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Reinhard Dallinger | |
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Born | Laives, South Tyrol, Italy | 2 April 1950
Nationality | Austrian |
Known for | Biochemistry and physiology of trace element metabolism of invertebrate animals and environmental toxicology of metals in terrestric and aquatic habitats. |
Scientific career | |
Fields | Zoology |
Institutions | University of Innsbruck |
Reinhard Dallinger (born 2 April 1950) is an Italian-born Austrian zoologist and professor of zoology and ecotoxicology at the University of Innsbruck (retired since 1 October 2017). He works in the field of biochemistry and physiology of trace element metabolism of invertebrate animals and in the field of environmental toxicology of metals in terrestric and aquatic habitats.
Reinhard Dallinger studied zoology and microbiology at the University of Innsbruck, where he received his doctorate at the faculty of natural sciences in 1978. From 1978 to 1981 he was a freelance project manager in the waste management dealing with biological aspects of composting processes. From 1981 to 1989 he was working as a project assistant for zoology at the University of Innsbruck. He was habilitated in 1989 with a work on heavy metals in invertebrate animals. Next he used to work as an associate professor at the Institute of Zoology. Dallinger leads the workgroup of ecotoxicology and molecular physiology. In 2011 he was appointed university professor for eco toxicology at the University of Innsburck. He has retired since 1 October 2017.
A major focus of Dallinger's work is dedicated to the biochemical and cell-physiological mechanisms which govern the accumulation of metallic trace elements in invertebrates and fish. [1] [2] [3] [4] By considering both, physiological and ecological aspects, [5] [6] his work has contributed to our knowledge and understanding of the importance of invertebrates for the trace element transfer in terrestrial and aquatic habitats and for the application of some key representative species as biological indicators in metal-contaminated environments. [7] [8]
A further topic of Dallinger’s ecotoxicological research has focused on aspects of microevolution and adaptation of species and populations to contaminants (metals, pesticides) in combination with different anthropogenic stressors. It could be shown, for example, that the widespread apple pest species, Cydia pomonella , has split into varied adaptable populations over small-scale areas in the alpine region under the selective pressure of pesticide application. Many of these populations have been able to acquire pesticide resistance. [9] [10] Another example of microevolutionary adaptation to environmental pollution has been demonstrated by Dallinger and coworkers in populations of the freshwater sludge worm, Tubifex tubifex . Due to historic and recent metal pollution in European river systems, native populations of this species have split into lineages and cryptic species that differ with respect to their metal resistance. [11]
A rather molecular and biochemical focus of Dallinger’s work is devoted to the mechanisms of detoxification and regulation of metallic trace elements by metal binding proteins belonging to the superfamily of metallothioneins. [12] [13] Dallinger has shown that in certain invertebrate animals (such as, for example, in terrestrial pulmonate snails), metal-selective metallothionein isoforms have evolved that are specifically dedicated to the metabolism of distinct metallic trace elements. [14] The Roman snail ( Helix pomatia ), for example, possesses a copper-selective isoform involved in homeostatic regulation of copper, whereas a cadmium-specific isoform is responsible for the detoxification of this metal by binding it selectively [15] The genes of these isoforms can be upregulated differentially by metal exposure and non-metallic stressors, thus constituting an impressive example for the adaptive diversification of a gene family towards accomplishing trace element-specific physiological tasks. [16] [17] [18] Dallinger was also involved in the elucidation of the three-dimensional structure of a metallothionein with three Cadmium-binding domains from the intertidal periwinkle, Littorina littorea. [19] [20]
Dallinger’s publications are characterized by a comparative and interdisciplinary approach with an integrative perspective, by addressing issues across different layers of biological organization. [4] [11] [14]
1988 Expedition to Lake Tanganyika in cooperation with Christian Sturmbauer (Institute for Zoology, University of Graz). Work on Ethology and nutritional physiology of Tanganyika-Cichlids.
2004-05 and 2005-06 Visiting professor for animal physiology at the Institute for Zoology, University of Vienna
Invertebrates is an umbrella term describing animals that neither develop nor retain a vertebral column, which evolved from the notochord. It is a paraphyletic grouping including all animals excluding the chordate subphylum Vertebrata, i.e. vertebrates. Well-known phyla of invertebrates include arthropods, mollusks, annelids, echinoderms, flatworms, cnidarians, and sponges.
Hemocyanins (also spelled haemocyanins and abbreviated Hc) are proteins that transport oxygen throughout the bodies of some invertebrate animals. These metalloproteins contain two copper atoms that reversibly bind a single oxygen molecule (O2). They are second only to hemoglobin in frequency of use as an oxygen transport molecule. Unlike the hemoglobin in red blood cells found in vertebrates, hemocyanins are not confined in blood cells, but are instead suspended directly in the hemolymph. Oxygenation causes a color change between the colorless Cu(I) deoxygenated form and the blue Cu(II) oxygenated form.
