Established | 1993 |
---|---|
Director | Professor Bruce Whitelaw |
Location | , EH25 9RG , Scotland, UK 55°51′56″N03°11′54″W / 55.86556°N 3.19833°W |
Campus | Easter Bush |
Affiliations | University of Edinburgh, BBSRC |
Mascot | Dolly the Sheep |
Website | www |
The Roslin Institute is an animal sciences research institute at Easter Bush, Midlothian, Scotland, part of the University of Edinburgh, and is funded by the Biotechnology and Biological Sciences Research Council.
It is best known for creating Dolly the sheep in 1996, the first mammal to be successfully cloned from an adult cell.
The Roslin Institute has its roots in the University of Edinburgh's Institute of Animal Genetics (IAG), which was founded in 1917 under the direction of Francis Albert Eley Crew. [1]
The Poultry Research Centre (PRC) was founded in 1947 by the Agricultural Research Council (ARC). [2] The new institute used expertise and material from the IAG, and its laboratories were located adjacent to the IAG's building on the university's King's Buildings campus. A second site housing larger experiments was located on the Bush Estate, south of Edinburgh. [3]
In 1971, the institute's experimental facility moved from the Bush Estate to a larger site near the village of Roslin, and the main laboratories moved to the same site in 1980. [3]
The Animal Breeding Research Organisation (ABRO) was founded at the same time as the PRC in 1947, again using the IAG's expertise. Its research focused mainly on genetic improvement of cattle, pigs and sheep. [4]
In the 1980s, under the direction of John King and Roger Land, ABRO's research began a shift towards molecular biology, which was key in laying the groundwork for the institute's work on cloning in the 1990s. [5]
In 1986, the Poultry Research Centre and the Animal Breeding Research Organisation merged with the Institute of Animal Physiology, based in Babraham, Cambridgeshire, to form the Institute of Animal Physiology and Genetics Research (IAPGR). [4] The PRC's buildings in Roslin became the IAPGR's Edinburgh Research Station, with the former ABRO facilities progressively relocating there between 1986 and 1989. [6]
The IAPGR's sites at Babraham and Roslin became two independent institutes owned by the Biotechnology and Biological Sciences Research Council in 1993 – the Babraham Institute and the Roslin Institute. Animal genetics research had been gradually consolidating on the Roslin site since 1986, [6] and all agricultural research at Babraham had ceased by 1998.
The institute became a company limited by guarantee and a charity registered in Scotland, with the BBSRC as its sponsor, in 1995. [7]
In 2006, the BBSRC announced that the institute would move to a new site on the University of Edinburgh's Easter Bush campus, under the direction of David Hume. [8] As part of the plans, the Roslin Institute merged with the Neuropathogenesis Unit of the Institute for Animal Health, well known for its role in deciphering the biology of transmissible spongiform encephalopathies and this was headed by Jean Manson.
In April 2008, the combined institute became part of the University of Edinburgh's Royal (Dick) School of Veterinary Studies, and the institute's 197 staff members became University of Edinburgh employees on 1 May. [7] [9] The move to Easter Bush was completed in March 2011, with the opening of a new £60.6M building designed by HDR, Inc. [10] Under the original plans, the new institute was to be known as EBRC, [11] but the institute ultimately retained the Roslin name.
In February 2020, Bruce Whitelaw became interim director of the institute, replacing Eleanor Riley, who had been director since 2017. [12]
In 1996, the institute won international fame when Ian Wilmut, Keith Campbell, and their colleagues created Dolly the sheep, the first mammal to be successfully cloned from an adult cell, at the institute. [13] [14] [15] A year later, two other sheep named Polly and Molly were cloned, each of which contained a human gene.
Roslin has made many other contributions to animal science and biotechnology research, especially in the area of livestock improvement and welfare through the application of quantitative genetics. In 2007, a Roslin team developed genetically modified chickens capable of laying eggs containing proteins needed to make cancer-fighting drugs.
The Roslin Institute aims to enhance the lives of animals and humans through world-class research in animal biology. The principal objectives are to:
Research at the Roslin Institute is categorised into four scientific divisions: [16]
Three Institute Strategic Programmes, which are funded by the Biotechnology and Biological Sciences Research Council, span the Divisions of the institute.
Dolly was a female Finn-Dorset sheep and the first mammal that was cloned from an adult somatic cell. She was cloned by associates of the Roslin Institute in Scotland, using the process of nuclear transfer from a cell taken from a mammary gland. Her cloning proved that a cloned organism could be produced from a mature cell from a specific body part. Contrary to popular belief, she was not the first animal to be cloned.
Sir Robert Brian Heap is a British biological scientist.
Biotechnology and Biological Sciences Research Council (BBSRC), part of UK Research and Innovation, is a non-departmental public body (NDPB), and is the largest UK public funder of non-medical bioscience. It predominantly funds scientific research institutes and university research departments in the UK.
The Pirbright Institute is a research institute in Surrey, England, dedicated to the study of infectious diseases of farm animals. It forms part of the UK government's Biotechnology and Biological Sciences Research Council (BBSRC). The institute employs scientists, vets, PhD students and operations staff.
