SEC13

SEC13
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3BG0, 3BG1, 5A9Q
Identifiers
Aliases	SEC13 , D3S1231E, SEC13L1, SEC13R, npp-20, SEC13 homolog, nuclear pore and COPII coat complex component
External IDs	OMIM: 600152 MGI: 99832 HomoloGene: 6479 GeneCards: SEC13
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3p25.3 Start 10,293,131 bp [1] End 10,321,112 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6 E3|6 52.84 cM Start 113,705,023 bp [2] End 113,717,704 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium oocyte pituitary gland anterior pituitary duodenum jejunal mucosa parotid gland tibia smooth muscle tissue secondary oocyte Top expressed in molar seminal vesicula otic placode maxillary prominence endocardial cushion neural tube duodenum hand calvaria abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding identical protein binding structural molecule activity Cellular component endoplasmic reticulum membrane intracellular membrane-bounded organelle membrane nuclear envelope nuclear pore nucleoplasm GATOR2 complex nuclear pore outer ring endoplasmic reticulum ER to Golgi transport vesicle membrane extracellular exosome cytoplasmic vesicle nucleus kinetochore Golgi membrane lysosome lysosomal membrane COPII vesicle coat cytosol host cell Biological process mRNA transport antigen processing and presentation of exogenous peptide antigen via MHC class II antigen processing and presentation of peptide antigen via MHC class I COPII vesicle coating protein transport intracellular protein transport vesicle-mediated transport positive regulation of TOR signaling sister chromatid cohesion COPII-coated vesicle cargo loading transport protein exit from endoplasmic reticulum COPII-coated vesicle budding positive regulation of TORC1 signaling regulation of glycolytic process mRNA export from nucleus tRNA export from nucleus viral process viral transcription regulation of gene silencing by miRNA intracellular transport of virus regulation of cellular response to heat Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6396 110379 Ensembl ENSG00000157020 ENSMUSG00000030298 UniProt P55735 Q9D1M0 RefSeq (mRNA) NM_001136026 NM_001136232 NM_001278946 NM_030673 NM_183352 NM_024206 RefSeq (protein) NP_001129498 NP_001129704 NP_001265875 NP_109598 NP_899195 NP_077168 Location (UCSC) Chr 3: 10.29 – 10.32 Mb Chr 6: 113.71 – 113.72 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein SEC13 homolog is a protein that in humans is encoded by the SEC13 gene. ^{[5] [6]}

The protein encoded by this gene belongs to the SEC13 family of WD-repeat proteins. It has similarity to the yeast SEC13 and SEC31 proteins, which are required for vesicle biogenesis from the endoplasmic reticulum during the transport of proteins. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000157020 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030298 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Swaroop A, Yang-Feng TL, Liu W, Gieser L, Barrow LL, Chen KC, Agarwal N, Meisler MH, Smith DI (Jan 1995). "Molecular characterization of a novel human gene, SEC13R, related to the yeast secretory pathway gene SEC13, and mapping to a conserved linkage group on human chromosome 3p24-p25 and mouse chromosome 6". Hum Mol Genet. 3 (8): 1281–6. doi:10.1093/hmg/3.8.1281. PMID   7987303.
6. "Entrez Gene: SEC13 SEC13 homolog (S. cerevisiae)".

Further reading

• Shaywitz DA, Orci L, Ravazzola M, et al. (1995). "Human SEC13Rp functions in yeast and is located on transport vesicles budding from the endoplasmic reticulum". J. Cell Biol. 128 (5): 769–77. doi:10.1083/jcb.128.5.769. PMC   2120388 . PMID   7876304.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Mammoto A, Sasaki T, Kim Y, Takai Y (2000). "Physical and functional interaction of rabphilin-11 with mammalian Sec13 protein. Implication in vesicle trafficking". J. Biol. Chem. 275 (18): 13167–70. doi: 10.1074/jbc.C000096200 . PMID   10747849.
• Tang BL, Zhang T, Low DY, et al. (2000). "Mammalian homologues of yeast sec31p. An ubiquitously expressed form is localized to endoplasmic reticulum (ER) exit sites and is essential for ER-Golgi transport". J. Biol. Chem. 275 (18): 13597–604. doi: 10.1074/jbc.275.18.13597 . PMID   10788476.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID   12665801. S2CID   23783563.
• Enninga J, Levay A, Fontoura BM (2003). "Sec13 shuttles between the nucleus and the cytoplasm and stably interacts with Nup96 at the nuclear pore complex". Mol. Cell. Biol. 23 (20): 7271–84. doi:10.1128/MCB.23.20.7271-7284.2003. PMC   230331 . PMID   14517296.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID   14743216. S2CID   11683986.
• Loïodice I, Alves A, Rabut G, et al. (2005). "The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis". Mol. Biol. Cell. 15 (7): 3333–44. doi:10.1091/mbc.E03-12-0878. PMC   452587 . PMID   15146057.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Stagg SM, Gürkan C, Fowler DM, et al. (2006). "Structure of the Sec13/31 COPII coat cage". Nature. 439 (7073): 234–8. Bibcode:2006Natur.439..234S. doi:10.1038/nature04339. PMID   16407955. S2CID   2426465.