Rana P Singh

Rana P. Singh
Prof Rana Pratap Singh
Nationality	Indian
Alma mater	Jawaharlal Nehru University Ewing Christian College
Known for	Cancer Research
Spouse	Aruna Singh
Children	Ayushi
Scientific career
Institutions	Jawaharlal Nehru University Colorado University Central University of Gujarat Gautam Buddha University
Doctoral advisor	Prof A. Ramesha Rao
Website	rpscancerlab.com

Prof. Rana P Singh is an Indian cancer scientist ^[1] and Professor at the School of Life Sciences, Jawaharlal Nehru University (JNU), New Delhi, India. He is the Vice Chancellor of Gautam Buddha University, Greater Noida serving from February 2025 onwards. ^[2]

Singh is an academic administrator ^[3] who has established new departments, schools, and research centres in India. ^{[4] [5]}

His research includes stem cell biology, spheroids/ organoids, DNA repair mechanisms, and the effects of microgravity on radiobiology. ^[6] Singh's work examines cell signalling and the interactions that govern cellular behaviour and cancer progression, he contributes to the understanding of cancer and its treatment. ^[7] He has published over 194 research papers in scientific journals such as Nature , ^{[8] [9]} Oxford Academic , ^[10] Harvard Catalyst, ^[11] and the American Association for Cancer Research Journal. ^[12]

Early life and education

Singh completed his Ph.D. in life sciences with a specialization in cancer biology from Jawaharlal Nehru University, New Delhi, India, in 2000. Prior to this, he earned his M.Sc. in life sciences from Jawaharlal Nehru University. He obtained his B.Sc. in zoology, botany, and chemistry from Ewing Christian College, University of Allahabad, Uttar Pradesh, India. ^[13]

He worked at the University of Colorado as a research scholar and later as an assistant professor. ^[14]

Administrative positions

Singh founded the Special Centre for Systems Medicine ^[15] at Jawaharlal Nehru University (JNU) and has been chairperson of the centre since 2021. ^[16] This centre integrates scientific disciplines to improve healthcare, merging systems biology, computational biology, high-throughput data analysis, metabolomics, transcriptomics, regulomics, phenomics, and pharmacogenomics, along with biobanking, data analytics, and animal studies to develop diagnostic and prognostic technologies. Singh's establishment of this centre aligns with promoting interdisciplinary approaches within medical science at JNU as per National Education Policy 2020. ^[17]

He established the School of Life Sciences and its research facilities as its founding dean at the Central University of Gujarat from 2010 to 2012 ^[18] .

Singh served as rector ^[19] (pro-vice chancellor) of JNU from May 2017 to 2022 ^[20] and has been the president of the Institutional Innovation Council ^[21] at JNU since 2019. ^[22] His contributions to the university also include serving as Dean of Students, ^[23] court member, and executive council member. Prior to his tenure at JNU, he held positions at the Central University of Gujarat, including dean of students' welfare, ^[24] Dean of the School of Life Sciences, Dean of the School of Environmental Sciences, Provost, and chairman of the admission committee. ^[25]

Academic career

Singh's academic career in cancer biology has included positions at multiple institutions. Since 2012, he has been a professor of cancer biology at the School of Life Sciences, Jawaharlal Nehru University (JNU), New Delhi, India. From 2012 to 2016, he was an adjunct professor at the School of Life Sciences, Central University of Gujarat, Gandhinagar, where he previously served as a professor from 2010 to 2012. His earlier appointments include associate professor of molecular cancer biology at JNU from 2006 to 2010 and assistant professor-research at the Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Denver, from 2003 to 2006. He also worked as a research associate at the same department from 2001 to 2003, following a post-doctoral Research Fellowship at the Center for Cancer Causation and Prevention, AMC Cancer Research Center, Lakewood, Colorado, from 2000 to 2001. In 2014, he was a visiting scientist at the University of California, Riverside.

