RTL3

RTL3
Identifiers
Aliases	RTL3 , Mar3, Mart3, ZHC5, ZCCHC5, zinc finger CCHC-type containing 5, SIRH9, retrotransposon Gag like 3
External IDs	MGI: 2685221 HomoloGene: 19397 GeneCards: RTL3
Gene location (Human)
Chr.	X chromosome (human)
End	78,659,328 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	105,884,250 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; right coronary artery; ; ascending aorta; ; tibia; ; Achilles tendon; ; smooth muscle tissue; ; popliteal artery; ; left coronary artery; ; synovial membrane; ; saphenous vein;
	Top expressed in
	dermis; ; condyle; ; internal carotid artery; ; external carotid artery; ; atrioventricular valve; ; fossa; ; belly cord; ; endocardial cushion; ; esophagus; ; calvaria;
	More reference expression data
	n/a
Orthologs
	203430
	213436
	ENSG00000179300
	ENSMUSG00000047686
	Q8N8U3
	Q6P1Y1
	NM_152694
	NM_199468
	NP_689907
	NP_955762
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 10, 2023

Retrotransposon Gag like 3 is a protein that in humans is encoded by the RTL3 gene. ^[5]

Function

This gene is a member of a family of gag-related retrotransposon genes. These genes appear to have lost the ability to retrotranspose; however, their open reading frames have remained intact, which may indicate that these genes have acquired new functions in the cell. Retrotransposon gag-like-3 (RTL3/ZCCHC5/MART3) is one of eleven Sushi-like neogenes identified in the human genome7 RTL3 encodes a 53 kDa protein with a nucleic acid-binding domain (CX2CX4HX4C), gag-like region within the open reading frame and an ssDNA/RNA-binding homeobox-associated leucine zipper motif.^[6] It has been reported that RTL3 and SOX-9 co-regulate the expression of COL2A1 in chondrocytes.^[6]

Related Research Articles

<span class="mw-page-title-main">Collagen, type II, alpha 1</span>

Collagen, type II, alpha 1 , also known as COL2A1, is a human gene that provides instructions for the production of the pro-alpha1(II) chain of type II collagen.

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Class E basic helix-loop-helix protein 40 is a protein that in humans is encoded by the BHLHE40 gene.

Zinc finger protein 281 is a protein that in humans is encoded by the ZNF281 gene.

Homeobox protein Hox-A3 is a protein that in humans is encoded by the HOXA3 gene.

Fos-related antigen 2 (FRA2) is a protein that in humans is encoded by the FOSL2 gene.

ETS-related transcription factor Elf-4 is a protein that in humans is encoded by the ELF4 gene.

Transcription factor HES-5 is a protein that in humans is encoded by the HES5 gene.

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Nuclear factor, interleukin 3 regulated, also known as NFIL3 or E4BP4 is a protein which in humans is encoded by the NFIL3 gene.

Zinc finger and BTB domain-containing protein 7B is a protein that in humans is encoded by the ZBTB7B gene. ZFP67 is an early growth response gene that encodes a zinc finger-containing transcription factor that binds to the promoter regions of type I collagen genes and has a role in development.[supplied by OMIM]

Transcription factor HIVEP3 is a protein that in humans is encoded by the HIVEP3 gene.

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LTR retrotransposons are class I transposable element characterized by the presence of long terminal repeats (LTRs) directly flanking an internal coding region. As retrotransposons, they mobilize through reverse transcription of their mRNA and integration of the newly created cDNA into another location. Their mechanism of retrotransposition is shared with retroviruses, with the difference that most LTR-retrotransposons do not form infectious particles that leave the cells and therefore only replicate inside their genome of origin. Those that do (occasionally) form virus-like particles are classified under Ortervirales.

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Retrotransposon Gag Like 6 is a protein encoded by the RTL6 gene in humans. RTL6 is a member of the Mart family of genes, which are related to Sushi-like retrotransposons and were derived from fish and amphibians. The RTL6 protein is localized to the nucleus and has a predicted leucine zipper motif that is known to bind nucleic acids in similar proteins, such as LDOC1.

Density regulated re-initiation and release factor (DENR) is a protein that in humans is encoded by the DENR gene.

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000179300 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000047686 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Retrotransposon Gag like 3" . Retrieved 2017-09-18.
1 2 Ball HC, Ansari MY, Ahmad N, Novak K, Haqqi TM (November 2021). "A retrotransposon gag-like-3 gene RTL3 and SOX-9 co-regulate the expression of COL2A1 in chondrocytes". Connective Tissue Research. 62 (6): 615–628. doi:10.1080/03008207.2020.1828380. PMC 8404968 . PMID 33043724.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000179300 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000047686 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Retrotransposon Gag like 3" . Retrieved 2017-09-18.

[Ball_2021-6] 1 2 Ball HC, Ansari MY, Ahmad N, Novak K, Haqqi TM (November 2021). "A retrotransposon gag-like-3 gene RTL3 and SOX-9 co-regulate the expression of COL2A1 in chondrocytes". Connective Tissue Research. 62 (6): 615–628. doi:10.1080/03008207.2020.1828380. PMC 8404968 . PMID 33043724.

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