Renin receptor

ATP6AP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3LBS, 3LC8
Identifiers
Aliases	ATP6AP2 , APT6M8-9, ATP6IP2, ATP6M8-9, ELDF10, M8-9, MRXE, MRXSH, MSTP009, PRR, RENR, XMRE, XPDS, HT028, ATPase H+ transporting accessory protein 2, CDG2R
External IDs	OMIM: 300556; MGI: 1917745; HomoloGene: 38097; GeneCards: ATP6AP2; OMA:ATP6AP2 - orthologs
Gene location (Human) Chr. X chromosome (human) [1] Band Xp11.4 Start 40,579,372 bp [1] End 40,606,848 bp [1]
Gene location (Mouse) Chr. X chromosome (mouse) [2] Band X|X A1.1 Start 12,454,040 bp [2] End 12,483,288 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in visceral pleura tibia germinal epithelium parietal pleura epithelium of nasopharynx retinal pigment epithelium mucosa of paranasal sinus orbitofrontal cortex lateral nuclear group of thalamus renal medulla Top expressed in Epithelium of choroid plexus Paneth cell ciliary body iris retinal pigment epithelium conjunctival fornix substantia nigra medial dorsal nucleus medial geniculate nucleus aortic valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding enzyme binding signaling receptor activity Cellular component integral component of membrane plasma membrane extracellular exosome membrane external side of plasma membrane neuron projection cell body tertiary granule membrane ficolin-1-rich granule membrane extracellular space apical plasma membrane Biological process positive regulation of transforming growth factor beta1 production rostrocaudal neural tube patterning head morphogenesis regulation of MAPK cascade eye pigmentation angiotensin maturation positive regulation of Wnt signaling pathway neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10159 70495 Ensembl ENSG00000182220 ENSMUSG00000031007 UniProt O75787 Q9CYN9 RefSeq (mRNA) NM_005765 NM_027439 RefSeq (protein) NP_005756 NP_081715 Location (UCSC) Chr X: 40.58 – 40.61 Mb Chr X: 12.45 – 12.48 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The renin receptor also known as ATPase H(+)-transporting lysosomal accessory protein 2, or the prorenin receptor, is a protein that in humans is encoded by the ATP6AP2 gene. ^{[5] [6] [7]}

Function

The renin receptor binds renin and prorenin. Binding of renin to this receptor induces the conversion of angiotensinogen to angiotensin I. ^[8]

This protein is associated with proton-translocating ATPases which have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis. There are three classes of ATPases- F, P, and V. The vacuolar (V-type) ATPases have a transmembrane proton-conducting sector and an extramembrane catalytic sector. This protein has been found associated with the transmembrane sector of the V-type ATPases. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000182220 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031007 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ludwig J, Kerscher S, Brandt U, Pfeiffer K, Getlawi F, Apps DK, Schagger H (Jun 1998). "Identification and characterization of a novel 9.2-kDa membrane sector-associated protein of vacuolar proton-ATPase from chromaffin granules". J Biol Chem. 273 (18): 10939–47. doi: 10.1074/jbc.273.18.10939 . PMID   9556572.
6. Demirci FY, White NJ, Rigatti BW, Lewis KF, Gorin MB (Oct 2001). "Identification, genomic structure, and screening of the vacuolar proton-ATPase membrane sector-associated protein M8-9 gene within the COD1 critical region (Xp11.4)". Mol Vis. 7: 234–9. PMID   11590366.
7. "Entrez Gene: ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2".
8. Nguyen G, Delarue F, Burcklé C, Bouzhir L, Giller T, Sraer JD (June 2002). "Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin". J. Clin. Invest. 109 (11): 1417–27. doi:10.1172/JCI14276. PMC   150992 . PMID   12045255.

Further reading

• Kaneshiro Y, Ichihara A, Sakoda M, et al. (2007). "Slowly progressive, angiotensin II-independent glomerulosclerosis in human (pro)renin receptor-transgenic rats" (PDF). J. Am. Soc. Nephrol. 18 (6): 1789–95. doi: 10.1681/ASN.2006091062 . PMID   17494887.
• Schefe JH, Menk M, Reinemund J, et al. (2007). "A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein". Circ. Res. 99 (12): 1355–66. CiteSeerX   10.1.1.486.8053 . doi: 10.1161/01.RES.0000251700.00994.0d . PMID   17082479.
• Kaneshiro Y, Ichihara A, Takemitsu T, et al. (2006). "Increased expression of cyclooxygenase-2 in the renal cortex of human prorenin receptor gene-transgenic rats". Kidney Int. 70 (4): 641–6. doi: 10.1038/sj.ki.5001627 . PMID   16807542.
• Burcklé CA, Jan Danser AH, Müller DN, et al. (2006). "Elevated blood pressure and heart rate in human renin receptor transgenic rats". Hypertension. 47 (3): 552–6. doi: 10.1161/01.HYP.0000199912.47657.04 . PMID   16401765.
• Huang Y, Wongamorntham S, Kasting J, et al. (2006). "Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms". Kidney Int. 69 (1): 105–13. doi: 10.1038/sj.ki.5000011 . PMID   16374430.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID   16303743.
• Ramser J, Abidi FE, Burckle CA, et al. (2005). "A unique exonic splice enhancer mutation in a family with X-linked mental retardation and epilepsy points to a novel role of the renin receptor". Hum. Mol. Genet. 14 (8): 1019–27. doi:10.1093/hmg/ddi094. PMID   15746149.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Hedera P, Alvarado D, Beydoun A, Fink JK (2002). "Novel mental retardation-epilepsy syndrome linked to Xp21.1-p11.4". Ann. Neurol. 51 (1): 45–50. doi:10.1002/ana.10051. hdl: 2027.42/34887 . PMID   11782983. S2CID   18107509.
• Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi: 10.1073/pnas.160270997 . PMC   16901 . PMID   10931946.

External links

• ATP6AP2 human gene location in the UCSC Genome Browser .
• ATP6AP2 human gene details in the UCSC Genome Browser .