RWDD3

RWDD3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EBK, 4Y1L
Identifiers
Aliases	RWDD3 , RSUME, RWD domain containing 3
External IDs	OMIM: 615875; MGI: 1920420; HomoloGene: 22899; GeneCards: RWDD3; OMA:RWDD3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p21.3 Start 95,234,210 bp [1] End 95,247,225 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 G1 Start 120,949,047 bp [2] End 120,965,344 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endometrium body of pancreas Achilles tendon right lobe of liver nucleus accumbens amygdala putamen olfactory zone of nasal mucosa caudate nucleus corpus callosum Top expressed in medial ganglionic eminence lumbar subsegment of spinal cord supraoptic nucleus arcuate nucleus ventromedial nucleus dentate gyrus paraventricular nucleus of hypothalamus dorsomedial hypothalamic nucleus median eminence embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm nucleus Biological process negative regulation of NF-kappaB transcription factor activity positive regulation of protein sumoylation positive regulation of hypoxia-inducible factor-1alpha signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25950 66568 Ensembl ENSG00000122481 ENSMUSG00000028133 UniProt Q9Y3V2 Q8VIL2 RefSeq (mRNA) NM_001128142 NM_001199682 NM_001278247 NM_001278248 NM_015485 NM_025637 NM_028456 RefSeq (protein) NP_001121614 NP_001186611 NP_001265176 NP_001265177 NP_056300 n/a Location (UCSC) Chr 1: 95.23 – 95.25 Mb Chr 3: 120.95 – 120.97 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

RWD domain-containing protein 3 is a protein that in humans is encoded by the RWDD3 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000122481 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028133 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
6. "Entrez Gene: RWDD3 RWD domain containing 3".

Further reading

• Carbia-Nagashima A, Gerez J, Perez-Castro C, et al. (2008). "RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia". Cell. 131 (2): 309–23. doi:10.1016/j.cell.2007.07.044. hdl: 20.500.12110/paper_00928674_v131_n2_p309_CarbiaNagashima . PMID   17956732. S2CID   12486303.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID   7566098.