| SCAMP1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | SCAMP1 , SCAMP, SCAMP37, secretory carrier membrane protein 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 606911 MGI: 1349480 HomoloGene: 37975 GeneCards: SCAMP1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Secretory carrier-associated membrane protein 1 is a protein that in humans is encoded by the SCAMP1 gene. [5] [6]
This gene product belongs to the SCAMP family of proteins which are secretory carrier membrane proteins. They function as carriers to the cell surface in post-golgi recycling pathways. Different family members are highly related products of distinct genes, and are usually expressed together. These findings suggest that the SCAMPs may function at the same site during vesicular transport rather than in separate pathways. [6]
SCAMP1 has been shown to interact with ITSN1 [7] and AP1GBP1. [7]
ADP-ribosylation factor 6 (ARF6) is a member of the ADP ribosylation factor family of GTP-binding proteins. ARF6 has a variety of cellular functions that are frequently involved in trafficking of biological membranes and transmembrane protein cargo. ARF6 has specifically been implicated in endocytosis of plasma membrane proteins and also, to a lesser extent, plasma membrane protein recycling.
Syntaxin-1A is a protein that in humans is encoded by the STX1A gene.
Synaptosomal-associated protein 23 is a protein that in humans is encoded by the SNAP23 gene. Two alternative transcript variants encoding different protein isoforms have been described for this gene.
Syntaxin-4 is a protein that in humans is encoded by the STX4 gene.
Intersectin-1 is a protein that, in humans, is encoded by the ITSN1 gene.
Synaptotagmin-1 is a protein that in humans is encoded by the SYT1 gene.
Vesicle-associated membrane protein 2 (VAMP2) is a protein that in humans is encoded by the VAMP2 gene.
Syntaxin-2, also known as epimorphin, is a protein that in humans is encoded by the STX2 gene.
Golgin subfamily A member 4 is a protein that in humans is encoded by the GOLGA4 gene.
Syntaxin-binding protein 2 is a protein that in humans is encoded by the STXBP2 gene.
Synergin gamma also known as AP1 subunit gamma-binding protein 1 (AP1GBP1) is a protein that in humans is encoded by the SYNRG gene.
DnaJ homolog subfamily C member 5, also known as cysteine string protein or CSP is a protein, that in humans encoded by the DNAJC5 gene. It was first described in 1990.
Vesicle-trafficking protein SEC22b is a protein that in humans is encoded by the SEC22B gene.
Secretory carrier-associated membrane protein 2 is a protein that in humans is encoded by the SCAMP2 gene.
Secretory carrier-associated membrane protein 3 is a protein that in humans is encoded by the SCAMP3 gene.
Protein transport protein Sec61 subunit gamma is a protein that in humans is encoded by the SEC61G gene.
Secretory carrier-associated membrane protein 5 is a protein that in humans is encoded by the SCAMP5 gene.
Ras-related protein Rab-27A is a protein that in humans is encoded by the RAB27A gene.
Syntaxin 3, also known as STX3, is a protein which in humans is encoded by the STX3 gene.
Giantin or Golgin subfamily B member 1 is a protein that in humans is encoded by the GOLGB1 gene. Giantin is located at the cis-medial rims of the Golgi apparatus and is part of the Golgi matrix that is responsible for membrane trafficking in secretory pathway of proteins. This function is key for proper localisation of proteins at the plasma membrane and outside the cell which is important for cell function that is dependent on for example receptors and the extracellular matrix function. Recent animal model knockout studies of GOLGB1 in mice, rat, and zebrafish have shown that phenotypes are different between species ranging from mild to severe craniofacial defects in the rodent models to just minor size defects in zebrafish. However, in adult zebrafish a tumoral calcinosis-like phenotype was observed, and in humans such phenotype has been linked to defective glycosyltransferase function.
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