SENP7

SENP7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3EAY
Identifiers
Aliases	SENP7 , SUMO1/sentrin specific peptidase 7, SUMO specific peptidase 7
External IDs	OMIM: 612846; MGI: 1913565; HomoloGene: 10778; GeneCards: SENP7; OMA:SENP7 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3q12.3 Start 101,324,205 bp [1] End 101,513,241 bp [1]
Gene location (Mouse) Chr. Chromosome 16 (mouse) [2] Band 16|16 C1.1 Start 55,868,701 bp [2] End 56,010,375 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon left ovary right ovary ganglionic eminence ventricular zone tibia body of uterus testicle right uterine tube gastric mucosa Top expressed in Rostral migratory stream genital tubercle hand ciliary body tail of embryo superior cervical ganglion retinal pigment epithelium otolith organ utricle granulocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity cysteine-type peptidase activity protein binding hydrolase activity G protein-coupled receptor activity SUMO-specific endopeptidase activity Cellular component intracellular anatomical structure nucleus plasma membrane cytoplasm Biological process proteolysis adenylate cyclase-modulating G protein-coupled receptor signaling pathway protein desumoylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57337 66315 Ensembl ENSG00000138468 ENSMUSG00000052917 UniProt Q9BQF6 Q8BUH8 RefSeq (mRNA) NM_001077203 NM_001282801 NM_001282802 NM_001282803 NM_001282804 NM_020654 NM_001003971 NM_001003972 NM_001003973 NM_025483 NM_001304503 NM_001360073 RefSeq (protein) NP_001070671 NP_001269730 NP_001269731 NP_001269732 NP_001269733 NP_065705 NP_001003972 NP_001003973 NP_001291432 NP_079759 NP_001347002 Location (UCSC) Chr 3: 101.32 – 101.51 Mb Chr 16: 55.87 – 56.01 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Sentrin-specific protease 7 is an enzyme that in humans is encoded by the SENP7 gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000138468 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000052917 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (Feb 2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi: 10.1093/dnares/7.6.347 . PMID   11214970.
6. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
7. "Entrez Gene: SENP7 SUMO1/sentrin specific peptidase 7".

Further reading

• Mikolajczyk J, Drag M, Békés M, Cao JT, Ronai Z, Salvesen GS (2007). "Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs". J. Biol. Chem. 282 (36): 26217–24. doi: 10.1074/jbc.M702444200 . PMID   17591783.
• Drag M, Mikolajczyk J, Krishnakumar IM, Huang Z, Salvesen GS (2008). "Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family". Biochem. J. 409 (2): 461–9. doi:10.1042/BJ20070940. PMID   17916063. S2CID   12234952.
• Gong L, Millas S, Maul GG, Yeh ET (2000). "Differential regulation of sentrinized proteins by a novel sentrin-specific protease". J. Biol. Chem. 275 (5): 3355–9. doi: 10.1074/jbc.275.5.3355 . PMID   10652325.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.

External links

• Overview of all the structural information available in the PDB for UniProt : Q9BQF6 (Sentrin-specific protease 7) at the PDBe-KB .