SEMA4G

Last updated
SEMA4G
Identifiers
Aliases SEMA4G , semaphorin 4G
External IDs MGI: 1347047; HomoloGene: 22682; GeneCards: SEMA4G; OMA:SEMA4G - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001203244
NM_017893

NM_011976

RefSeq (protein)

NP_001190173
NP_060363

NP_036106

Location (UCSC) Chr 10: 100.97 – 100.99 Mb Chr 19: 44.99 – 45 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Semaphorin-4G is a protein in humans encoded by the SEMA4G gene. [5]

Semaphorins are a large family of conserved, secreted and membrane associated proteins which possess a semaphoring (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Semaphorins maintain cell motility and attachment in axon guidance, immune cell maintenance, vascular growth and tumour movement. [6]

Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. This gene encodes a class 4 semaphorin. This gene and the gene for mitochondrial ribosomal protein L43 overlap at map location 10q24.31 and are transcribed in opposite directions. [5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000095539 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025207 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G".
  6. Kruger, Robert P.; Aurandt, Jennifer; Guan, Kun-Liang (October 2005). "Semaphorins command cells to move" . Nature Reviews Molecular Cell Biology. 6 (10): 789–800. doi:10.1038/nrm1740. ISSN   1471-0080.

Further reading