Aestivation is a state of animal dormancy, similar to hibernation, although taking place in the summer rather than the winter. Aestivation is characterized by inactivity and a lowered metabolic rate, that is entered in response to high temperatures and arid conditions. It takes place during times of heat and dryness, which are often the summer months.
Metallothionein (MT) is a family of cysteine-rich, low molecular weight proteins. They are localized to the membrane of the Golgi apparatus. MTs have the capacity to bind both physiological and xenobiotic heavy metals through the thiol group of its cysteine residues, which represent nearly 30% of its constituent amino acid residues.
Isopoda is an order of crustaceans. Members of this group are called Isopods and include both terrestrial and aquatic species such as woodlice. All have rigid, segmented exoskeletons, two pairs of antennae, seven pairs of jointed limbs on the thorax, and five pairs of branching appendages on the abdomen that are used in respiration. Females brood their young in a pouch under their thorax.
Copper fist is an N-terminal domain involved in copper-dependent DNA binding. It is named for its resemblance to a fist closed around a penny. Functionally, the "penny" is a collection of copper ions and the "knuckles" of the fist are proteins that interact with the promoter of the metallothionein gene, enhancing its transcription by creating a more stable binding site for RNA polymerase during transcription, an essential step in DNA replication.
The superorder Peracarida is a large group of malacostracan crustaceans, having members in marine, freshwater, and terrestrial habitats. They are chiefly defined by the presence of a brood pouch, or marsupium, formed from thin flattened plates (oostegites) borne on the basalmost segments of the legs. Peracarida is one of the largest crustacean taxa and includes about 12,000 species. Most members are less than 2 cm (0.8 in) in length, but the largest is probably the giant isopod which can reach 76 cm (30 in). The earliest known perecaridian was Oxyuropoda ligioides, a fossil of which has been found dating to the Late Devonian of Ireland.
Terrestrial animals are animals that live predominantly or entirely on land, as compared with aquatic animals, which live predominantly or entirely in the water, and semiaquatic animals, which rely on both aquatic and terrestrial habitats. Some groups of insects are terrestrial, such as ants, butterflies, earwigs, cockroaches, grasshoppers and many others, while other groups are partially aquatic, such as mosquitoes and dragonflies, which pass their larval stages in water.
QPNC-PAGE, or QuantitativePreparativeNativeContinuousPolyacrylamideGel Electrophoresis, is a bioanalytical, one-dimensional, high-resolution and high-precision electrophoresis technique applied in biochemistry and bioinorganic chemistry to separate proteins quantitatively by isoelectric point and by continuous elution from a gel column.
Natural resistance-associated macrophage protein 2, also known as divalent metal transporter 1 (DMT1) and divalent cation transporter 1 (DCT1), is a protein that in humans is encoded by the SLC11A2 gene. DMT1 represents a large family of orthologous metal ion transporter proteins that are highly conserved from bacteria to humans.
Basileostylus bollonsi, common name the New Zealand flax snail or pupuharakeke, is a species of air-breathing land snail, a terrestrial pulmonate gastropod mollusc in the family Bothriembryontidae.
Metallothionein-2 is a metallothionein protein that in humans is encoded by the MT2A gene.
Metallothionein-1E is a protein that in humans is encoded by the MT1E gene.
A woodlouse is any crustacean belonging to the suborder Oniscidea within the order Isopoda. They get their name from often being found in old wood, and from louse, a parasitic insect, although woodlice are neither parasitic nor insects.
A newt is a salamander in the subfamily Pleurodelinae. The terrestrial juvenile phase is called an eft. Unlike other members of the family Salamandridae, newts are semiaquatic, alternating between aquatic and terrestrial habitats. Not all aquatic salamanders are considered newts, however. More than 100 known species of newts are found in North America, Europe, North Africa and Asia. Newts metamorphose through three distinct developmental life stages: aquatic larva, terrestrial juvenile (eft), and adult. Adult newts have lizard-like bodies and return to the water every year to breed, otherwise living in humid, cover-rich land habitats.
The sensory organs of gastropods include olfactory organs, eyes, statocysts and mechanoreceptors. Gastropods have no sense of hearing.
The carbonic anhydrases form a family of enzymes that catalyze the interconversion between carbon dioxide and water and the dissociated ions of carbonic acid. The active site of most carbonic anhydrases contains a zinc ion. They are therefore classified as metalloenzymes. The enzyme maintains acid-base balance and helps transport carbon dioxide.
Robert J. Cousins is an American nutritional biochemist who has researched the metabolism of heavy metals, especially zinc. He has served as president of the Federation of American Societies for Experimental Biology (FASEB) and the American Society for Nutrition (ASN). He was recognized with membership in the National Academy of Sciences in 2000 and served as editor of the Annual Review of Nutrition for ten years.
Eusthenia spectabilis is a very large species of stonefly in the family of giant stoneflies, Eustheniidae. At 4 cm (1.6 in) Eusthenia spectabilis is the largest member of the genus and emerges later than other similar species.