Roslin Institute

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The Roslin Institute
Roslin Institute.JPG
Established1993
DirectorProfessor Bruce Whitelaw
Location,
EH25 9RG
,
Scotland, UK

55°51′56″N03°11′54″W / 55.86556°N 3.19833°W / 55.86556; -3.19833
CampusEaster Bush
Affiliations University of Edinburgh, BBSRC
Mascot Dolly the Sheep
Website www.ed.ac.uk/roslin
The Roslin Institute logo.gif

The Roslin Institute is an animal sciences research institute at Easter Bush, Midlothian, Scotland, part of the University of Edinburgh, and is funded by the Biotechnology and Biological Sciences Research Council.

Contents

It is best known for creating Dolly the sheep in 1996, the first mammal to be successfully cloned from an adult cell.

History

Institute of Animal Genetics (1917–1980)

The Roslin Institute has its roots in the University of Edinburgh's Institute of Animal Genetics (IAG), which was founded in 1917 under the direction of Francis Albert Eley Crew. [1]

Poultry Research Centre (1947–1986)

The Poultry Research Centre (PRC) was founded in 1947 by the Agricultural Research Council (ARC). [2] The new institute used expertise and material from the IAG, and its laboratories were located adjacent to the IAG's building on the university's King's Buildings campus. A second site housing larger experiments was located on the Bush Estate, south of Edinburgh. [3]

In 1971, the institute's experimental facility moved from the Bush Estate to a larger site near the village of Roslin, and the main laboratories moved to the same site in 1980. [3]

Animal Breeding Research Organisation (1947–1986)

The Animal Breeding Research Organisation (ABRO) was founded at the same time as the PRC in 1947, again using the IAG's expertise. Its research focused mainly on genetic improvement of cattle, pigs and sheep. [4]

In the 1980s, under the direction of John King and Roger Land, ABRO's research began a shift towards molecular biology, which was key in laying the groundwork for the institute's work on cloning in the 1990s. [5]

Edinburgh Research Station, Institute of Animal Physiology and Genetics Research (1986–1993)

In 1986, the Poultry Research Centre and the Animal Breeding Research Organisation merged with the Institute of Animal Physiology, based in Babraham, Cambridgeshire, to form the Institute of Animal Physiology and Genetics Research (IAPGR). [4] The PRC's buildings in Roslin became the IAPGR's Edinburgh Research Station, with the former ABRO facilities progressively relocating there between 1986 and 1989. [6]

The Roslin Institute (1993–2008)

The IAPGR's sites at Babraham and Roslin became two independent institutes owned by the Biotechnology and Biological Sciences Research Council in 1993 – the Babraham Institute and the Roslin Institute. Animal genetics research had been gradually consolidating on the Roslin site since 1986, [6] and all agricultural research at Babraham had ceased by 1998.

The institute became a company limited by guarantee and a charity registered in Scotland, with the BBSRC as its sponsor, in 1995. [7]

University of Edinburgh (2008–present)

In 2006, the BBSRC announced that the institute would move to a new site on the University of Edinburgh's Easter Bush campus, under the direction of David Hume. [8] As part of the plans, the Roslin Institute merged with the Neuropathogenesis Unit of the Institute for Animal Health, well known for its role in deciphering the biology of transmissible spongiform encephalopathies and this was headed by Jean Manson.

In April 2008, the combined institute became part of the University of Edinburgh's Royal (Dick) School of Veterinary Studies, and the institute's 197 staff members became University of Edinburgh employees on 1 May. [7] [9] The move to Easter Bush was completed in March 2011, with the opening of a new £60.6M building designed by HDR, Inc. [10] Under the original plans, the new institute was to be known as EBRC, [11] but the institute ultimately retained the Roslin name.

