He released his debut film 7 Days in 2021. The romantic comedy film was based in part on his experiences as a medical professional in the early days of the COVID-19 pandemic, in 2021.[5] The film won the 2022 Independent Spirit Award for Best First Feature.[6]
In 2022, he was a co-writer of the screenplay for Call Jane.[7]
Sethi came out as gay at age 30. He is married to actor Karan Soni, who has been a credited cowriter and/or cast member in all of Sethi's films to date.[1]
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