SEMA4G

SEMA4G
Identifiers
Aliases	SEMA4G , semaphorin 4G
External IDs	MGI: 1347047; HomoloGene: 22682; GeneCards: SEMA4G; OMA:SEMA4G - orthologs
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q24.31 Start 100,969,518 bp [1] End 100,985,871 bp [1]
Gene location (Mouse) Chr. Chromosome 19 (mouse) [2] Band 19|19 C3 Start 44,989,101 bp [2] End 45,003,397 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon rectum right lobe of liver mucosa of ileum right hemisphere of cerebellum body of pancreas right ovary left ovary right lobe of thyroid gland skin of leg Top expressed in left lobe of liver crypt of lieberkuhn of small intestine epithelium of small intestine colon left colon duodenum right lobe of liver jejunum cerebellar cortex ileum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding neuropilin binding semaphorin receptor binding chemorepellent activity Cellular component integral component of membrane plasma membrane membrane extracellular space integral component of plasma membrane Biological process multicellular organism development cell differentiation nervous system development negative chemotaxis neural crest cell migration positive regulation of cell migration negative regulation of axon extension involved in axon guidance semaphorin-plexin signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57715 26456 Ensembl ENSG00000095539 ENSMUSG00000025207 UniProt Q9NTN9 Q9WUH7 RefSeq (mRNA) NM_001203244 NM_017893 NM_011976 RefSeq (protein) NP_001190173 NP_060363 NP_036106 Location (UCSC) Chr 10: 100.97 – 100.99 Mb Chr 19: 44.99 – 45 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Semaphorin-4G is a protein in humans encoded by the SEMA4G gene. ^[5]

Semaphorins are a large family of conserved, secreted and membrane associated proteins which possess a semaphoring (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Semaphorins maintain cell motility and attachment in axon guidance, immune cell maintenance, vascular growth and tumour movement. ^[6]

Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. This gene encodes a class 4 semaphorin. This gene and the gene for mitochondrial ribosomal protein L43 overlap at map location 10q24.31 and are transcribed in opposite directions. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000095539 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025207 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G".
6. Kruger, Robert P.; Aurandt, Jennifer; Guan, Kun-Liang (October 2005). "Semaphorins command cells to move". Nature Reviews Molecular Cell Biology. 6 (10): 789–800. doi:10.1038/nrm1740. ISSN   1471-0080.

Further reading

• Pasterkamp RJ, Kolodkin AL (2003). "Semaphorin junction: making tracks toward neural connectivity". Curr. Opin. Neurobiol. 13 (1): 79–89. doi:10.1016/S0959-4388(03)00003-5. PMID   12593985. S2CID   40661992.
• Dickson BJ (2003). "Molecular mechanisms of axon guidance". Science. 298 (5600): 1959–64. doi:10.1126/science.1072165. PMID   12471249. S2CID   28328792.
• Holtmaat AJ, De Winter F, De Wit J, et al. (2002). "Semaphorins: Contributors to structural stability of hippocampal networks?". Plasticity in the Adult Brain: From Genes to Neurotherapy. Progress in Brain Research. Vol. 138. pp. 17–38. doi:10.1016/S0079-6123(02)38068-3. ISBN   978-0-444-50981-9. PMID   12432760.{{cite book}}: |journal= ignored (help)
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi: 10.1038/nature02462 . PMID   15164054.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Nagase T, Kikuno R, Nakayama M, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. doi: 10.1093/dnares/7.4.271 . PMID   10997877.