SEMA5A

Last updated
SEMA5A
Identifiers
Aliases SEMA5A , SEMAF, semF, semaphorin 5A
External IDs OMIM: 609297; MGI: 107556; HomoloGene: 2949; GeneCards: SEMA5A; OMA:SEMA5A - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003966

NM_009154

RefSeq (protein)

NP_003957

NP_033180

Location (UCSC) Chr 5: 9.04 – 9.55 Mb Chr 15: 32.24 – 32.7 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Semaphorin-5A is a protein that in humans is encoded by the SEMA5A gene. [5] [6] [7]

Members of the semaphorin protein family, such as SEMA5A, are involved in axonal guidance during neural development. [7] [5]

Semaphorin 5A also plays a role in autism, reducing the ability of neurons to form connections with other neurons in certain brain regions. [8] [9]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000112902 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022231 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 Adams RH, Betz H, Püschel AW (June 1996). "A novel class of murine semaphorins with homology to thrombospondin is differentially expressed during early embryogenesis". Mechanisms of Development. 57 (1): 33–45. doi: 10.1016/0925-4773(96)00525-4 . PMID   8817451. S2CID   17827262.
  6. Simmons AD, Püschel AW, McPherson JD, Overhauser J, Lovett M (January 1998). "Molecular cloning and mapping of human semaphorin F from the Cri-du-chat candidate interval". Biochemical and Biophysical Research Communications. 242 (3): 685–691. doi:10.1006/bbrc.1997.8027. PMID   9464278.
  7. 1 2 "Entrez Gene: SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A".
  8. Mosca-Boidron AL, Gueneau L, Huguet G, Goldenberg A, Henry C, Gigot N, et al. (June 2016). "A de novo microdeletion of SEMA5A in a boy with autism spectrum disorder and intellectual disability". European Journal of Human Genetics. 24 (6): 838–843. doi:10.1038/ejhg.2015.211. PMC   4867450 . PMID   26395558.
  9. Carulli D, de Winter F, Verhaagen J (2021). "Semaphorins in Adult Nervous System Plasticity and Disease". Frontiers in Synaptic Neuroscience. 13: 672891. doi: 10.3389/fnsyn.2021.672891 . PMC   8148045 . PMID   34045951.

Further reading