SC65

P3H4
Identifiers
Aliases	P3H4 , NO55, NOL55, SC65, LEPREL4, prolyl 3-hydroxylase family member 4 (non-enzymatic), prolyl 3-hydroxylase family member 4 (inactive)
External IDs	OMIM: 617419; MGI: 1913430; HomoloGene: 4713; GeneCards: P3H4; OMA:P3H4 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	41,812,604 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	100,305,662 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; periodontal fiber; ; tibia; ; ventricular zone; ; anterior pituitary; ; right lobe of thyroid gland; ; left adrenal cortex; ; tendon of biceps brachii; ; right adrenal gland; ; body of pancreas;
	Top expressed in
	calvaria; ; molar; ; epithelium of lens; ; belly cord; ; upper jaw; ; body of femur; ; supraoptic nucleus; ; vestibular membrane of cochlear duct; ; ascending aorta; ; right ventricle;
	More reference expression data
	More reference expression data
Orthologs
	10609
	66180
	ENSG00000141696
	ENSMUSG00000006931
	Q92791
	Q8K2B0
	NM_006455
	NM_176830 ; NM_001378981
	NP_006446
	NP_789800 ; NP_001365910
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 27, 2024

Endoplasmic reticulum protein SC65, also known as Leprecan-like protein 4 (LEPREL4) or nucleolar autoantigen No55, is a protein that in humans is encoded by the P3H4 gene.^[5]

Function

This nucleolar protein was first characterized because it was an autoantigen in cases on interstitial cystitis. The protein, with a predicted molecular weight of 50 kDa, appears to be localized in the particulate compartment of the interphase nucleolus, with a distribution distinct from that of nucleolar protein B23. During mitosis it is associated with chromosomes.^[5]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000141696 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006931 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "P3H4 prolyl 3-hydroxylase family member 4 (inactive) [ Homo sapiens (human) ]".

Foster LJ, Rudich A, Talior I, et al. (2006). "Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC)". J. Proteome Res. 5 (1): 64–75. doi:10.1021/pr0502626. PMID 16396496.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Fosså A, Siebert R, Aasheim HC, et al. (2000). "Identification of nucleolar protein No55 as a tumour-associated autoantigen in patients with prostate cancer". Br. J. Cancer. 83 (6): 743–9. doi:10.1054/bjoc.2000.1365. PMC 2363543 . PMID 10952778.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Ochs RL, Stein TW, Chan EK, et al. (1996). "cDNA cloning and characterization of a novel nucleolar protein". Mol. Biol. Cell. 7 (7): 1015–24. doi:10.1091/mbc.7.7.1015. PMC 275955 . PMID 8862517.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000141696 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006931 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "P3H4 prolyl 3-hydroxylase family member 4 (inactive) [ Homo sapiens (human) ]".

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SC65

Contents

Function

Related Research Articles

References

Further reading