SARS2

For the COVID-19 virus, see Severe acute respiratory syndrome coronavirus 2.

SARS2
Identifiers
Aliases	SARS2 , SARS, SARSM, SERS, SYS, SerRS, SerRSmt, mtSerRS, seryl-tRNA synthetase 2, mitochondrial
External IDs	OMIM: 612804; MGI: 1919234; HomoloGene: 6073; GeneCards: SARS2; OMA:SARS2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q13.2 Start 38,915,266 bp [1] End 38,930,763 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7 B1|7 16.91 cM Start 28,441,417 bp [2] End 28,453,296 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart right lobe of thyroid gland right adrenal cortex left lobe of thyroid gland right lobe of liver mucosa of transverse colon left adrenal gland left adrenal cortex pituitary gland primary visual cortex Top expressed in epiblast soleus muscle Gonadal ridge yolk sac embryo muscle of thigh embryo maxillary prominence thoracic diaphragm intercostal muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function aminoacyl-tRNA ligase activity nucleotide binding ligase activity ATP binding serine-tRNA ligase activity RNA binding Cellular component cytoplasm mitochondrial matrix mitochondrion Biological process tRNA aminoacylation for protein translation protein biosynthesis seryl-tRNA aminoacylation selenocysteinyl-tRNA(Sec) biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54938 71984 Ensembl ENSG00000104835 ENSG00000283104 ENSMUSG00000070699 UniProt Q9NP81 Q9JJL8 RefSeq (mRNA) NM_017827 NM_001145901 NM_023637 RefSeq (protein) NP_001139373 NP_060297 NP_076126 Location (UCSC) Chr 19: 38.92 – 38.93 Mb Chr 7: 28.44 – 28.45 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Seryl-tRNA synthetase, mitochondrial is an enzyme that in humans is encoded by the SARS2 gene. ^{[5] [6]}

References

1. ENSG00000283104 GRCh38: Ensembl release 89: ENSG00000104835, ENSG00000283104 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000070699 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yokogawa T, Shimada N, Takeuchi N, Benkowski L, Suzuki T, Omori A, Ueda T, Nishikawa K, Spremulli LL, Watanabe K (Aug 2000). "Characterization and tRNA recognition of mammalian mitochondrial seryl-tRNA synthetase". J Biol Chem. 275 (26): 19913–20. doi: 10.1074/jbc.M908473199 . PMID   10764807.
6. "Entrez Gene: SARS2 seryl-tRNA synthetase 2, mitochondrial".

Further reading

• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
• Müller T, Deschauer M, Neudecker S, Zierz S (2007). "Late-onset mitochondrial myopathy with dystrophic changes due to a G7497A mutation in the mitochondrial tRNA(Ser(UCN)) gene". Acta Neuropathol. 110 (4): 426–30. doi:10.1007/s00401-005-1063-z. PMID   16133542. S2CID   23568019.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ihalamulla RL, Liyanage CP, Karunaweera ND (2004). "A simple device to maintain in vitro cultures of Leishmania in tropical countries". Trans. R. Soc. Trop. Med. Hyg. 98 (5): 315–7. doi:10.1016/j.trstmh.2003.10.004. PMID   15109557.
• Gibbons WJ, Yan Q, Li R, et al. (2004). "Genomic organization, expression, and subcellular localization of mouse mitochondrial seryl-tRNA synthetase". Biochem. Biophys. Res. Commun. 317 (3): 774–8. doi:10.1016/j.bbrc.2004.03.113. PMID   15081407.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Casas C, Ribera J, Esquerda JE (2001). "Antibodies against c-Jun N-terminal peptide cross-react with neo-epitopes emerging after caspase-mediated proteolysis during apoptosis". J. Neurochem. 77 (3): 904–15. doi: 10.1046/j.1471-4159.2001.00314.x . PMID   11331419. S2CID   27427659.