Ruzinurad

Last updated
Ruzinurad
Ruzinurad.svg
Legal status
Legal status
  • Investigational
Identifiers
  • 1-(6-Bromoquinolin-4-yl)sulfanylcyclobutane-1-carboxylic acid
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
Formula C14H12BrNO2S
Molar mass 338.22 g·mol−1
3D model (JSmol)
  • C1CC(C1)(C(=O)O)SC2=C3C=C(C=CC3=NC=C2)Br
  • InChI=1S/C14H12BrNO2S/c15-9-2-3-11-10(8-9)12(4-7-16-11)19-14(13(17)18)5-1-6-14/h2-4,7-8H,1,5-6H2,(H,17,18)
  • Key:QGBWIYLNOBYNDL-UHFFFAOYSA-N

Ruzinurad (SHR4640) is a selective urate transporter 1 (URAT1) inhibitor in development for hyperuricaemia and gout. It is developed by Jiangsu Hengrui. [1] [2] [3] [4] [5] [6]

References

  1. ↑ Lin, Yanwei; Chen, Xiaoxiang; Ding, Huihua; Ye, Ping; Gu, Jieruo; Wang, Xiaoxia; Jiang, Zhenyu; Li, Detian; Wang, Zhongming; Long, Wubin; Li, Zhijun; Jiang, Gengru; Li, Xiaomei; Bi, Liqi; Jiang, Lindi; Wu, Jian; Guo, Lian; Cai, Xiaoyan; Lu, Xin; Chen, Qinkai; Chen, Hong; Peng, Ai; Zuo, Xiaoxia; Ning, Rui; Zhang, Zhe; Tai, Yanfei; Zhang, Tao; Bao, Chunde (3 November 2021). "Efficacy and safety of a selective URAT1 inhibitor SHR4640 in Chinese subjects with hyperuricaemia: a randomized controlled phase II study". Rheumatology. 60 (11): 5089–5097. doi:10.1093/rheumatology/keab198. ISSN   1462-0332. PMID   33693494.
  2. ↑ Wang, Chenjing; Yu, Qing; Jiang, Xin; Deng, Yujie; Sun, Feifei; Li, Xin; Tao, Ye; Lin, Pingping; Ma, Yaping; Zhu, Yuxian; Li, Chengqian; Cao, Yu (February 2023). "A Drug–Drug Interaction Study of a Novel Selective Urate Reabsorption Inhibitor, SHR4640, and Xanthine Oxidase Inhibitor, Febuxostat, in Patients With Primary Hyperuricemia". The Journal of Clinical Pharmacology. 63 (2): 239–249. doi:10.1002/jcph.2159. PMID   36131360. S2CID   252437511.
  3. ↑ Lin, Yanwei; Chen, Xiaoxiang; Ding, Huihua; Ye, Ping; Gu, Jieruo; Wang, Xiaoxia; Jiang, Zhenyu; Li, Detian; Wang, Zhongming; Long, Wubin; Li, Zhijun; Jiang, Gengru; Li, Xiaomei; Bi, Liqi; Jiang, Lindi; Wu, Jian; Guo, Lian; Cai, Xiaoyan; Lu, Xin; Chen, Qinkai; Chen, Hong; Peng, Ai; Zuo, Xiaoxia; Ning, Rui; Zhang, Zhe; Tai, Yanfei; Zhang, Tao; Bao, Chunde (3 November 2021). "Efficacy and safety of a selective URAT1 inhibitor SHR4640 in Chinese subjects with hyperuricaemia: a randomized controlled phase II study". Rheumatology. 60 (11): 5089–5097. doi:10.1093/rheumatology/keab198. PMID   33693494.
  4. ↑ Liang, Beibei; Wang, Jin; Bai, Nan; Zhuo, Jiaju; Wang, Rui; Lin, Hongda; Cai, Yun (April 2023). "Effect of Food on the Pharmacokinetics and Pharmacodynamics of a Single Oral Dose of SHR4640, a Selective Urate Transporter 1 Inhibitor, in Healthy Chinese Male Volunteers". Clinical Pharmacology in Drug Development. 12 (4): 392–396. doi:10.1002/cpdd.1191. ISSN   2160-7648. PMID   36317751. S2CID   253245027.
  5. ↑ "A Multicentre, Randomized, Double-blind, Allopurinol Controlled Study to Evaluate the Efficacy and Safety of SHR4640 in Subjects With Gout". www.clinicaltrials.gov. Retrieved 11 November 2023.
  6. ↑ Tang, Honghu; Cui, Beibei; Chen, Yiyu; Chen, Lin; Wang, Zhihong; Zhang, Ning; Yang, Yanlan; Wang, Xiaodong; Xie, Xiangliang; Sun, Lingyun; Dang, Wantai; Wang, Xianyang; Li, Runzi; Zou, Jianjun; Zhao, Yi; Liu, Yi (January 2022). "Safety and efficacy of SHR4640 combined with febuxostat for primary hyperuricemia: a multicenter, randomized, double-blind, phase II study". Therapeutic Advances in Musculoskeletal Disease. 14: 1759720X2110673. doi:10.1177/1759720X211067304. ISSN   1759-720X. PMC   8808016 . PMID   35126684.


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