Robert Thompson Clubb is an American biochemist who researches the structural biology of bacterial pathogenesis. He is a professor of chemistry, biochemistry, and molecular biology at the University of California, Los Angeles, where he also directs the Clubb Lab and co-directs the Nuclear Magnetic Resonance Core Technology Center.
Robert Thompson Clubb was born to surgical nurse Vera Alice Thompson and Jerome M. Clubb a professor of history.[1][2] Clubb has a sister.[2] He earned a bachelor of science at University of Wisconsin.[3]
Clubb completed a doctor of philosophy in biological chemistry at University of Michigan.[3] His 1993 dissertation was titled Application and development of multi-dimensional NMR spectroscopic techniques to study protein structure in solution.[1] Clubb's advisors and co-chairs of his thesis committee were Gerhard Wagner and Martha L. Ludwig. He received training in practical nuclear magnetic resonance spectroscopy from Venkataraman Thanabal.[1] From 1993 to 1996, Clubb was a post-doctoral research fellow at the National Institutes of Health. His advisors were G. Marius Clore and Angela Gronenborn.[4]
Career
Clubb's research has focused on elucidating the structural and biochemical mechanisms that bacterial pathogens use to display virulence factors and acquire nutrients from their hosts.[5] Beginning in the early 2000s, he investigated how Gram-positive bacteria assemble pili and wall teichoic acids, advancing understanding of bacterial adhesion and cell wall physiology.[5] Since the 2010s, his work has also centered on the molecular basis of heme-iron acquisition from hemoglobin by pathogens like Staphylococcus aureus and Corynebacterium diphtheriae, and more recently, he has led efforts to discover antibiotics targeting virulence factor assembly pathways, including Sortase A and wall teichoic acid biosynthesis.[5]
Clubb is a professor of chemistry, biochemistry, and molecular biology at University of California, Los Angeles. He is the lab director of the Clubb Lab and co-director and staff researcher at the Nuclear Magnetic Resonance (NMR) Core Technology Center (DOE).[3]
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