SEC61B

SEC61B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2WWB, 4CG6
Identifiers
Aliases	SEC61B , Sec61 translocon beta subunit, SEC61 translocon subunit beta
External IDs	OMIM: 609214; MGI: 1913462; HomoloGene: 38229; GeneCards: SEC61B; OMA:SEC61B - orthologs
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9q22.33 Start 99,222,064 bp [1] End 99,230,615 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 B1 Start 47,474,658 bp [2] End 47,483,242 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland body of pancreas oocyte corpus epididymis pylorus anterior pituitary trachea olfactory zone of nasal mucosa beta cell right lobe of liver Top expressed in parotid gland seminal vesicula submandibular gland gastrula islet of Langerhans mandibular prominence molar maxillary prominence somite lacrimal gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function epidermal growth factor binding protein binding RNA binding protein-transporting ATPase activity Cellular component integral component of membrane cytosol membrane Sec61 endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum Sec complex Biological process retrograde protein transport, ER to cytosol IRE1-mediated unfolded protein response ubiquitin-dependent ERAD pathway protein transport intracellular protein transport SRP-dependent cotranslational protein targeting to membrane, translocation posttranslational protein targeting to membrane, translocation transport regulation of molecular function Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10952 66212 Ensembl ENSG00000106803 ENSMUSG00000053317 UniProt P60468 Q9CQS8 RefSeq (mRNA) NM_006808 NM_024171 RefSeq (protein) NP_006799 NP_077133 Location (UCSC) Chr 9: 99.22 – 99.23 Mb Chr 4: 47.47 – 47.48 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein transport protein Sec61 subunit beta is a protein that in humans is encoded by the SEC61B gene. ^{[5] [6] [7]}

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The Sec61 complex forms a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000106803 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000053317 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hartmann E, Sommer T, Prehn S, Gorlich D, Jentsch S, Rapoport TA (Mar 1994). "Evolutionary conservation of components of the protein translocation complex". Nature. 367 (6464): 654–7. Bibcode:1994Natur.367..654H. doi:10.1038/367654a0. PMID   8107851. S2CID   4323463.
6. Greenfield JJ, High S (Aug 1999). "The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment". J Cell Sci. 112 (10): 1477–86. doi:10.1242/jcs.112.10.1477. PMID   10212142.
7. "Entrez Gene: SEC61B Sec61 beta subunit".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Wiertz EJ, Tortorella D, Bogyo M, et al. (1997). "Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction". Nature. 384 (6608): 432–8. doi:10.1038/384432a0. PMID   8945469. S2CID   6276718.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Knight BC, High S (1998). "Membrane integration of Sec61alpha: a core component of the endoplasmic reticulum translocation complex". Biochem. J. 331 (Pt 1): 161–7. doi:10.1042/bj3310161. PMC   1219334 . PMID   9512475.
• Chen Y, Le Cahérec F, Chuck SL (1998). "Calnexin and other factors that alter translocation affect the rapid binding of ubiquitin to apoB in the Sec61 complex". J. Biol. Chem. 273 (19): 11887–94. doi: 10.1074/jbc.273.19.11887 . PMID   9565615.
• Kalies KU, Rapoport TA, Hartmann E (1998). "The β Subunit of the Sec61 Complex Facilitates Cotranslational Protein Transport and Interacts with the Signal Peptidase during Translocation". J. Cell Biol. 141 (4): 887–94. doi:10.1083/jcb.141.4.887. PMC   2132780 . PMID   9585408.
• Bebök Z, Mazzochi C, King SA, et al. (1998). "The mechanism underlying cystic fibrosis transmembrane conductance regulator transport from the endoplasmic reticulum to the proteasome includes Sec61beta and a cytosolic, deglycosylated intermediary". J. Biol. Chem. 273 (45): 29873–8. doi: 10.1074/jbc.273.45.29873 . PMID   9792704.
• Ingley E, Williams JH, Walker CE, et al. (1999). "A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit". FEBS Lett. 459 (1): 69–74. doi:10.1016/S0014-5793(99)01188-6. PMID   10508919. S2CID   30948975.
• Yamaguchi A, Hori O, Stern DM, et al. (2000). "Stress-Associated Endoplasmic Reticulum Protein 1 (Serp1)/Ribosome-Associated Membrane Protein 4 (Ramp4) Stabilizes Membrane Proteins during Stress and Facilitates Subsequent Glycosylation". J. Cell Biol. 147 (6): 1195–204. doi:10.1083/jcb.147.6.1195. PMC   2168098 . PMID   10601334.
• Meyer HA, Grau H, Kraft R, et al. (2000). "Mammalian Sec61 is associated with Sec62 and Sec63". J. Biol. Chem. 275 (19): 14550–7. doi: 10.1074/jbc.275.19.14550 . PMID   10799540.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC   2734081 . PMID   15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Besemer J, Harant H, Wang S, et al. (2005). "Selective inhibition of cotranslational translocation of vascular cell adhesion molecule 1". Nature. 436 (7048): 290–3. Bibcode:2005Natur.436..290B. doi:10.1038/nature03670. PMID   16015337. S2CID   4431610.
• Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID   16083285.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Liao HJ, Carpenter G (2007). "Role of the Sec61 Translocon in EGF Receptor Trafficking to the Nucleus and Gene Expression". Mol. Biol. Cell. 18 (3): 1064–72. doi:10.1091/mbc.E06-09-0802. PMC   1805100 . PMID   17215517.