Awards and honours

• Indo-US Science and Technology Forum (IUSSTF) Award (2019): Awarded for establishing the "Centre for Integrative Cancer Biology and Therapeutics," a Virtual Networked Centre in collaboration with Jawaharlal Nehru University (JNU) and Stanford University/Oregon Health & Science University (OHSU), Portland, US. ^[26]
• ICMR International Fellowship for Young Biomedical Scientists (2013–14): Awarded by the Indian Council of Medical Research (ICMR) for research conducted at the University of California, Riverside in 2014. ^{[27] [28]}
• Post-doctoral Trainee Award for Prostate Cancer Research (2003): Conferred by the U.S. Army Medical Research and Materiel Command, Department of Defense, received for contributions in prostate cancer research. ^[29]
• Scholar-in-Training Award (2002): Presented by the American Association for Cancer Research, Philadelphia, PA, received for cancer research early in his career. ^[30]

Research publications

Singh's research has received over 16,530 citations and has an h-index of 78 and i10-index of 157. ^[31]

According to Google Scholar, since 2020, he has achieved more than 5,346 citations. His work includes more than 200 research articles published in journals, including Nature , Springer, Elsevier, Wiley and those of the American Association for Cancer Research (AACR). Singh's research spans cancer biology, stem cell research, and other fields in life sciences.

His lab has researched the effects of microgravity on human cells.

Books, chapters and articles

Singh has written book chapters on cancer biology and a complete book Breast Cancer: Biology, Prevention and Treatment. ^[32] Some of his writings are:

• Mechanisms of Resistance in Head and Neck Cancers. N.p.: Frontiers Media SA, 2022. ^[33]
• Cancer Research. United States: Waverly Press, 2009. ^[34]
• Simulated microgravity induces DNA damage concurrent with impairment of DNA repair and activation of cell-type specific DNA damage response in microglial and glioblastoma cells ^[35]
• Simulated microgravity triggers DNA damage and mitochondria-mediated apoptosis through ROS generation in human promyelocytic leukemic cells. ^[36]