In February 2020, Bruce Whitelaw became interim director of the institute, replacing Eleanor Riley, who had been director since 2017. [12]

Honours

Dolly the sheep on display at the National Museum of Scotland World-famous sheep (28147270737).jpg
Dolly the sheep on display at the National Museum of Scotland

In 1996, the institute won international fame when Ian Wilmut, Keith Campbell, and their colleagues created Dolly the sheep, the first mammal to be successfully cloned from an adult cell, at the institute. [13] [14] [15] A year later, two other sheep named Polly and Molly were cloned, each of which contained a human gene.

Roslin has made many other contributions to animal science and biotechnology research, especially in the area of livestock improvement and welfare through the application of quantitative genetics. In 2007, a Roslin team developed genetically modified chickens capable of laying eggs containing proteins needed to make cancer-fighting drugs.

Objectives

The Roslin Institute aims to enhance the lives of animals and humans through world-class research in animal biology. The principal objectives are to:

Research

Research at the Roslin Institute is categorised into four scientific divisions: [16]

Three Institute Strategic Programmes, which are funded by the Biotechnology and Biological Sciences Research Council, span the Divisions of the institute.

Directors

Poultry Research Centre

Animal Breeding Research Organisation

Edinburgh Research Station

Roslin Institute

Notable people

Related Research Articles

<span class="mw-page-title-main">Dolly (sheep)</span> First cloned mammal (1996–2003)

Dolly was a female Finn-Dorset sheep and the first mammal that was cloned from an adult somatic cell. She was cloned by associates of the Roslin Institute in Scotland, using the process of nuclear transfer from a cell taken from a mammary gland. Her cloning proved that a cloned organism could be produced from a mature cell from a specific body part. Contrary to popular belief, she was not the first animal to be cloned.

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<span class="mw-page-title-main">Anthony John Clark</span>

Anthony John Clark OBE FRSE was an English molecular biologist who was a founder of applying molecular technology to farm animals. He was director of the Roslin Institute from 2002 to 2004.

Sir Ian Wilmut, OBE FRS FMedSci FRSE is an English embryologist and Chair of the Scottish Centre for Regenerative Medicine at the University of Edinburgh. He is best known as the leader of the research group that in 1996 first cloned a mammal from an adult somatic cell, a Finnish Dorset lamb named Dolly. He was appointed OBE in 1999 for services to embryo development and knighted in the 2008 New Year Honours. He together with Keith Campbell and Shinya Yamanaka jointly received the 2008 Shaw Prize for Medicine and Life Sciences "for their works on the cell differentiation in mammals."

Polly and Molly, two ewes, were the first mammals to have been successfully cloned from an adult somatic cell and to be transgenic animals at the same time. This is not to be confused with Dolly the Sheep, the first animal to be successfully cloned from an adult somatic cell where there wasn’t modification carried out on the adult donor nucleus. Polly and Molly, like Dolly the Sheep, were cloned at the Roslin Institute in Edinburgh, Scotland.

<span class="mw-page-title-main">Babraham Institute</span> Life sciences research institution

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<span class="mw-page-title-main">Biologist</span> Scientist studying living organisms

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Megan and Morag, two domestic sheep, were the first mammals to have been successfully cloned from differentiated cells. They are not to be confused with Dolly the sheep which was the first animal to be successfully cloned from an adult somatic cell or Polly the sheep which was the first cloned and transgenic animal. Megan and Morag, like Dolly and Polly, were cloned at the Roslin Institute in Edinburgh, Scotland in 1995.

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Alan William Greenwood CBE FRSE was a Scottish zoologist and geneticist, who helped pave the way to creating Dolly the Sheep. He served as Director of the Poultry Research Centre from 1947 until 1962.

<i>In re Roslin Institute</i> (Edinburgh) 2014 decision of the United States Court of Appeals for the Federal Circuit

In re Roslin Institute (Edinburgh), 750 F.3d 1333 (Fed. Cir. 2014), is a 2014 decision of the United States Court of Appeals for the Federal Circuit rejecting a patent for a cloned sheep known as "Dolly the Sheep"— the first mammal ever cloned from an adult somatic cell.

