SCAMP3

SCAMP3
Identifiers
Aliases	SCAMP3 , C1orf3, secretory carrier membrane protein 3
External IDs	OMIM: 606913 MGI: 1346346 HomoloGene: 4164 GeneCards: SCAMP3
Gene location (Human)
Chr.	Chromosome 1 (human)
End	155,262,430 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	89,090,072 bp
RNA expression pattern
	Top expressed in
	Left adrenal gland; ; stromal cell of endometrium; ; left ventricle; ; skin of abdomen; ; gastrocnemius muscle; ; spleen; ; body of pancreas; ; placenta; ; body of stomach; ; lymph node;
	Top expressed in
	yolk sac; ; external carotid artery; ; mirror; ; proximal tubule; ; lip; ; internal carotid artery; ; superior frontal gyrus; ; secondary oocyte; ; left lobe of liver; ; thymus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ubiquitin protein ligase binding ;
Cellular component	integral component of membrane ; extracellular exosome ; intracellular membrane-bounded organelle ; membrane ; Golgi membrane ; Golgi apparatus ; trans-Golgi network membrane ; recycling endosome membrane ;
Biological process	protein transport ; post-Golgi vesicle-mediated transport ; transport ;
	Sources:Amigo / QuickGO
Orthologs
	10067
	24045
	ENSG00000263290 ; ENSG00000116521
	ENSMUSG00000028049
	O14828
	O35609
	NM_005698 ; NM_052837
	NM_011886 ; NM_001309909 ; NM_001309910
	NP_005689 ; NP_443069
	NP_001296838 ; NP_001296839 ; NP_036016
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 12, 2022

Secretory carrier-associated membrane protein 3 is a protein that in humans is encoded by the SCAMP3 gene.^[5]^[6]^[7]

Function

This gene product belongs to the SCAMP family of proteins which are secretory carrier membrane proteins. They function as carriers to the cell surface in post-golgi recycling pathways. Different family members are highly related products of distinct genes, and are usually expressed together. These findings suggest that the SCAMPs may function at the same site during vesicular transport rather than in separate pathways. Two transcript variants encoding different isoforms have been found for this gene.^[7]

Interactions

SCAMP3 has been shown to interact with NEDD4.^[8]

Related Research Articles

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References

1 2 3 ENSG00000116521 GRCh38: Ensembl release 89: ENSG00000263290, ENSG00000116521 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028049 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Winfield SL, Tayebi N, Martin BM, Ginns EI, Sidransky E (October 1997). "Identification of three additional genes contiguous to the glucocerebrosidase locus on chromosome 1q21: implications for Gaucher disease". Genome Research. 7 (10): 1020–6. doi:10.1101/gr.7.10.1020. PMC 310674 . PMID 9331372.
↑ Wu TT, Castle JD (July 1998). "Tyrosine phosphorylation of selected secretory carrier membrane proteins, SCAMP1 and SCAMP3, and association with the EGF receptor". Molecular Biology of the Cell. 9 (7): 1661–74. doi:10.1091/mbc.9.7.1661. PMC 25404 . PMID 9658162.
1 2 "Entrez Gene: SCAMP3 secretory carrier membrane protein 3".
↑ Aoh QL, Castle AM, Hubbard CH, Katsumata O, Castle JD (March 2009). "SCAMP3 negatively regulates epidermal growth factor receptor degradation and promotes receptor recycling". Molecular Biology of the Cell. 20 (6): 1816–32. doi:10.1091/mbc.E08-09-0894. PMC 2655259 . PMID 19158374.

External links

SCAMP3 human gene location in the UCSC Genome Browser .
SCAMP3 human gene details in the UCSC Genome Browser .

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000116521 GRCh38: Ensembl release 89: ENSG00000263290, ENSG00000116521 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028049 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9331372-5] Winfield SL, Tayebi N, Martin BM, Ginns EI, Sidransky E (October 1997). "Identification of three additional genes contiguous to the glucocerebrosidase locus on chromosome 1q21: implications for Gaucher disease". Genome Research. 7 (10): 1020–6. doi:10.1101/gr.7.10.1020. PMC 310674 . PMID 9331372.

[pmid9658162-6] Wu TT, Castle JD (July 1998). "Tyrosine phosphorylation of selected secretory carrier membrane proteins, SCAMP1 and SCAMP3, and association with the EGF receptor". Molecular Biology of the Cell. 9 (7): 1661–74. doi:10.1091/mbc.9.7.1661. PMC 25404 . PMID 9658162.

[entrez-7] 1 2 "Entrez Gene: SCAMP3 secretory carrier membrane protein 3".

[pmid19158374-8] Aoh QL, Castle AM, Hubbard CH, Katsumata O, Castle JD (March 2009). "SCAMP3 negatively regulates epidermal growth factor receptor degradation and promotes receptor recycling". Molecular Biology of the Cell. 20 (6): 1816–32. doi:10.1091/mbc.E08-09-0894. PMC 2655259 . PMID 19158374.

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