Anthony John Clark OBE FRSE was an English molecular biologist who was a founder of applying molecular technology to farm animals. He was director of the Roslin Institute from 2002 to 2004.
Sir Ian Wilmut, OBE FRS FMedSci FRSE is an English embryologist and Chair of the Scottish Centre for Regenerative Medicine at the University of Edinburgh. He is best known as the leader of the research group that in 1996 first cloned a mammal from an adult somatic cell, a Finnish Dorset lamb named Dolly. He was appointed OBE in 1999 for services to embryo development and knighted in the 2008 New Year Honours. He together with Keith Campbell and Shinya Yamanaka jointly received the 2008 Shaw Prize for Medicine and Life Sciences "for their works on the cell differentiation in mammals."
Polly and Molly, two ewes, were the first mammals to have been successfully cloned from an adult somatic cell and to be transgenic animals at the same time. This is not to be confused with Dolly the Sheep, the first animal to be successfully cloned from an adult somatic cell where there wasn’t modification carried out on the adult donor nucleus. Polly and Molly, like Dolly the Sheep, were cloned at the Roslin Institute in Edinburgh, Scotland.
The Babraham Institute is a life sciences research institution and a partner organisation of the University of Cambridge. The Babraham Institute is based on the Babraham Research Campus, partly occupying a former manor house, but also laboratory and science facility buildings on the campus, surrounded by an extensive parkland estate, just south of Cambridge, England. It is an independent and charitable organization which is involved in biomedical research, including healthy aging and molecular biology. The director is Dr Simon Cook who also leads the Institute's signalling research programme.
A biologist is a scientist who conducts research in biology. Biologists are interested in studying life on Earth, whether it is an individual cell, a multicellular organism, or a community of interacting populations. They usually specialize in a particular branch of biology and have a specific research focus.
The University of Veterinary and Animal Sciences, originally known as Lahore Veterinary College, is a public university located in Lahore, Punjab, Pakistan. It is accredited by the Pakistan Veterinary Medical Council (PVMC). It has additional teaching campuses in rural areas of the Punjab, Pattoki and Jhang.
Megan and Morag, two domestic sheep, were the first mammals to have been successfully cloned from differentiated cells. They are not to be confused with Dolly the sheep which was the first animal to be successfully cloned from an adult somatic cell or Polly the sheep which was the first cloned and transgenic animal. Megan and Morag, like Dolly and Polly, were cloned at the Roslin Institute in Edinburgh, Scotland in 1995.
The Institute of Biological, Environmental and Rural Sciences (IBERS) is a department of Aberystwyth University within its Faculty of Earth and Life Sciences, and is located in Aberystwyth, Ceredigion, Wales. It has a remit for teaching, research and business innovation in the area of bio-sciences, land use and the rural economy.
Keith Henry Stockman Campbell was a British biologist who was a member of the team at Roslin Institute that in 1996 first cloned a mammal, a Finnish Dorset lamb named Dolly, from fully differentiated adult mammary cells. He was Professor of Animal Development at the University of Nottingham. In 2008, he received the Shaw Prize for Medicine and Life Sciences jointly with Ian Wilmut and Shinya Yamanaka for "their works on the cell differentiation in mammals".
Alan William Greenwood CBE FRSE was a Scottish zoologist and geneticist, who helped pave the way to creating Dolly the Sheep. He served as Director of the Poultry Research Centre from 1947 until 1962.
In re Roslin Institute (Edinburgh), 750 F.3d 1333 (Fed. Cir. 2014), is a 2014 decision of the United States Court of Appeals for the Federal Circuit rejecting a patent for a cloned sheep known as "Dolly the Sheep"— the first mammal ever cloned from an adult somatic cell.
Roger Burton Land FRSE was a 20th century British animal geneticist. As head of the Edinburgh Research Station he was one of the several scientists responsible for laying the groundwork for the creation of Dolly the Sheep. The Roger Land Building within the University of Edinburgh's King's Buildings complex is named after him.
(Dorothy) Claire Wathes née Bulman is a British veterinary researcher who studies the reproduction of farm animals. She is known for her work on infertility in dairy cattle. As of 2018, she is a professor of veterinary reproduction at the Royal Veterinary College in Hatfield.
Hugh Paterson Donald (1908–1989) was a New Zealand-born, British biologist, noteworthy as an important contributor to Peter Medawar's research on skin grafts.
Grahame Bulfield, CBE, FRSE, Hon FRASE is an English geneticist, vice-principal and Emeritus Professor of Genetics at the University of Edinburgh. He is best known as the former director and chief executive of the Roslin Institute, Edinburgh, when in 1996 the research group led by Ian Wilmut first cloned a mammal from an adult somatic cell, a Finnish Dorset lamb named Dolly.
Janet Scott Salmon Blyth was a Scottish geneticist who specialised in poultry genetics and husbandry in the interwar and post-war decades and played a prominent role in establishing the Poultry Research Centre, one of several institutions that would eventually be amalgamated to form the Roslin Institute.