SEC16A

SEC16A
Identifiers
Aliases	SEC16A , KIAA0310, SEC16L, p250, SEC16 homolog A, endoplasmic reticulum export factor
External IDs	OMIM: 612854; MGI: 2139207; HomoloGene: 10533; GeneCards: SEC16A; OMA:SEC16A - orthologs
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9q34.3 Start 136,440,096 bp [1] End 136,483,759 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 A3 Start 26,299,443 bp [2] End 26,335,228 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in anterior pituitary right lobe of liver cardia pylorus body of stomach right hemisphere of cerebellum body of pancreas fundus nasal epithelium mucosa of transverse colon Top expressed in zygote parotid gland lacrimal gland submandibular gland molar pituitary gland tail of embryo genital tubercle lobe of prostate secondary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytosol Golgi membrane Golgi apparatus endoplasmic reticulum membrane membrane endoplasmic reticulum cytoplasm ER to Golgi transport vesicle membrane organelle membrane intracellular membrane-bounded organelle perinuclear region of cytoplasm endoplasmic reticulum exit site Biological process protein transport COPII vesicle coating substantia nigra development vesicle-mediated transport endoplasmic reticulum organization transport endoplasmic reticulum to Golgi vesicle-mediated transport Golgi organization protein exit from endoplasmic reticulum response to endoplasmic reticulum stress Golgi to plasma membrane CFTR protein transport protein stabilization positive regulation of protein exit from endoplasmic reticulum protein localization to endoplasmic reticulum exit site protein localization to plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9919 227648 Ensembl ENSG00000148396 ENSMUSG00000026924 UniProt O15027 E9QAT4 RefSeq (mRNA) NM_001276418 NM_014866 NM_153125 RefSeq (protein) NP_001263347 NP_055681 NP_694765 Location (UCSC) Chr 9: 136.44 – 136.48 Mb Chr 2: 26.3 – 26.34 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein transport protein Sec16A is a protein that in humans is encoded by the SEC16A gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000148396 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026924 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (April 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 4 (2): 141–50. doi: 10.1093/dnares/4.2.141 . PMID   9205841.
6. "Entrez Gene: KIAA0310 KIAA0310".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (June 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. CiteSeerX   10.1.1.500.923 . doi:10.1093/dnares/9.3.99. PMID   12168954.
• Iinuma T, Shiga A, Nakamoto K, O'Brien MB, Aridor M, Arimitsu N, Tagaya M, Tani K (June 2007). "Mammalian Sec16/p250 plays a role in membrane traffic from the endoplasmic reticulum". The Journal of Biological Chemistry. 282 (24): 17632–9. doi: 10.1074/jbc.M611237200 . PMID   17428803.
• Bhattacharyya D, Glick BS (March 2007). "Two mammalian Sec16 homologues have nonredundant functions in endoplasmic reticulum (ER) export and transitional ER organization". Molecular Biology of the Cell. 18 (3): 839–49. doi:10.1091/mbc.E06-08-0707. PMC   1805085 . PMID   17192411.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Watson P, Townley AK, Koka P, Palmer KJ, Stephens DJ (December 2006). "Sec16 defines endoplasmic reticulum exit sites and is required for secretory cargo export in mammalian cells". Traffic. 7 (12): 1678–87. doi:10.1111/j.1600-0854.2006.00493.x. PMC   1761133 . PMID   17005010.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (February 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97–105. doi:10.1038/ncb1086. PMID   14743216. S2CID   11683986.
• Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.