Roger Burton Land FRSE was a 20th century British animal geneticist. As head of the Edinburgh Research Station he was one of the several scientists responsible for laying the groundwork for the creation of Dolly the Sheep. The Roger Land Building within the University of Edinburgh's King's Buildings complex is named after him.

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Grahame Bulfield, CBE, FRSE, Hon FRASE is an English geneticist, vice-principal and Emeritus Professor of Genetics at the University of Edinburgh. He is best known as the former director and chief executive of the Roslin Institute, Edinburgh, when in 1996 the research group led by Ian Wilmut first cloned a mammal from an adult somatic cell, a Finnish Dorset lamb named Dolly.

Janet Scott Salmon Blyth was a Scottish geneticist who specialised in poultry genetics and husbandry in the interwar and post-war decades and played a prominent role in establishing the Poultry Research Centre, one of several institutions that would eventually be amalgamated to form the Roslin Institute.

References

  1. "Animal Genetics". University of Edinburgh Our History. Retrieved 25 September 2020.
  2. Shirley Williams (20 May 1977). "Poultry Research Centre". Parliamentary Debates (Hansard) . Vol. 932. United Kingdom: House of Commons.
  3. 1 2 "Poultry Research Centre (1947–1986) (research institution)". University of Edinburgh Archives Online. Retrieved 25 September 2020.
  4. 1 2 "Animal Breeding Research Organisation. ABRO (1945–1986)". University of Edinburgh Archives Online. Retrieved 25 September 2020.
  5. Wilmut, Ian; Campbelll, Keith; Tudge, Colin (2000). The Second Creation: Dolly and the Age of Biological Control. Headline Book Publishing.
  6. 1 2 "History of the Institute". The Roslin Institute. Archived from the original on 25 March 2020. Retrieved 25 September 2020.
  7. 1 2 "Roslin Institute – History". Roslin Institute. Archived from the original on 29 November 2009.
  8. "First director appointed to new research centre". BBSRC . Archived from the original on 27 January 2007.
  9. BBSRC Annual Report and Accounts 2007–2008 (PDF) (Report). Biotechnology and Biological Sciences Research Council. 2008.
  10. "New home for Roslin Institute". Veterinary Record. 169 (2): 34. 2011. doi:10.1136/vr.d4061. S2CID   219199064.
  11. BBSRC Annual Report and Accounts 2006–2007 (PDF) (Report). Biotechnology and Biological Sciences Research Council. 2007.
  12. "Professor Eleanor Riley, Director of the Roslin Institute to step down". BBSRC . Archived from the original on 6 July 2020. Retrieved 6 July 2020.
  13. Campbell, K. H. S.; McWhir, J.; Ritchie, W. A.; Wilmut, I. (1996). "Sheep cloned by nuclear transfer from a cultured cell line". Nature. 380 (6569): 64–66. Bibcode:1996Natur.380...64C. doi:10.1038/380064a0. PMID   8598906. S2CID   3529638.
  14. Firn, D. (1999). "Roslin Institute upset by human cloning suggestions". Nature Medicine. 5 (3): 253. doi: 10.1038/6449 . PMID   10086368. S2CID   41278352.
  15. Jayaraman, K. S. (1998). "India's short cow drags Roslin Institute into controversy". Nature. 394 (6696): 821. Bibcode:1998Natur.394..821J. doi: 10.1038/29621 . PMID   9732859.
  16. "Research at Roslin Institute".
  17. "Bulfield, Grahame, 1941–: (geneticist, formerly director and chief executive, Roslin Institute, Edinburgh and vice-principal, University of Edinburgh)". University of Edinburgh Archives Online. Retrieved 26 September 2020.
  18. 1 2 "Interim director of The Roslin Institute announced". The Roslin Institute. Archived from the original on 7 April 2019. Retrieved 20 September 2020.
  19. "New Director starts at The Roslin Institute". The Roslin Institute. Archived from the original on 7 April 2019. Retrieved 20 September 2020.
  20. "Gene editing specialist to lead Roslin Institute". Vet Times. 5 April 2022. Retrieved 12 August 2022.