S100P

Last updated

S100P
Protein S100P PDB 1j55.png
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases S100P , MIG9, S100 calcium binding protein P
External IDs OMIM: 600614; HomoloGene: 81743; GeneCards: S100P; OMA:S100P - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005980

n/a

RefSeq (protein)

NP_005971

n/a

Location (UCSC) Chr 4: 6.69 – 6.7 Mb n/a
PubMed search [2] n/a
Wikidata
View/Edit Human

S100 calcium-binding protein P (S100P) is a protein that in humans is encoded by the S100P gene. [3] [4] [5]

Contents

Function

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 4p16. This protein, in addition to binding Ca2+, also binds Zn2+ and Mg2+. This protein may play a role in the etiology of prostate cancer. [5]

Interactions

S100P has been shown to interact with EZR [6] and RAGE. [7] The interactions between S100P and RAGE are disrupted by cromolyn [8] and pentamidine. [7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000163993 Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Engelkamp D, Schäfer BW, Mattei MG, Erne P, Heizmann CW (Aug 1993). "Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E". Proc Natl Acad Sci U S A. 90 (14): 6547–51. Bibcode:1993PNAS...90.6547E. doi: 10.1073/pnas.90.14.6547 . PMC   46969 . PMID   8341667.
  4. Schäfer BW, Wicki R, Engelkamp D, Mattei MG, Heizmann CW (Jun 1995). "Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family". Genomics. 25 (3): 638–43. doi:10.1016/0888-7543(95)80005-7. PMID   7759097.
  5. 1 2 "Entrez Gene: S100P S100 calcium binding protein P".
  6. Koltzscher M, Neumann C, König S, Gerke V (Jun 2003). "Ca2+-dependent binding and activation of dormant ezrin by dimeric S100P". Molecular Biology of the Cell. 14 (6): 2372–84. doi:10.1091/mbc.E02-09-0553. PMC   194886 . PMID   12808036.
  7. 1 2 Penumutchu SR, Chou RH, Yu C (2014-08-01). "Structural insights into calcium-bound S100P and the V domain of the RAGE complex". PLOS ONE. 9 (8): e103947. Bibcode:2014PLoSO...9j3947P. doi: 10.1371/journal.pone.0103947 . PMC   4118983 . PMID   25084534.
  8. Penumutchu SR, Chou RH, Yu C (Oct 2014). "Interaction between S100P and the anti-allergy drug cromolyn". Biochemical and Biophysical Research Communications. 454 (3): 404–409. doi:10.1016/j.bbrc.2014.10.048. PMID   25450399.

Further reading