References

1. Tailor, Dhanir; Going, Catherine C.; Resendez, Angel; Kumar, Vineet; Nambiar, Dhanya K.; Li, Yang; Dheeraj, Arpit; LaGory, Edward Lewis; Ghoochani, Ali; Birk, Alisha M.; Stoyanova, Tanya; Ye, Jiangbin; Giaccia, Amato J.; Le, Quynh-Thu; Singh, Rana P.; Sledge, George W.; Pitteri, Sharon J.; Malhotra, Sanjay V. (February 2021). "Novel Aza-podophyllotoxin derivative induces oxidative phosphorylation and cell death via AMPK activation in triple-negative breast cancer". British Journal of Cancer. 124 (3): 604–615. doi:10.1038/s41416-020-01137-4. ISSN   1532-1827. PMC   7851402 . PMID   33139797.
2. "UP: गौतमबुद्ध विश्वविद्यालय के नए कुलपति बने प्रो राणा प्रताप सिंह, प्रतिष्ठित कैंसर वैज्ञानिक के नाम से मशहूर". Amar Ujala (in Hindi).
3. "Sri Sri to give lecture at JNU on Nov 13". The Hindu. 5 November 2017.
4. "JNU To Start 4-year UG Programmes, Online Courses In Non-Technical Subjects". Outlook India. 20 November 2020.
5. "JNU to establish special centre for systems medicine". The Hindu. 19 November 2020. Retrieved 20 November 2020.
6. "Rana P Singh". Google Scholar.
7. "Press Trust Of India". www.ptinews.com.
8. Chandraker, Sandip Kumar; Lal, Mishri; Khanam, Farheen; Dhruve, Preeti; Singh, Rana P.; Shukla, Ravindra (25 May 2022). "Therapeutic potential of biogenic and optimized silver nanoparticles using Rubia cordifolia L. leaf extract". Scientific Reports. 12 (1): 8831. Bibcode:2022NatSR..12.8831C. doi:10.1038/s41598-022-12878-y. ISSN   2045-2322. PMC   9133087 . PMID   35614187.
9. Tailor, Dhanir; Going, Catherine C.; Resendez, Angel; Kumar, Vineet; Nambiar, Dhanya K.; Li, Yang; Dheeraj, Arpit; LaGory, Edward Lewis; Ghoochani, Ali; Birk, Alisha M.; Stoyanova, Tanya; Ye, Jiangbin; Giaccia, Amato J.; Le, Quynh-Thu; Singh, Rana P.; Sledge, George W.; Pitteri, Sharon J.; Malhotra, Sanjay V. (February 2021). "Novel Aza-podophyllotoxin derivative induces oxidative phosphorylation and cell death via AMPK activation in triple-negative breast cancer". British Journal of Cancer. 124 (3): 604–615. doi:10.1038/s41416-020-01137-4. ISSN   1532-1827. PMC   7851402 . PMID   33139797.
10. Singh, R. P. (1 March 2003). "Inositol hexaphosphate inhibits growth, and induces G1 arrest and apoptotic death of prostate carcinoma DU145 cells: modulation of CDKI-CDK-cyclin and pRb-related protein-E2F complexes". Carcinogenesis. 24 (3): 555–563. doi:10.1093/carcin/24.3.555. PMID   12663518.
11. "Akash Sabarwal | Harvard Catalyst Profiles | Harvard Catalyst". Connects.catalyst.harvard.edu.
12. Gu, Mallikarjuna; Singh, Rana P.; Dhanalakshmi, Sivanandhan; Mohan, Sarumathi; Agarwal, Rajesh (2006). "Differential effect of silibinin on E2F" . Molecular Cancer Therapeutics. 5 (8): 2121–2130. doi:10.1158/1535-7163.MCT-06-0052. PMID   16928834.
13. "Jawaharlal Nehru University". www.jnu.ac.in.
14. "VC Profile" (PDF). Gautam Buddha University.
15. "JNU To Start 4-year UG Programmes, Online Courses In Non-Technical Subjects". Outlook India. 20 November 2020.
16. "JNU to establish special centre for systems medicine". The Hindu. 19 November 2020. Retrieved 20 November 2020.
17. "Jawaharlal Nehru University considers introducing four-year undergraduate programmes". The New Indian Express. 20 November 2020.
18. Central University of Gujarat https://www.cug.ac.in/pdf/20210517081353f7e3a502cc.pdf.{{cite web}}: Missing or empty |title= (help)
19. "JNU to launch SCEL platform: Digital courses to be offered in various disciplines". India Today. 29 November 2017. Retrieved 29 November 2017.
20. "New JNU V-C starts putting team in place". The Indian Express. 16 March 2022.
21. "Innovation Sprint launched at JNU". The Times of India. 18 April 2021.
22. "ATAL INCUBATION CENTRE-JNU FOUNDATION FOR INNOVATION" (PDF). Jawaharlal Nehru University. Retrieved 17 July 2021.
23. "JNU students block admin building protesting new admission rules". The Times of India. 10 February 2017.
24. Annual Report 2021 (PDF). Central University of Gujarat. p. 4.
25. Central University, Gujarat https://www.cug.ac.in/pdf/20210517081353f7e3a502cc.pdf.{{cite web}}: Missing or empty |title= (help)
26. "Indo-U.S. Virtual Networked Centers - Iusstf". iusstf.org.
27. "Indian Council for Medical Research" (PDF). icmr.nic.in.
28. "Rana P. Singh | Welcome to Jawaharlal Nehru University". www.jnu.ac.in.
29. "India Cancer Research Database". www.incredb.org.
30. "Jawaharlal Nehru University". www.jnu.ac.in.
31. "Scholar Profile". Google Scholars.
32. P Singh, Rana. Red Flower Publications. ISBN   978-81-930735-0-6 . Retrieved 1 January 2015.
33. Mechanisms of Resistance in Head and Neck Cancers. Frontiers Media SA. 8 August 2022. ISBN   978-2-88976-732-8.
34. Cancer Research. Waverly Press. February 2009.
35. Singh, Ragini; Jaiswal, Aishwarya; Singh, Rana P. (March 2024). "Simulated microgravity induces DNA damage concurrent with impairment of DNA repair and activation of cell-type specific DNA damage response in microglial and glioblastoma cells". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1871 (3): 119679. doi: 10.1016/j.bbamcr.2024.119679 . PMID   38272357.
36. Singh, Ragini; Rajput, Mohit; Singh, Rana P. (November 2021). "Simulated microgravity triggers DNA damage and mitochondria-mediated apoptosis through ROS generation in human promyelocytic leukemic cells" . Mitochondrion. 61: 114–124. doi:10.1016/j.mito.2021.09.006. PMID   34571251.