SCYL2

SCYL2
Identifiers
Aliases	SCYL2 , CVAK104, SCY1 like pseudokinase 2, AMCNACC, AMC4
External IDs	OMIM: 616365 MGI: 1289172 HomoloGene: 13349 GeneCards: SCYL2
Gene location (Human)
Chr.	Chromosome 12 (human)
End	100,341,715 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	89,522,147 bp
RNA expression pattern
	Top expressed in
	corpus epididymis; ; secondary oocyte; ; jejunal mucosa; ; palpebral conjunctiva; ; amniotic fluid; ; cavity of mouth; ; rectum; ; monocyte; ; endothelial cell; ; ganglionic eminence;
	Top expressed in
	secondary oocyte; ; hand; ; superior cervical ganglion; ; endocardial cushion; ; urothelium; ; medullary collecting duct; ; atrioventricular valve; ; spermatocyte; ; supraoptic nucleus; ; ureter;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ATP binding ; signaling receptor binding ; protein kinase activity ; protein binding ;
Cellular component	Golgi apparatus ; endosome membrane ; membrane ; cytoplasmic vesicle ; clathrin-coated vesicle ; cytoplasm ; endosome ; perinuclear region of cytoplasm ;
Biological process	receptor internalization involved in canonical Wnt signaling pathway ; negative regulation of canonical Wnt signaling pathway ; protein phosphorylation ; endosome to lysosome transport ; positive regulation of clathrin-dependent endocytosis ; positive regulation of receptor internalization ;
	Sources:Amigo / QuickGO
Orthologs
	55681
	213326
	ENSG00000136021
	ENSMUSG00000069539
	Q6P3W7
	Q8CFE4
	NM_017988 ; NM_001317784 ; NM_001330253 ; NM_001330254 ; NM_001330256
	NM_198021 ; NM_001310704 ; NM_001358843
	NP_001304713 ; NP_001317182 ; NP_001317183 ; NP_001317185 ; NP_060458
	NP_001297633 ; NP_932138 ; NP_001345772
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated January 20, 2023

SCY1-like protein 2 is a protein that in humans is encoded by the SCYL2 gene.^[5]^[6]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000136021 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000069539 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O (Apr 2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi: 10.1093/dnares/7.1.65 . PMID 10718198.
↑ "Entrez Gene: SCYL2 SCY1-like 2 (S. cerevisiae)".

Borner GH, Rana AA, Forster R, et al. (2007). "CVAK104 is a Novel Regulator of Clathrin-mediated SNARE Sorting". Traffic. 8 (7): 893–903. doi:10.1111/j.1600-0854.2007.00576.x. PMC 2239300 . PMID 17587408.
Düwel M, Ungewickell EJ (2007). "Clathrin-dependent Association of CVAK104 with Endosomes and the Trans-Golgi Network". Mol. Biol. Cell. 17 (10): 4513–25. doi:10.1091/mbc.E06-05-0390. PMC 1635376 . PMID 16914521.
Schmid EM, Ford MG, Burtey A, et al. (2007). "Role of the AP2 β-Appendage Hub in Recruiting Partners for Clathrin-Coated Vesicle Assembly". PLOS Biol. 4 (9): e262. doi:10.1371/journal.pbio.0040262. PMC 1540706 . PMID 16903783.
Conner SD, Schmid SL (2005). "CVAK104 is a novel poly-L-lysine-stimulated kinase that targets the beta2-subunit of AP2". J. Biol. Chem. 280 (22): 21539–44. doi: 10.1074/jbc.M502462200 . PMID 15809293.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000136021 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000069539 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10718198-5] Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O (Apr 2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi: 10.1093/dnares/7.1.65 . PMID 10718198.

[entrez-6] "Entrez Gene: SCYL2 SCY1-like 2 (S. cerevisiae)".

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SCYL2

Related Research Articles

References

Further reading