SCPEP1

SCPEP1
Identifiers
Aliases	SCPEP1 , HSCP1, RISC, serine carboxypeptidase 1
External IDs	MGI: 1921867 HomoloGene: 41443 GeneCards: SCPEP1
Gene location (Human)
Chr.	Chromosome 17 (human)
End	57,006,768 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	88,846,291 bp
RNA expression pattern
	Top expressed in
	monocyte; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; gallbladder; ; ascending aorta; ; right coronary artery; ; gastric mucosa; ; minor salivary gland; ; right lung; ; skin of abdomen;
	Top expressed in
	calvaria; ; pineal gland; ; external carotid artery; ; internal carotid artery; ; iris; ; skin of abdomen; ; carotid body; ; intercostal muscle; ; vas deferens; ; cervix;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	carboxypeptidase activity ; peptidase activity ; hydrolase activity ; serine-type carboxypeptidase activity ;
Cellular component	extracellular region ; cytosol ; extracellular exosome ;
Biological process	proteolysis involved in cellular protein catabolic process ; retinoic acid metabolic process ; negative regulation of blood pressure ; proteolysis ;
	Sources:Amigo / QuickGO
Orthologs
	59342
	74617
	ENSG00000121064
	ENSMUSG00000000278
	Q9HB40
	Q920A5
	NM_021626
	NM_029023
	NP_067639
	NP_083299
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 22, 2022

Retinoid-inducible serine carboxypeptidase is an enzyme that in humans is encoded by the SCPEP1 gene.^[5]^[6]^[7]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000121064 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000000278 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Chen J, Streb JW, Maltby KM, Kitchen CM, Miano JM (Sep 2001). "Cloning of a novel retinoid-inducible serine carboxypeptidase from vascular smooth muscle cells". J Biol Chem. 276 (36): 34175–81. doi: 10.1074/jbc.M104162200 . PMID 11447226.
↑ Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (Oct 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697 . PMID 12975309.
↑ "Entrez Gene: SCPEP1 serine carboxypeptidase 1".

Robb GB, Rana TM (2007). "RNA helicase A interacts with RISC in human cells and functions in RISC loading". Mol. Cell. 26 (4): 523–37. doi: 10.1016/j.molcel.2007.04.016 . PMID 17531811.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551 . PMID 15340161.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry". Nat. Biotechnol. 21 (6): 660–6. doi:10.1038/nbt827. PMID 12754519. S2CID 581283.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000121064 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000000278 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11447226-5] Chen J, Streb JW, Maltby KM, Kitchen CM, Miano JM (Sep 2001). "Cloning of a novel retinoid-inducible serine carboxypeptidase from vascular smooth muscle cells". J Biol Chem. 276 (36): 34175–81. doi: 10.1074/jbc.M104162200 . PMID 11447226.

[pmid12975309-6] Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (Oct 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697 . PMID 12975309.

[entrez-7] "Entrez Gene: SCPEP1 serine carboxypeptidase 1".

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SCPEP1

Related Research Articles

References

Further reading