribosomal protein L3 is a protein that in humans is encoded by the RPL3 gene.

U2 small nuclear ribonucleoprotein A' is a protein that in humans is encoded by the SNRPA1 gene.

Cell division cycle 23 homolog , also known as CDC23, is a protein that, in humans, is encoded by the CDC23 gene.

RNA-binding protein 14 is a protein that in humans is encoded by the RBM14 gene.

Ribosome biogenesis protein BOP1 is a protein that in humans is encoded by the BOP1 gene. It is a WD40 repeat-containing nucleolar protein involved in rRNA processing, thereby controlling the cell cycle. It is required for the maturation of the 25S and 5.8S ribosomal RNAs. It may serve as an essential factor in ribosome formation that coordinates processing of the spacer regions in pre-rRNA.

60S ribosomal protein L31 is a protein that in humans is encoded by the RPL31 gene.

60S ribosomal protein L12 is a protein that in humans is encoded by the RPL12 gene.

60S ribosomal protein L22 is a protein that in humans is encoded by the RPL22 gene on Chromosome 1.

Ribosomal L1 domain-containing protein 1 is a protein that in humans is encoded by the RSL1D1 gene.

Small subunit processome component 20 homolog is a protein that in humans is encoded by the UTP20 gene.

60S ribosomal protein L18 is a protein that in humans is encoded by the RPL18 gene.

Ribosomal RNA processing protein 1 homolog B is a protein encoded by RRP1B gene which is located on Chromosome 21.

AT-rich interactive domain-containing protein 4B is a protein that in humans is encoded by the ARID4B gene.

Fanconi anemia, complementation group I (FANCI) also known as KIAA1794, is a protein which in humans is encoded by the FANCI gene. Mutations in the FANCI gene are known to cause Fanconi anemia.

60S ribosomal protein L13 is a protein that in humans is encoded by the RPL13 gene.

Gem-associated protein 5 is a protein that in humans is encoded by the GEMIN5 gene.

60S ribosomal protein L26 is a protein that in humans is encoded by the RPL26 gene.

DNA polymerase alpha subunit 2 is an enzyme that in humans is encoded by the POLA2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000052749 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035049 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (June 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (3): 169–76. doi: 10.1093/dnares/5.3.169 . PMID 9734811.
↑ "Entrez Gene: RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)".
↑ Oeffinger M, Dlakic M, Tollervey D (January 2004). "A pre-ribosome-associated HEAT-repeat protein is required for export of both ribosomal subunits". Genes & Development. 18 (2): 196–209. doi:10.1101/gad.285604. PMC 324425 . PMID 14729571.
↑ Moriggi G, Nieto B, Dosil M (December 2014). "Rrp12 and the Exportin Crm1 participate in late assembly events in the nucleolus during 40S ribosomal subunit biogenesis". PLOS Genetics. 10 (12): e1004836. doi: 10.1371/journal.pgen.1004836 . PMC 4256259 . PMID 25474739.

Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (January 2002). "Directed proteomic analysis of the human nucleolus". Current Biology. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi: 10.1016/S0960-9822(01)00650-9 . PMID 11790298.
Nakayama M, Kikuno R, Ohara O (November 2002). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Research. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542 . PMID 12421765.
Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ (November 2002). "Functional proteomic analysis of human nucleolus". Molecular Biology of the Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617 . PMID 12429849.
Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (February 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC 514446 . PMID 15302935.
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (January 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (April 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi: 10.1073/pnas.0507066103 . PMC 1459365 . PMID 16565220.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000052749 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035049 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9734811-5] Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (June 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (3): 169–76. doi: 10.1093/dnares/5.3.169 . PMID 9734811.

[entrez-6] "Entrez Gene: RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)".

[7] Oeffinger M, Dlakic M, Tollervey D (January 2004). "A pre-ribosome-associated HEAT-repeat protein is required for export of both ribosomal subunits". Genes & Development. 18 (2): 196–209. doi:10.1101/gad.285604. PMC 324425 . PMID 14729571.

[8] Moriggi G, Nieto B, Dosil M (December 2014). "Rrp12 and the Exportin Crm1 participate in late assembly events in the nucleolus during 40S ribosomal subunit biogenesis". PLOS Genetics. 10 (12): e1004836. doi: 10.1371/journal.pgen.1004836 . PMC 4256259 . PMID 25474739.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

RRP12

Related Research Articles

References

Further reading