SCPEP1

SCPEP1
Identifiers
Aliases	SCPEP1 , HSCP1, RISC, serine carboxypeptidase 1
External IDs	MGI: 1921867; HomoloGene: 41443; GeneCards: SCPEP1; OMA:SCPEP1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q22 Start 56,978,129 bp [1] End 57,006,768 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 C Start 88,814,846 bp [2] End 88,846,291 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal cortex monocyte left adrenal cortex olfactory zone of nasal mucosa left lobe of thyroid gland right lobe of thyroid gland Descending thoracic aorta gallbladder ascending aorta right coronary artery Top expressed in decidua Gonadal ridge gastrula calvaria pineal gland external carotid artery efferent ductule internal carotid artery iris skin of abdomen More reference expression data BioGPS More reference expression data
Gene ontology Molecular function carboxypeptidase activity peptidase activity hydrolase activity serine-type carboxypeptidase activity Cellular component extracellular region cytosol extracellular exosome Biological process proteolysis involved in cellular protein catabolic process retinoic acid metabolic process negative regulation of blood pressure proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 59342 74617 Ensembl ENSG00000121064 ENSMUSG00000000278 UniProt Q9HB40 Q920A5 RefSeq (mRNA) NM_021626 NM_029023 RefSeq (protein) NP_067639 NP_083299 Location (UCSC) Chr 17: 56.98 – 57.01 Mb Chr 11: 88.81 – 88.85 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Retinoid-inducible serine carboxypeptidase is an enzyme that in humans is encoded by the SCPEP1 gene. ^{[5] [6] [7]}

See also

• Carboxypeptidase
  • Serine carboxypeptidase
• Retinoid

References

1. GRCh38: Ensembl release 89: ENSG00000121064 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000000278 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chen J, Streb JW, Maltby KM, Kitchen CM, Miano JM (September 2001). "Cloning of a novel retinoid-inducible serine carboxypeptidase from vascular smooth muscle cells". The Journal of Biological Chemistry. 276 (36): 34175–34181. doi: 10.1074/jbc.M104162200 . PMID   11447226.
6. Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, et al. (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–2270. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
7. "Entrez Gene: SCPEP1 serine carboxypeptidase 1".

Further reading

• Robb GB, Rana TM (May 2007). "RNA helicase A interacts with RISC in human cells and functions in RISC loading". Molecular Cell. 26 (4): 523–537. doi: 10.1016/j.molcel.2007.04.016 . PMID   17531811.
• Zhang Z, Henzel WJ (October 2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Science. 13 (10): 2819–2824. doi:10.1110/ps.04682504. PMC   2286551 . PMID   15340161.
• Zhang H, Li XJ, Martin DB, Aebersold R (June 2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry". Nature Biotechnology. 21 (6): 660–666. doi:10.1038/nbt827. PMID   12754519. S2CID   581283.