Medicinal or pharmaceutical chemistry is a scientific discipline at the intersection of chemistry and pharmacy involved with designing and developing pharmaceutical drugs. Medicinal chemistry involves the identification, synthesis and development of new chemical entities suitable for therapeutic use. It also includes the study of existing drugs, their biological properties, and their quantitative structure-activity relationships (QSAR).
Heptazine, or tri-s-triazine or cyamelurine, is a chemical compound with formula C
6N
7H
3, that consist of a planar triangular core group or three fused triazine rings, with three hydrogen atoms at the corners. It is a yellow, weakly fluorescent solid with melting point over 300 °C. It is soluble in organic solvents such as acetonitrile, but is decomposed by water in the presence of light.
Carolyn Ruth Bertozzi is an American chemist and Nobel laureate, known for her wide-ranging work spanning both chemistry and biology. She coined the term "bioorthogonal chemistry" for chemical reactions compatible with living systems. Her recent efforts include synthesis of chemical tools to study cell surface sugars called glycans and how they affect diseases such as cancer, inflammation, and viral infections like COVID-19. At Stanford University, she holds the Anne T. and Robert M. Bass Professorship in the School of Humanities and Sciences. Bertozzi is also an Investigator at the Howard Hughes Medical Institute (HHMI) and is the former Director of the Molecular Foundry, a nanoscience research center at Lawrence Berkeley National Laboratory.
François Diederich was a Luxembourgian chemist specializing in organic chemistry.
Peter B. Dervan is the Bren Professor of Chemistry at the California Institute of Technology. The primary focus of his research is the development and study of small organic molecules that can sequence-specifically recognize DNA, a field in which he is an internationally recognized authority. The most important of these small molecules are pyrrole–imidazole polyamides. Dervan is credited with influencing "the course of research in organic chemistry through his studies at the interface of chemistry and biology" as a result of his work on "the chemical principles involved in sequence-specific recognition of double helical DNA". He is the recipient of many awards, including the National Medal of Science (2006).
Dale Lester Boger is an American medicinal and organic chemist and former chair of the Department of Chemistry at The Scripps Research Institute in La Jolla, CA.
Robert George Bergman is an American chemist. He is Professor of the Graduate School and Gerald E. K. Branch Distinguished Professor Emeritus at the University of California, Berkeley.
Narayan S. Hosmane is an Indian-born cancer research scientist who made the featured article in NRI Achievers magazine and is currently distinguished research professor of Chemistry and Biochemistry. He received the Humboldt Research Award for senior scientists twice. This award is presented annually to scientists worldwide as a tribute to their lifelong accomplishments by Alexander von Humboldt Foundation, Bonn, Germany.
William E. Bentley is the Robert E. Fischell Distinguished Professor of Engineering, founding Director of the Fischell Institute for Biomedical Devices, and Director of the Maryland Technology Enterprise Institute located in the A. James Clark School of Engineering at the University of Maryland. He was previously the Chair of the Fischell Department of Bioengineering, where he assisted in establishing the department and provided leadership that led to its nationally ranked status.
Catherine Clarke Fenselau is an American scientist who was the first trained mass spectrometrist on the faculty of an American medical school; she joined Johns Hopkins School of Medicine in 1968. She specializes in biomedical applications of mass spectrometry. She has been recognized as an outstanding scientist in the field of bioanalytical chemistry because of her work using mass spectrometry to study biomolecules.
Robert Vince is an American scientist known for his contributions to the research in the area of drug design. He is currently the director and professor at the Center for Drug Design at the Academic Health Center for the University of Minnesota.
Santanu Bhattacharya is an Indian bioorganic chemist and a professor at the Indian Institute of Science. He is known for his studies of unnatural amino acids, oligopeptides and biologically active natural products and is an elected fellow of the Indian National Science Academy The World Academy of Sciences and the Indian Academy of Sciences The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards, in 2003, for his contributions to chemical sciences. He is also a recipient of the National Bioscience Award for Career Development of the Department of Biotechnology (2002) and the TWAS Prize (2010).
Paul Gassman was an American chemist. He is best known for his research in the field of organic chemistry and his service as president of the American Chemical Society and is listed among notable alumni by the Cornell University Graduate School.
Michal Hocek is a Czech chemist. He is a group leader at the Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences and a professor of organic chemistry at Charles University in Prague. He specializes in the chemistry and chemical biology of nucleosides, nucleotides, and nucleic acids.
Donna M. Huryn is an American medicinal and organic chemist. She received her B.A. (Chemistry) from Cornell University, and Ph.D. in Organic Chemistry from the University of Pennsylvania. She is on the faculty at the University of Pittsburgh’s School of Pharmacy, holds an adjunct appointment in the Department of Chemistry at the University of Pennsylvania, is the principal investigator of the University of Pittsburgh Chemical Diversity Center, and was a visiting fellow in the summer of 2017 at the University of Bologna. She is a fellow of the American Chemical Society, recipient of the ACS Philadelphia Local Section Award, has held a number of elected positions within the American Chemical Society at both the local and national levels, and is 2015 Chair of the Division of Organic Chemistry. She is associate editor of ACS Medicinal Chemistry Letters. She in also an editor of the journal Organic Reactions and co-authored the textbook Medicinal Chemistry and the article "Medicinal Chemistry: Where Are All the Women?" which appeared in the ACS Medicinal Chemistry Letters Journal. Huryn’s research focuses on the design and synthesis of small molecules probes and drugs to treat cancer, neurodegenerative and infectious diseases.
Katherine Seley-Radtke is an American medicinal chemist who specializes in the discovery and design of novel nucleoside or nucleotide based enzyme inhibitors that may be used to treat infections or cancer. She has authored over 90 peer-reviewed publications,is an inventor of five issued US patents, and is a Professor in the Department of Chemistry & Biochemistry at the University of Maryland, Baltimore County. Her international impact includes scientific collaborations, policy advising and diplomatic appointments in biosecurity efforts.
Dawn N. Ward, Ph.D. is a synthetic organic chemist and associate professor in chemistry at Stevenson University.
Jonathan Baell is an Australian medicinal chemist. He is a research professor in medicinal chemistry at the Monash Institute of Pharmaceutical Sciences (MIPS), the Director of the Australian Translational Medicinal Chemistry Facility and a Chief Investigator at the ARC Centre for Fragment-Based Design. He is also the President of the International Chemical Biology Society. His research focuses on the early stages of drug discovery, including high-throughput screening (HTS) library design, hit-to-lead and lead optimization for the treatment of a variety of diseases, such as malaria and neglected diseases.
Fred Wudl is an American materials scientist, academic researcher. He is a Professor Emeritus in the Department of Materials Engineering at the University of California, Santa Barbara.
David W. Wood is an American chemical engineer who is Professor of Chemical and Biomolecular Engineering at Ohio State University. Wood is also associated with the Department of Chemistry and Biochemistry and Molecular Biophysics Training Program.
